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Biography
Fausto Titti

Prof. Fausto Titti

National AIDS Center, Italy

 

Email: fausto.titti@iss.it

 

Qualifications

1977  Ph.D., University of Camerino, Italy

 

Publications (Selected)

  1. Ferrantelli F, Maggiorella MT, Schiavoni I, Sernicola L, Olivieri E, Farcomeni S, Pavone-Cossut MR, Moretti S, Belli R, Collacchi B, Srivastava IK, Titti F, Cafaro A, Barnett SW, Ensoli B. A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study. Vaccine. 2011 Apr 5;29(16):2918-32. Epub 2011 Feb 21.
  2. Cafaro A, Bellino S, Titti F, Maggiorella MT, Sernicola L, Wiseman RW, Venzon D, Karl JA, O'Connor D, Monini P, Robert-Guroff M, Ensoli B. Impact of viral dose and major histocompatibility complex class IB haplotype on viral outcome in mauritian cynomolgus monkeys vaccinated with Tat upon challenge with simian/human immunodeficiency virus SHIV89.6P. J Virol. 2010 Sep;84(17):8953-8. Epub 2010 Jun 16.
  3. Ham C, Srinivasan P, Thorstensson R, Verschoor E, Fagrouche Z, Sernicola L, Ramos A, Titti F, Almond N, Berry N. International multicenter study to assess a panel of reference materials for quantification of simian immunodeficiency virus RNA in plasma. J Clin Microbiol. 2010 Jul;48(7):2582-5. Epub 2010 Apr 28.
  4. Lewis MG, Norelli S, Collins M, Barreca ML, Iraci N, Chirullo B, Yalley-Ogunro J, Greenhouse J, Titti F, Garaci E, Savarino A. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology. 2010 Mar 16;7:21
  5. Ridolfi B, Catone S, Sgarbanti M, Sernicola L, Battistini A, Parolin C, Titti F, Borsetti A. Generation of a human immunodeficiency virus type 1 chronicallyn infected monkey B cell line expressing low levels of endogenous TRIM5alpha. J Cell Physiol. 2009 Dec;221(3):760-5.
  6. Mee ET, Berry N, Ham C, Sauermann U, Maggiorella MT, Martinon F, Verschoor EJ, Heeney JL, Le Grand R, Titti F, Almond N, Rose NJ. Mhc haplotype H6 is associated with sustained control of SIVmac251 infection in Mauritian cynomolgus macaques. Immunogenetics. 2009 May;61(5):327-39. Epub 2009 Apr 1.
  7. Borsetti A, Baroncelli S, Maggiorella MT, Moretti S, Fanales-Belasio E, Sernicola L, Tripiciano A, Macchia I, Michelini Z, Belli R, Farcomeni S, Pavone-Cossut MR, Negri D, Caputo A, Bellino S, Butto S, Titti F, Cafaro A, Ensoli B. Containment of infection in tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6P(cy243). Viral Immunol. 2009 Apr;22(2):117-24.
  8. Fanales-Belasio E, Moretti S, Fiorelli V, Tripiciano A, Pavone Cossut MR, Scoglio A, Collacchi B, Nappi F, Macchia I, Bellino S, Francavilla V, Caputo A, Barillari G, Magnani M, Laguardia ME, Cafaro A, Titti F, Monini P, Ensoli F, Ensoli B. HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection. J Immunol. 2009 Mar 1;182(5):2888-97.
  9. Cafaro A, Macchia I, Maggiorella MT, Titti F, Ensoli B. Innovative approaches to develop prophylactic and therapeutic vaccines against HIV/AIDS. Adv Exp Med Biol. 2009;655:189-242.
  10. Caputo A, Gavioli R, Bellino S, Longo O, Tripiciano A, Francavilla V, Sgadari C, Paniccia G, Titti F, Cafaro A, Ferrantelli F, Monini P, Ensoli F, Ensoli B. HIV-1 Tat-based vaccines: an overview and perspectives in the field of HIV/AIDS vaccine development. Int Rev Immunol. 2009;28(5):285-334. Review.
  11. Florese RH, Wiseman RW, Venzon D, Karl JA, Demberg T, Larsen K, Flanary L, Kalyanaraman VS, Pal R, Titti F, Patterson LJ, Heath MJ, O'Connor DH, Cafaro A, Ensoli B, Robert-Guroff M. Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV(89.6P) infection. Vaccine. 2008 Jun 19;26(26):3312-21. Epub 2008 Apr 30
  12. Ridolfi B, Genovese D, Argentini C, Maggiorella MT, Sernicola L, Buttò S, Titti F, Borsetti A, Ensoli B. Tat protein vaccination of cynomolgus macaques influences SHIV-89.6P cy243 epitope variability. Virus Genes. 2008 Feb;36(1):105-15. Epub 2007 Nov 30.
  13. Borsetti A, Baroncelli S, Maggiorella MT, Bellino S, Moretti S, Sernicola L, Belli R, Ridolfi B, Farcomeni S, Negri DR, Cafaro A, Ensoli B, Titti F. Viral outcome of simian-human immunodeficiency virus SHIV-89.6P adapted to cynomolgus monkeys. Arch Virol. 2008;153(3):463-72. Epub 2007 Dec 15.
  14. Maggiorella MT, Sernicola L, Crostarosa F, Belli R, Pavone-Cossut MR, Macchia I, Farcomeni S, Tenner-Racz K, Racz P, Ensoli B, Titti F. Multiprotein genetic vaccine in the SIV-Macaca animal model: a promising approach to generate sterilizing immunity to HIV infection. J Med Primatol. 2007 Aug;36(4-5):180-94.
