Dr. Antoine Malek

Dr. Antoine Malek

University Hospital Zurich, Switzerland



1986 Ph.D., University of Zurich, Cairo

1971 B.Sc., Ain Shams University, Cairo

Publications (selected)

  1. Menezes V, Malek A and Keelan JA. Nanoparticulate drug delivery in pregnancy: placental passage and fetal exposure. Prepared for: Current Pharmaceutical Biotechnology, Special issue on Drugs and Pregnancy. Editor: Professor Zaneta Kimber-Trojnar, Bentham Science Publishers, accepted 2011.
  2. Malek A. and Mattison DR. Drugs and medicines in pregnancy: placental disposition of opioids. Prepared for: Current Pharmaceutical Biotechnology, Special issue on Drugs and Pregnancy. Editor: Professor Zaneta Kimber-Trojnar, Bentham Science Publishers, accepted 2011.
  3. Semenov O, Bersinger NB and Malek A. Human Placental Stem Cells: Biomedical Potential and Clinical Relevance. Nova Publishers, accepted 2011.
  4. Semenov O, Koestenbauer S, Riegel M, Zech N, Zimmermann R, Zisch A, Malek A.Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of 'stemness' after isolation. Am J Obstet Gynecol, 2010, 2010; 202: 193.e1-193.e13.
  5. Wick P, Malek A, Manser P, Meili D, Maeder-Althaus X, Diener L, Diener P, Zisch A, Harald F. Krug HF and von Mandach U. Barrier capacity of human placenta for nanosized materials. Environ Health Perspect, 2010; 118: 432-6.
  6. Malek A. and Mattison DR. Drug development for use during pregnancy: impact of the placenta. Expert Rev. Obstet. Gynecol, 2010; 5(4), 437–454.
  7. Malek A. In vitro studies of ferric carboxymaltose on placental permeability using the dual perfusion model of human placenta. Arzneimittelforschung/Drug Research, 2010; 60(6a): 354–361.
  8. Malek A, Leiser R. Influence of the magnesium aspartate hydrochloride administration to the maternal circuit on the aspartate concentration of the fetal circuit under in vitro perfusion of human placenta. Eur J Obstet Gynecol Reprod Biol, 2009; 142: 12-17.
  9. Heinzelmann J, Enke U, Seyfarth L, Schleussner E, Malek A, Markert UR. Development of a human model to study homing behavior of immune cells into decidua and placental villi under ex vivo conditions. Am J Reprod Immunol, 2009; 61: 19-25.
  10. Semenov OV, Malek A, Bittermann AG, Vörös J, Zisch AH. Engineered polyelectrolyte multilayer substrates for adhesion, proliferation, and differentiation of human mesenchymal stem cells.Tissue Eng Part A, 2009; 15: 2977-2990.
  11. Malek A, Obrist C, Wenzinger S, von Mandach U. The impact of cocaine and heroin on the placental transfer of methadone. Reprod Biol Endocrinol, 2009; 7: 61.
  12. Guller S, Ma Y, Malek A, Di Santo S, Schneider H. Differential release of plasminogen activator inhibitors (PAIs) during dual perfusion of human placenta: implications in preeclampsia. Placenta, 2007; 28: 278-285.
  13. Malek A, Bersinger NA, Di Santo S, Mueller MD, Sager R, Schneider H, Ghezzi F, Karousou E, Passi A, De Luca G, Raio L. C-Reactive Protein Production in Term Human Placental Tissue. Placenta, 2006; 27: 619-625.
  14. Portmann-Lanz CB, Schoeberlein A, Huber A, Sager R, Malek A, Holzgreve W, Surbek DV. Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuroregeneration. Am J Obstet Gynecol, 2006; 194: 664-673.
  15. Gupta AK, Rusterholz C, Huppertz B, Malek A, Schneider H, Holzgreve W, Hahn S. A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells. Placenta, 2005; 26: 59-66.
  16. Gupta AK, Holzgreve W, Huppertz B, Malek A, Schneider H, Hahn S. Detection of fetal DNA and RNA in placenta-derived syncytiotrophoblast microparticles generated in vitro. Clin Chem, 2004; 50: 2187-2190.
  17. Raio L, Ghezzi F, Mueller MD, McDougall J, Malek A. Evidence of fetal C-reactive protein urinary excretion in early gestation. Obstet Gynecol, 2003; 101: 1062-1063.
  18. Malek A. Ex vivo human placenta models: transport of immunoglobulin G and its subclasses. Vaccine, 2003; 21: 3362-3364.
  19. Guller S, Ma Y, Raju U, Kadner S, Thung SF, Colasacco L, Malek A, Schneider H. Release of oncofetal fibronectin from human placenta. Placenta, 2003; 24: 843-850.
  20. Di Santo S, Malek A, Sager R, Andres A-C and Schneider H. Trophoblast viability in perfused term placental tissue and explant cultures limited to 7-24 hours. Placenta, 2003; 24: 882-894.