Back
Return
Biography
Spyros Zakynthinos

 

Prof. Spyros Zakynthinos
Athens University, Greece
Professor
 
Email: szakynthinos@yahoo.com
 
Qualifications
 
M.D., University of Athens, Greece
Ph.D., University of Athens, Greece

Publications (Selected)
  1. Zakynthinos S,* Vassilakopoulos T, Roussos C. The load of inspiratory muscles in patients needing mechanical ventilation. Am J Respir Crit Care 1995;152:1248-1255.    
  2. Zakynthinos S,* Vassilakopoulos T, Zakynthinos E, Roussos C. Accurate measurement of intrinsic positive end-expiratory pressure: How to detect and correct for expiratory muscle contraction. Eur Respir J 1997;10:522-529. Editorial: Ninane V. “Intrinsic” PEEP (PEEPi): role of expiratory muscles. Eur Respir J 1997;10:516-518.
  3. TzelepisG, ZakynthinosS, VassilakopoulosT, GeroulanosS, RoussosC. Inspiratory maneuver effects on peak expiratory flow: Role of lung elastic recoil and expiratory pressure Am J Respir Crit Care 1997; 156: 1399-1404.      
  4. Vassilakopoulos T, Zakynthinos S,* Roussos C. The tention - timeindex and the frequency / tidal volume ratio are the major pathophysiologicdeterminants of weaning failure and success. Am J Rerspir Crit Care 1998; 158:378-385.
  5. Routsi Ch, Bardouniotou H, Delivoria - Ioannidou V, KaziD, Roussos C, Zakynthinos S.* Pulmonary lactate release in patients with acutelung injury is not attributable to lung tissue hypoxia. Crit Care Med 1999; 27:2469-2473. Editorial: Mizock B.A. Lung injury and lactate production: A hypoxicstimulus? Crit Care Med 1999; 27: 2585-2586.
  6. Zakynthinos S,Vassilakopoulos T, Mavrommatis A, Roussos C, Tzelepis G. Effects of differentexpiratory maneuvers on inspiratory muscle force output. Am J Respir Crit CareMed 1999; 159: 892-895.
  7. Mavrommatis A, Theodoridis T, Orfanidou A,Roussos C, Christopoulou-Kokkinou V, Zakynthinos S. * Coagulation system andplatelets are fully activated in uncomplicated sepsis. Crit Care Med 2000; 28:451-157. Editorial: Kaplan K.L. Coagulation activation in sepsis. Crit Care Med2000; 28: 585-586.
  8. Zakynthinos S,* Vassilakopoulos T, Zakynthinos E, Roussos C, Tzelepis G. Correcting static intrinsic positive end-expiratory pressure for expiratory muscle contraction. Validation of a new method. Am J Respir Crit Care Med 1999; 160: 785-790. Selected for the Critical Care Journal Club web site of the ATS assembly on Critical Care, October 1999.
  9. Vassilakopoulos T, Zakynthinos S, Roussos C. Strenuous inspiratory resistive breathing produces proinflammatory cytokines and stimulates the hypothalamic - pituitary - adrenal axis in humans. Am J Physiol Regul Ιntegr Comp Physiol 1999; 277: R1013-R1019.
  10. Zakynthinos S,* Vassilakopoulos T,Zakynthinos E, Mavrommatis A, Roussos C. Contribution of expiratory muscle activity to dynamic intrinsic PEEP. Validation using the Campbell diagram. Am J Respir Crit Care Med 2000; 162: 1633-1640. Editorial: Younes M. Dynamic intrinsic PEEP (PEEPi,dyn). Is it worth saving? Am J Respir Crit Care Med 2000; 162: 1608-1609. Selected for the Critical Care Journal Club web site of the ATS assembly on Critical Care, November 2000.
  11. Vassilakopoulos T, Mastora Z, Katsaounou P, Doukas G, Klimopoulos S, Roussos C, Zakynthinos S. Contribution of pain to inspiratory muscle dysfunction after upper abdominal surgery. A randomized controlled trial. Am J Respir Crit Care Med 2000; 161: 1372-1375.
