Dr. Yonghe Li
Southern Research Institute, USA
1998 Ph.D., Biochemistry, James Cook University of North Queensland, Australia
1988 M.Sc., Radiobiology, School of Graduate Studies, Shanghai Medical University, China
1985 B.Sc., Pharmacology, School of Pharmacy, Shanghai Medical University, China
Tinsley HN, Gary BD, Thaiparambil J, Li N,
Lu W, Li Y, Maxuitenko YY, Keeton AB, and Piazza GA. Colon tumor cell growth
inhibitory activity of sulindac sulfide and other NSAIDs is associated with
PDE5 inhibition. Cancer Prev Res, 3:1303-1313, 2010.
Li Y, Lu W, King TD, Liu C-C, Bijur
GN, and Bu G. Opposing roles of Dkk1 in LRP6 stabilization and Wnt signaling:
implication for Wnt ligand-induced LRP6 down-regulation. PLoS ONE, 49:4635-43,
Lu W, Liu C-C, Thottassery JV, Bu G, Li Y.
Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks
Wnt/β-catenin signaling in cancer cells. Biochemistry, 49:4635-4643,
Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt
signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic
mice: implication for breast cancer tumorigenesis. Oncogene, 29:539-549, 2010.
Piazza GA, Keeton AB, Tinsley HN, Gary BD,
Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath
JV, Maxuitenko YY, and Reynolds RC. A novel sulindac derivative that does not
inhibit cyclooxygenases but potently inhibits colon tumor cell growth and
induces apoptosis with antitumor activity. Cancer Prev Res, 2:572-580, 2009.
Lu W, Tinsley HN, Keeton A, Qu Z, Piazza
GA, and Li Y. Suppression of Wnt/b-catenin signaling inhibits prostate cancer
cell proliferation. Eur J Pharmacol, 602:8-14, 2009.
Song H, Li Y, Lee J, Schwartz AL, and Bu
G. Low-density lipoprotein receptor-related protein 1 promotes cancer cell
migration and invasion by inducing the expression of matrix metalloproteinase 2
and 9. Cancer Res, 69:879-886, 2009.
Bu G, Lu W, Liu C-C, Selander K, Yoneda T,
Hall C, Keller ET, and Li Y. Breast cancer-derived Dickkopf1 inhibits
osteoblast differentiation and osteoprotegerin expression: implication for
breast cancer osteolytic bone metastases. Int J Cancer, 123:1034-1042, 2008.
Lu W, Kim KA, Liu J, Abo A, Feng X, Cao X,
and Li Y. R-spondin1 synergizes with Wnt3A in inducing osteoblast
differentiation and osteoprotegerin expression. FEBS Lett, 582:643-650, 2008.
(This article was also collected in FEBS Letters Signalling Virtual Special
Knisely JM, Li Y, Griffith JM, Geuze HJ,
Schwartz AL, and Bu G. Slow endocytosis of the LDL receptor-related protein 1B:
Implications for a novel cytoplasmic tail conformation. Exp Cell Res,