Dr. Yonghe Li

Southern Research Institute, USA



1998    Ph.D., Biochemistry, James Cook University of North Queensland, Australia

1988    M.Sc., Radiobiology, School of Graduate Studies, Shanghai Medical University, China

1985    B.Sc., Pharmacology, School of Pharmacy, Shanghai Medical University, China

Publications (Selected)

  1. Tinsley HN, Gary BD, Thaiparambil J, Li N, Lu W, Li Y, Maxuitenko YY, Keeton AB, and Piazza GA. Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDs is associated with PDE5 inhibition. Cancer Prev Res, 3:1303-1313, 2010.
  2. Li Y, Lu W, King TD, Liu C-C, Bijur GN, and Bu G. Opposing roles of Dkk1 in LRP6 stabilization and Wnt signaling: implication for Wnt ligand-induced LRP6 down-regulation. PLoS ONE, 49:4635-43, 2010.
  3. Lu W, Liu C-C, Thottassery JV, Bu G, Li Y. Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/β-catenin signaling in cancer cells. Biochemistry, 49:4635-4643, 2010.
  4. Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene, 29:539-549, 2010.
  5. Piazza GA, Keeton AB, Tinsley HN, Gary BD, Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath JV, Maxuitenko YY, and Reynolds RC. A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. Cancer Prev Res, 2:572-580, 2009.
  6. Lu W, Tinsley HN, Keeton A, Qu Z, Piazza GA, and Li Y. Suppression of Wnt/b-catenin signaling inhibits prostate cancer cell proliferation. Eur J Pharmacol, 602:8-14, 2009.
  7. Song H, Li Y, Lee J, Schwartz AL, and Bu G. Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinase 2 and 9. Cancer Res, 69:879-886, 2009.
  8. Bu G, Lu W, Liu C-C, Selander K, Yoneda T, Hall C, Keller ET, and Li Y. Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer, 123:1034-1042, 2008.
  9. Lu W, Kim KA, Liu J, Abo A, Feng X, Cao X, and Li Y. R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett, 582:643-650, 2008. (This article was also collected in FEBS Letters Signalling Virtual Special Issue)
  10. Knisely JM, Li Y, Griffith JM, Geuze HJ, Schwartz AL, and Bu G. Slow endocytosis of the LDL receptor-related protein 1B: Implications for a novel cytoplasmic tail conformation. Exp Cell Res, 313:3298-3307, 2007.