Dr. Didier Merlin

Emory University, USA



1994 Ph.D., Cell Biology, University Paris VII, France

1989 M.S., Cell Biology, University Paris VII, France

Publications (Selected)

  1. S.L. Lebeis, K.R. Powell, D. Merlin, M.A. Sherman, D. Kalman. Interleukin-1 receptor signaling protects mice from lethal intestinal damage caused by the attaching and effacing pathogen Citrobacter rodentium. Infect Immun. 2009 Feb;77(2):604-14.
  2. P. Garg, M. Vijay-Kumar, L. Wang, A.T. Gewirtz, D. Merlin, S.V. Sitaraman. Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. Am J Physiol Gastrointest Liver Physiol. 2009
  3. A.L. Theiss, M. Vijay-Kumar, T.S. Obertone, D.P. Jones, J.M. Hansen, A.T. Gewirtz, D. Merlin, S.V. Sitaraman. Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice. Gastroenterology. 2009 Mar 25. [Epub ahead of print]
  4. Y. Yan, G. Dalmasso, H.T. Nguyen, T.S. Obertone, S.V. Sitaraman, D. Merlin. Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function. PLoS One. 2009;4(4):e5049.
  5. B.P. Chandrasekharan, V.L. Kolachala, G. Dalmasso, D. Merlin, K. Ravid, S.V. Sitaraman, S. Srinivasan. Adenosine 2B receptors (A2BAR) on enteric neurons regulate murine distal colonic motility. FASEB J. 2009; 23(8):2727-34.
  6. Y. Yutao, V. Kolachala, G. Dalmasso, H. Nguyen, S.V. Sitaraman, D. Merlin. Cytokine profile in DSS induced experimental colitis. PLoS. One. 2009;4(6):e6073.
  7. H.T.T. Nguyen, G. Dalmasso, K. R. Powell, Y. Yan, S. Bhatt, D. Kalman, S. Sitaraman, D. Merlin. Pathogenic bacteria induce colonic PepT1 expression: an implication in host defense response. Gastroenterology. 2009; 137(4):1435-47.
  8. S. Bhatt, A.N. Edwards, H.T. Nguyen, D. Merlin, T. Romeo, D. Kalman D. The RNA binding protein CsrA is a pleiotropic regulator of the locus of enterocyte effacement pathogenicity island of enteropathogenic Escherichia coli. Infect Immun. 2009; 77(9):3552-68.
  9. A.L. Theiss, A.K. Jenkins, N.I. Okoro, J.M. Klapproth, D. Merlin, S.V. Sitaraman. Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression. Mol Biol Cell. 2009; 20(20):4412-23.
  10. H.T. Nguyen, G. Dalmasso, Y. Yan, H. Laroui, S. Dahan, L. Mayer, S.V. Sitaraman, D. Merlin. MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation. J Biol Chem. 2010; 285:1479-89.
  11. P. Garg, D. Sarma, S. Jeppsson, NR. Patel, AT. Gewirtz, D. Merlin, S.V. Sitaraman. Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. Cancer Res. 2010; 70(2):792-801.
  12. H. Laroui, G. Dalmasso, H. Nguyen, Y. Yan, SV. Sitaraman, D. Merlin. Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model. Gastroenterology. 2010; 138(3):843-53.
  13. Kolachala VL, Wang L, Obertone TS, Prasad M, Yan Y, Dalmasso G, Gewirtz A, Merlin D, Sitaraman SV. Adenosine 2B receptor expression is post-transcriptionally regulated by microRNA. J Biol Chem. 2010 Apr 13. [Epub ahead of print]
  14. G. Dalmasso, H. Nguyen, L. Charrier-Hisamuddin, Y. Yan, H. Laroui, S. Sitaraman, D. Merlin. PepT1 mediates transport of the bacterial peptidoglycan pro-inflammatory tripeptide L-Ala-γ-D-Glu-meso-DAP in intestinal epithelial cells. 2010. Am. J. Physiol, Gastrointest Liver Physiol. In Press.