Dr. Alexander Y. Tsygankov

Dr. Alexander Y. Tsygankov

Temple University, USA





1988  Ph.D., Bach Institute of Biochemistry, Russia

1982  M.Sc., Moscow University, Russia

1980  B.Sc., Moscow University, Russia


Publications (Selected)

  1. Tsygankov, A.Y., Spana, C., Rowley, B.R., Penhallow, R.C., Burkhardt, A.L., Bolen, J.B. Activation-depend­ent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes. J. Biol. Chem. 269:7792-7800, 1994. PMID: 8126006
  2. Feshchenko, E.A., Langdon, W.Y., Tsygankov, A.Y. Fyn, Yes and Syk phosphorylation sites in c‑Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J. Biol. Chem. 273:8323-8331, 1998. PMID: 9525940
  3. Feshchenko, E.A., Shore, S.K., Tsygankov, A.Y. Tyrosine phosphorylation of c‑Cbl facilitates adhesion and spreading of NIH 3T3 cells while suppressing their transformation by v‑Abl. Oncogene 18:3703-3715, 1999. PMID: 10391678
  4. HIV Henderson, E.E., Tsygankov, A.Y., Merlo, J.J., Romano, G., Guan, M. Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express Herpesvirus saimiri proteins StpC and/or Tip. Virology. 264:125-33,1999. PMID: 10544137
  5. Levkowitz, G., Waterman, H., Ettenberg, S.A., Tsygankov, A.Y., Alroy, I., Lavi, S., Iwai, K., Reiss, Y., Ciechanover, A., Lipkowitz, S., Yarden, Y. Ubiquitin conjugation to EGF-receptors is mediated by Cbl proto-oncogenic proteins and tyrosine phosphorylation. Molecular Cell 4:1029-1040, 1999. PMID: 10635327
  6. Teckchandani, A.M., Feshchenko, E.A., Tsygankov, A.Y. c‑Cbl facilitates fibronectin matrix production by v‑Abl-transformed NIH 3T3 cells via activation of small GTPases. Oncogene 20:1739-1755, 2001. PMID: 11313921
  7. HIV Hasham, M.G., Tsygankov, A.Y. Tip, an Lck-interacting protein of Herpesvirus saimiri, causes Fas- and Lck-dependent apoptosis of T lymphocytes. Virology. 320:313-329, 2004. PMID: 1501655
  8. Feshchenko, E.A., Swaminathan, G., Teckchandani, A.M., Agrawal, R., Smirnova, E.V., Zhang, X., Annan, R.S., Carr, S.A., Tsygankov, A.Y. TULA: An SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. Oncogene, 23:4690-4706, 2004. PMID: 15107835
  9. Sorokina, E.M., Merlo, J.J. Jr., Tsygankov, A.Y. Molecular mechanisms of the effect of Herpesvirus saimiri protein StpC on the signaling pathway leading to NF-kappaB activation. J. Biol. Chem., 279:13469-77, 2004. PMID: 14724292
  10. HIV Raymond, A.D., Hasham, M., Tsygankov, A.Y., Henderson, E.E. Herpesvirus saimiri-encoded proteins Tip and StpC modulate human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes independently of viral tropism. Virology. 324:60-6, 2004. PMID: 15183053
  11. Dangelmaier, C.A., Quinter, P.G., Jin, J., Tsygankov, A.Y., Kunapuli, S.P., Daniel, J.L. Rapid ubiquitination of Syk following GPVI activation in platelets. Blood, 105:3918-3924, 2005. PMID: 15701717
  12. Teckchandani, A.M., Panetti, T.S., Tsygankov, A.Y. c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1. Exp Cell Res 307, 247-258, 2005.PMID: 15922744
  13. Swaminathan, G., Tsygankov, A.Y. The Cbl family proteins: ring leaders in regulation of cell signaling. J Cell Physiol 209, 21-43, 2006.PMID: 16741904
  14. HIV Raymond, A.D., Hasham, M., Tsygankov, A.Y., Henderson, E.E. H. saimiri tyrosine-kinase interacting protein inhibits Tat function: a prototypic strategy for restricting HIV-1-induced cytopathic effects in immune cells. Virology. 352:253-67, 2006. PMID: 16780912