  12. Mavrommatis A, Theodoridis T, Economou M, Kotanidou A, El Ali M, Christopoulou-Kokkinou V, Zakynthinos S. Activation of the fibrinolytic system and utilization of the coagulation inhibitors in sepsis : comparison with severe sepsis and septic shock.Intensive Care Med 2001; 27: 1853-1859.
  13. Corrado A, Roussos C, Ambrosino N, Colfalonieri M, Cuvelier A, Elliot M, Gorini M, Gurkan O, Muir JF, Quareni L, Robert D, Rodenstein D, Rossi A, Schoenhofer B, Simonds AK, Strom K, Torres A, Zakynthinos S. Respiratory intensive care units: a European survey. Eur Respir J 2002; 20: 1343-1350.
  14. Zakynthinos S,*Papanikolaou S, Theodoridis T, Zakynthinos EG, Christopoulou-Kokkinou V, Katsaris G, Mavrommatis AC. Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients. Crit Care Med 2004; 32: 1004-10.
  15. Metzelopoulos S, Roussos C, Zakynthinos S. Prone position improves expiratory airway mechanics in severe chronic bronchitis.Eur Respir J 2005; 25: 259-268.
  16. Metzelopoulos S, Roussos C, Zakynthinos S. Prone position reduces lung stress and strain in severe acute respiratory distress syndrome. Eur Respir J 2005; 25: 534-544.
  17. Zakynthinos S,* Routsi C, Vassilakopoulos T, Kaltsas P, Zakynthinos E , Kazi D,Roussos C, Differential cardiovascular responses during weaning failure: effects on tissue oxygenation and lactate. Intensive Care Med 2005; 21: 1634-1642.Editorial: Richard C, Teboul J-L. Weaning failure from cardiovascular origin. Intensive Care Med 2005; 31: 1605-1607. Paper of the month at the ESICM web site.
  18. Metzelopoulos S, Roussos C, Zakynthinos S. Static pressure volume curves and body posture in acute respiratory failure.Intensive Care Med 2005; 31:1683-1692.
  19. Vassilakopoulos T, Routsi C, Bitsakou C, Sotiropoulou C, Stanopoulos J, Roussos C, Zakynthinos S.* The combination of the load/force balance and the frequency/tidal volume can predict weaning outcome. Intensive Care Med 2006; 32: 684-691.
  20. Metzelopoulos S, Sigala I, Roussos C, Zakynthinos S.* Static pressure volume curves and body posture in severe chronic bronchitis. Eur Respir J 2006; 28: 165-174.
  21. Zakynthinos S,* Katsaounou P, Karatza MH, Roussos C, Vassilakopoulos T Antioxidants increase the ventilatory response to hyperoxic hypercapnia. Am J Respir Crit Care Med 2007; 175: 62-68.
  22. Koutsourelakis I, Vagiakis E, Roussos C, Zakynthinos S.* Obstructive sleep apnoea and oral breathing in patients free of nasal obstruction. Eur Respir J 2006; 28: 1222-1228.
  23. Metzelopoulos S,Sourlas S,Koutsoukou A,Malachias S,LachanaA,Roussos C,Zakynthinos S. Acute effects of combined high frequency oscillation and tracheal gas insufflation in severe acute respiratory distress syndrome. Crit Care Med 2007; 35: 1500-1508. Editorial: Alistair N. High frequency oscillation in acute respiratory distress syndrome: Who rescues the rescuer? Crit Care Med 2007; 35: 1619-1620.
  24. Georgiadou O, Vogiatzis I, Stratakos G, Koutsoukou A, Golemati S, Aliverti A, Roussos C, Zakynthinos S. Effects of rehabilitation on chest wall volume regulation during exercise in COPD patients Eur Respir J 2007; 29: 284-291.
