Dr. Raymond Chuen-Chung Chang

Dr. Raymond Chuen-Chung Chang

Department of Anatomy

The University of Hong Kong, China



1997 Ph.D., University of Munich

Publications (selected)

  1. Cheung YT, Zhang NQ, Hung CHL, Lai CSW, Yu MS, So KF and Chang RCC* (2011) Temporal Relationships of autophagy and neuronal apoptosis in low molecular weight β-amyloid peptide neurotoxicity. J. Cell. Mol. Med., 15, 244-257.
  2. Ho YS, Chiu K, Hung CHL, So KF and Chang RCC (2011) Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases? In: Akhlaq A. Farooqui Ed. Phytochemicals and Human Health: Pharmacological and Molecular Aspects. Nova Publisher (Book Chapter). In press.
  3. Ho YS, So KF and Chang RCC (2011) Drug discovery from Chinese Medicine against neurodegeneration in Alzheimer’s and vascular dementia. CHINESE MEDICINE, 6: 15.
  4. Ho YS, Hung CHL, Chang RCC (2011) Green tea and neurodegeneration in Alzheimer’s disease. In: Victor R. Preedy Ed. Tea in Health and Disease Prevention Elsevier Publisher (Book Chapter). In Press.
  5. Lau BW, Ren C, Yang J, L Yan SW, Chang RCC, Pu M, So KF (2011) Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal Mongolian gerbil (Meriones unguiculatus). Cell Transplant., In press.
  6. Li SY, Yang D, Yeung CM, Yu WY, Chang RCC, So KF, Wong D, Lo ACY (2011) Lycium barbarum polysaccharides reduce neuronaldamage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. Plos One, e16380.
  7. Chiu K, Liang YX, Chang RCC, So KF (2011) Lycium barbarum L.: a neuroprotective drug for glaucoma. Ophthalmol. CHN., 20, 21-27.
  8. Chiu K, Chan TF, Wu A, Leung IYP, So KF, Chang RCC (2011) Neurodegeneration in the retina of mouse models of Alzheimer’s disease: what can we learn from the retina? AGE, In Press.
  9. Chiu K, So KF, Chang RCC (2011) Immune modulation in glaucoma - can manipulation on microglia activation help? In: Tomaš Kubena Ed. Glaucoma, Book 2; InTech Open Access Publisher (Book Chapter). In press.
  10. Ho YS, Yu MS, Yang X, So KF, Yuen WH and Chang RCC (2010) Neuroprotective effects of polysaccharides from Wolfberry antagonize homocysteine-induced toxicity in rat cortical neurons. J. Alzheimer Dis., 19, 813-827.
  11. Ho YS, So KF and Chang RCC (2010) Anti-aging herbal medicine – how and why can they be used in aging-associated neurodegenerative diseases? Ageing Res. Rev., 9, 354-362.
  12. Wuwongse S, Chang RCC and Law ACK (2010) The putative neurodegenerative links between depression and Alzheimer’s disease. Prog. Neurobiol., 91, 362-375.
  13. Chao J, Li H, Cheng KW, Yu MS, Chang RCC and Wang M (2010) Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J. Nutr. Biochem., 21, 482-489.
  14. Chiu K, Yeung SC, So KF and Chang RCC (2010) Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma. Cell. Mol. Immunol., 7, 61-68.
  15. Yu HT, Chan WWL, Chai KH, Lee CWC, Chang RCC, Yu MS, McLoughlin DM, Miller CCJ and Lau KF (2010) Transcriptional regulation of human FE65, a ligand of Alzheimer’s disease amyloid precursor protein, by Sp1. J. Cell. Biochem., 109, 782-783.
  16. Cheung YT, Lau WKW and Chang RCC (2010) What do we need to concern in using cell line for neurotoxicology research, differentiation or disturbance of intracellular signaling? NeuroToxicology, 31, 164-166.
  17. Chao J, Lau KW, Huie MJ, Ho YS, Yu MS, Lai CSW, Wang M, Yuen WH, Lam WH, Chan TH and Chang RCC (2010) A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine. Neurosci. Letters, 469, 360-364.
  18. Chiu K, Zhou Y, Yeung SC, Lok CKM, Chan OOC, Chang RCC, So KF and Chiu JF (2010) Up-regulation of crystallins is involved in neuroprotective effects of Wolfberry on survival of retinal ganglion cells in rat ocular hypertension model. J. Cell. Biochem., 110, 311-320.
  19. Hung CHL, Ho YS and Chang RCC (2010) Modulations of mitochondrial calcium as a pharmacological target for Alzheimer’s disease. Ageing Res. Rev., 9, 447-456.
  20. Peng X, Ma J, Chao J, Sun Z, Chang RCC, Tse I, Li ETS, Chen F and Wang M (2010) Beneficial effects of cinnamon proanthocyanidins on the formation of specific glycation endproducts and methylglyoxal-induced impairment on glucose consumption. J. Arg. Food Chem., 58, 6692-6696.
  21. Zheng ZP, Ma J, Cheng KW, Chao J, Zhu Q, Chang RCC, Zhao M, Lin ZX, Wang M. (2010) Sulfur-containing constituents and one 1H-pyrrole-2-carboxylic acid derivative from pineapple [Ananas comosus (L.) Merr.] fruit. Phytochemistry, 71, 2046-2051.
  22. Chang RCC, Ho YS, Yu MS and So KF (2010) Medicinal and nutraceutical uses of wolfberry in preventing neurodegeneration in Alzheimer’s disease. In: Charles Ramassamy and Stéphane Bastianetto Eds. Recent Advances on Nutrition and Alzheimer’s disease. (Book Chapter). pp. 169-185.
  23. Chang RCC, Chao J, Yu MS and Wang M (2010) Neuroprotective effects of oxyresveratrol from fruit against neurodegeneration in Alzheimer’s disease. In: Charles Ramassamy and Stéphane Bastianetto Eds. Recent Advances on Nutrition and Alzheimer’s disease. (Book Chapter). pp. 155-168.
  24. So KF and Chang RCC (2010) Ginseng, Wolfberry, Bilberry in “Section 8: Non-pharmaceutical Medications and Approaches”. In: R.N. Weinreb & J. Liebmann Ed. Medical Treatment of Glaucoma: World Glaucoma Association Consensus Series 7. Kugler Publication (Book Chapter). pp. 237-242.