  15. HIV Turner, L.S., Tsygankov, A.Y., Henderson, E.E. StpC-based gene therapy targeting latent reservoirs of HIV-1. Antiviral Res. 72:233-41, 2006. PMID: 16891001
  16. Swaminathan, G., Feshchenko, E.A. Tsygankov, A.Y. c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl. Oncogene, 26:4095-105, 2007. PMID: 17237826
  17. Collingwood, T.S., Smirnova, E.V., Bogush, M., Carpino, N., Annan, R.S., Tsygankov, A.Y. TULA affects cell death through a functional interaction with AIF, a key factor of caspase-independent apoptosis. J. Biol. Chem. 282:30920-30928, 2007. PMID: 17709377
  18. HIV Raymond, A.D., Hasham, M., Tsygankov, A.Y., Henderson, E.E. Herpesvirus saimiri terminal membrane proteins modulate HIV-1 replication by altering Nef and Tat functions. Curr HIV Res. 5:79-86, 2007. PMID: 17266559
  19. HIV Smirnova, E.V., Collingwood, T.S., Tsygankova, O.M., Bogush, M., Meinkoth, J., Bisbal, C., Annan, R.S., Tsygankov, A.Y. The SH3- and UBA-containing protein TULA binds to ABCE-1, a host factor of HIV-1 assembly, and inhibits HIV-1 biogenesis. Virology, 372:10-23, 2008. PMID: 18006034
  20. Agrawal, R., Carpino, N., Tsygankov, A. TULA proteins regulate activity of the protein tyrosine kinase Syk. J. Cell. Biochem. 104:953-964, 2008. PMID: 18189269
  21. Lee, H., Gaughan, J.P., Tsygankov, A.Y. c-Cbl facilitates cytoskeletal effects in v-Abl transformed fibroblast through Rac1-and Rap1-mediated signaling. Int. J. Biochem. Cell Biol. 40:1930-1943, 2008. PMID: 18403249
  22. Tsygankov, A.Y. Multidomain STS/TULA proteins are novel cellular regulators. IUBMB Life. 60:224-231, 2008. PMID: 1834418
  23. Tsygankov, A.Y. TULA-family proteins: an odd couple. Cell Mol Life Sci. 66:2949-2952, 2009. PMID: 19585081.
  24. HIV Tsygankov, A.Y Current developments in anti-HIV/AIDS gene therapy. Curr Opin Investig Drugs. 10:137-49, 2009.PMID: 19197791
  25. Adapala, N.S., Barbe, M.F., Langdon, W.Y., Tsygankov, A.Y., Sanjay, A. Cbl-phosphatidylinositol 3 kinase interaction differentially regulates macrophage colony-stimulating factor-mediated osteoclast survival and cytoskeletal reorganization. Ann N Y Acad Sci. 1192:376-384, 2010. PMID: 20392263
  26. Daniel, J.L., Dangelmaier, C.A., Mada, S., Buitrago, L., Jin, J., Langdon, W.Y., Tsygankov, A.Y., Kunapuli, S.P., Sanjay, A. Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation. J Biol Chem. 285:17282-17291, 2010. PMID: 20400514
  27. Thomas, D.H., Getz,T.M., Newman, T.N., Dangelmaier,C.A., Carpino, N., Kunapuli, S.P., Tsygankov,A.Y.*, Daniel, J.L.*A Novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood, 116:2570-8, 2010. PMID: 20585042
  28. Chen, X., Ren, L., Kim, S., Carpino, N., Daniel, J.L., Kunapuli, S.P., Tsygankov, A.Y.*, Pei, D.* Determination of the substrate specificity of protein tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem. 285:31268-7, 2010. PMID: 20670933
  29. Adapala, N.S., Barbe, M.F., Langdon, W.Y., Nakamura, M.C., Tsygankov, A.Y., Sanjay, A. The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival. J Biol Chem. 285:36745-58, 2010. PMID: 20851882
  30. Lee, H, Tsygankov, A.Y. c-Cbl regulates glioma invasion through matrix metalloproteinase 2. J Cell Biochem. 111:1169-78, 2010. PMID: 20717917