  25. Vogiatzis I, Stratakos G, Simoes D, Terzis G, Georgiadou O, Roussos C, Zakynthinos S. Effects of rehabilitative exercise on peripheral muscle TNF-α, IL-6, IGF-I and MyoD expression in patients with COPD. Thorax 2007; 62:950-956.
  26. Vogiatzis I, Georgiadou O, Koskolou M, Athanasopoulos D, Kostikas K, Golemati S, Wagner H, Roussos C, Wagner P, Zakynthinos S. Effects of hypoxia on diaphragmatic fatigue in highly trained athletes. J Physiol (London) 2007; 15: 299-308.
  27. Koutsourelakis I, Georgoulopoulos G, Perraki E, Vagiakis E, Roussos C, Zakynthinos S.* Randomized trial of nasal surgery for fixed nasal obstruction in obstructive sleep apnoea. Eur Respir J 2008; 31: 110-117.                
  28. Stratakos G, Porfyridis I, Papas V, Kandaraki C, Zissis C, Mariatou V, Liapikou A, Roussos C, Zakynthinos S. Exclusive diagnostic contribution of the histology specimens obtained by 19-gauge TBNA needle in suspected malignant intrathoracic lymphadenopathy. Chest. 2008; 133: 131-136.
  29. Vogiatzis I, Stratakos G , Athanasopoulos D, Georgiadou O, Golemati S, Koutsoukou A, Weisman I, Roussos C, Zakynthinos S. Chest wall volume regulation during exercise in COPD patients with GOLD stages II to IV. Eur Respir J 2008; 32: 42-52.
  30. Vogiatzis I, Zakynthinos S,* Boushel R, Athanasopoulos D, Guenette JA, Wagner HE, Roussos C, Wagner P. The contribution of intrapulmonary shunts to the alveolar to arterial oxygen difference during exercise is very small. J Physiol (London) 2008; 586: 2381-2391.
  31. Metzelopoulos S, Zakynthinos S, Tzoufi M, Katsios N, Papastylianou A, Gkizioti S, Stathopoulos A, Killintza A, Stamataki E, Roussos C. Vasopressin, epinephrine, and corticosteroids for inhospital cardiac arrest. Arch Internal Med 2009; 169: 15-24.
  32. Vogiatzis I, Athanasopoulos D, Boushel R, Guenette J, Maria Koskolou, Vasilopoulou M, Wagner H, Roussos C, Wagner P, Zakynthinos S. Contribution of respiratory muscle blood flow to exercise-induced diaphragmatic fatigue in trained cyclists.J Physiol (London) 2008; 586: 5575 - 5587.  
  33. Koutsourelakis I, Perraki E, Dimitrokalli P, Economou N, Vagiakis E, Roussos C, Zakynthinos S. Predictors of residual sleepiness in adequately treated obstructive sleep apnoea patients. Eur Respir J 2009; 34:687-693.  
  34. Vogiatzis I, Athanasopoulos D, Habazettl H, Kuebler W, Wagner H, Roussos C, Wagner P, Zakynthinos S. Intercostal muscle blood flow limitation in athletes during maximal exercise. J Physiol (London) 2009; 587:3665-3677. Editorial (Perspective): Secher N, Richardson RS. A large slice of cardiac output or humble pie for the respiratory muscles? J Physiol (London) 2009; 587: 3411.
  35. Vogiatzis I, Simoes D, Stratakos G, Kourepini E, Terzis G, Manta P, Athanasopoulos D, Roussos C, Wagner P, Zakynthinos S. Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPD. Eur Respir J. 2010; 36: 301-310.
  36. Metzelopoulos S, Malachias S, Κokkoris S, Roussos C, Zakynthinos S. Comparison of high-frequency oscillation and tracheal gas insufflation versus standard high-frequency oscillation at two levels of tracheal pressure. Intensive Care Med. 2010; 36:810-816. 
  37. Vogiatzis I, Athanasopoulos D, Habazettl H, Aliverti A, Louvaris Z, Herouvim E, Wagner H, Roussos C, Wagner P, Zakynthinos S. Intercostal muscle blood flow limitation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010; 182: 1105-1113.