  15. Bona R, Macchia I, Baroncelli S, Negri DR, Leone P, Pavone-Cossut MR, Catone S, Buffa V, Ciccozzi M, Heeney J, Fagrouch Z, Titti F, Cara A. T cell receptor excision circles (TRECs) analysis during acute intrarectal infection of cynomolgus monkeys with pathogenic chimeric simian human immunodeficiency virus. Virus Res. 2007 Jun;126(1-2):86-95. Epub 2007 Mar 2.
  16. Titti F, Cafaro A, Ferrantelli F, Tripiciano A, Moretti S, Caputo A, Gavioli R, Ensoli F, Robert-Guroff M, Barnett S, Ensoli B. Problems and emerging approaches in HIV/AIDS vaccine development. Expert Opin Emerg Drugs. 2007 Mar;12(1):23-48. Review.
  17. Ensoli B, Fiorelli V, Ensoli F, Cafaro A, Titti F, Buttò S, Monini P, Magnani M, Caputo A, Garaci E. Candidate HIV-1 Tat vaccine development: from basic science to clinical trials. AIDS. 2006 Nov 28;20(18):2245-61. Review.
  18. Negri DR, Borghi M, Baroncelli S, Macchia I, Buffa V, Sernicola L, Leone P, Titti F, Cara A. Identification of a cytotoxic T-lymphocyte (CTL) epitope recognized by Gag-specific CTLs in cynomolgus monkeys infected with simian/human immunodeficiency virus. J Gen Virol. 2006 Nov;87(Pt 11):3385-92.
  19. Goletti D, Macchia I, Leone P, Pace M, Sernicola L, Pavone-Cossut MR, Maggiorella MT, Cafaro A, Ensoli B, Titti F. Innate anti-viral immunity is associated with the protection elicited by the simian immunodeficiency virus (SIV) live attenuated virus vaccine in cynomolgus monkeys. Med Sci Monit. 2006 Oct;12(10):BR330-40. Epub 2006 Sep 25.
  20. Masella R, Varì R, D'Archivio M, Santangelo C, Scazzocchio B, Maggiorella MT, Sernicola L, Titti F, Sanchez M, Di Mario U, Leto G, Giovannini C. Oxidised LDL modulate adipogenesis in 3T3-L1 preadipocytes by affecting the balance between cell proliferation and differentiation. FEBS Lett. 2006 May 1;580(10):2421-9.Epub 2006 Mar 30.
  21. Ensoli B, Cafaro A, Caputo A, Fiorelli V, Ensoli F, Gavioli R, Ferrantelli F, Cara A, Titti F, Magnani M. Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant DeltaV2 Env.Microbes Infect. 2005 Nov;7(14):1392-9. Epub 2005 Sep 15. PubMed PMID: 16243561.
  22. Michelini Z, Negri DR, Baroncelli S, Catone S, Comini A, Maggiorella MT, Sernicola L, Crostarosa F, Belli R, Mancini MG, Farcomeni S, Fagrouch Z, Ciccozzi M, Rovetto C, Liljestrom P, Norley S, Heeney J, Titti F. T-cell-mediated protective efficacy of a systemic vaccine approach in cynomolgus monkeys after SIV mucosal challenge. J Med Primatol. 2004 Oct;33(5-6):251-61.
  23. Ferrero E, Orciani M, Vacca P, Ortolan E, Crovella S, Titti F, Saccucci F, Malavasi F. Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque. BMC Immunol. 2004 Sep 21;5:21.
  24. Maggiorella MT, Baroncelli S, Michelini Z, Fanales-Belasio E, Moretti S,Sernicola L, Cara A, Negri DR, Buttò S, Fiorelli V, Tripiciano A, Scoglio A, Caputo A, Borsetti A, Ridolfi B, Bona R, ten Haaft P, Macchia I, Leone P, Pavone-Cossut MR, Nappi F, Ciccozzi M, Heeney J, Titti F, Cafaro A, Ensoli B.Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys. Vaccine. 2004 Sep 3;22(25-26):3258-69.
  25. Ridolfi B, Titti F, Fulgenzi D, Maggiorella MT, Tinari A, Superti F, Parolin C, Ensoli B, Borsetti A. Infection of a simian B cell line by human and simian immunodeficiency viruses. AIDS Res Hum Retroviruses. 2004 Jul;20(7):723-32.
  26. Cara A, Maggiorella MT, Bona R, Sernicola L, Baroncelli S, Negri DR, Leone P, Fagrouch Z, Heeney J, Titti F, Cafaro A, Ensoli B. Circular viral DNA detection and junction sequence analysis from PBMC of SHIV-infected cynomolgus monkeys with undetectable virus plasma RNA. Virology. 2004 Jul 1;324(2):531-9.
  27. Leuchte N, Berry N, Köhler B, Almond N, LeGrand R, Thorstensson R, Titti F, Sauermann U. MhcDRB-sequences from cynomolgus macaques (Macaca fascicularis) of different origin. Tissue Antigens. 2004 Jun;63(6):529-37.
  28. Negri DR, Baroncelli S, Catone S, Comini A, Michelini Z, Maggiorella MT, Sernicola L, Crostarosa F, Belli R, Mancini MG, Farcomeni S, Fagrouch Z, Ciccozzi M, Boros S, Liljestrom P, Norley S, Heeney J, Titti F. Protective efficacy of a multicomponent vector vaccine in cynomolgus monkeys after intrarectal simian immunodeficiency virus challenge. J Gen Virol. 2004 May;85(Pt 5):1191-201.
  29. Di Fabio S, Corrias F, Monardo F, Titti F. Flow cytometry analysis of immune cell populations isolated from cervicovaginal secretions of cynomolgus monkeys. J Immunol Methods. 2004 Jan;284(1-2):7-14.