Dr. Yigang Wang

Dr. Yigang Wang

Department of Pathology and Laboratory Medicine

Universityof Cincinnati, USA


1997 Ph.D., Tokyo Medical and Dental University, Japan

1983 M.D., Qinghai Medical College, China

Publications (Selected)

  1. Fryer RM, Hsu AK, Wang Y, Henry M, Eells J, Gross GJ. PKC- inhibition does not block preconditioning-induced protection in mitochondrial ATP synthesis and infarct size reduction in rats. Basic Res Cardiol. 2002;97:47-54.
  2. Wang Y, Wang XH, Sunamori M. Effect of histidine in the nondepolarizing cardioplegic solution on myocardial function and biochemistry. Chinese Journal of Pathophysiology. 2002;18(13):1690-1691.
  3. Wang Y and Ashraf M. Effect of ischemic preconditioning on Na+/H+ exchanger isoform-1 knockout mice. Chinese Journal of Pathophysiology. 2002;18(13):1655-1656.
  4. Kudo M, Wang Y, Xu M, Ayub A, Ashraf M. Adenosine A1 receptor mediates late preconditioning via activation of PKC-d signaling pathway. Am J Physiol Heart Circ Physiol 2002;283:H296-H301.
  5. Wang Y, Meyer W. J, Shull E G, Ashraf M. Mice With a Null Mutation in the NHE1 Na+/H+ Exchanger are Resistant to Cardiac Ischemia-Reperfusion Injury. Circ Res. 2003;93:776-782.
  6. Wang Y, Ahmad N, Kudo M, Ashraf M. Contribution of Akt and Endothelial Nitric Oxide Synthase to Diazoxide-Induced Late Preconditioning. Am J Physiol Heart Circ Physiol. 2004;287(3):H1125-31.
  7. Wang Y, Ahmad N, Wani MA, Ashraf M. Hepatocyte Growth Factor Prevents Ventricular Remodeling and Dysfunction in Mice via Akt Pathway and Angiogenesis. J Mole Cell Cardial. J Mol Cell Cardiol. 2004;37(5):1041-52.
  8. Wang Y, Haider HK, Ahmad N, Ashraf M. KATP openers and mechanisms by which these agents produce acute and delayed cardioprotection. Vascul Pharmacol. 2005;42(5-6):253-64.
  9. Wang Y, Haider HK, Ahmad N, Xu, M, Ge R, Ashraf M. Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair, JMCC. 2006;40:736-745.
  10. Wang Y, Haider HKH, Ahmad N, Zhang D, Ashraf M. Evidence for Ischemia Induced Host Derived Bone Marrow Cell Mobilization into Cardiac Allografts. J Mol Cell Cardiol. 2006;41(3):478-487.
  11. Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circ Res. 2006;99:1233-42.
  12. Wang Y, Ahmad N, Wang B, Ashraf M. Chronic preconditioning: a novel approach for cardiac protection. Am J Physiol Heart Circ Physiol. 2007;292:H2300-H2305.
  13. Pasha Z, Wang Y, Sheikh R, Zhang D, Zhao T, Ashraf M. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res. 2007. In press. Available online.
  14. Zhang D, Fan GC, Zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M, Wang Y*. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol. JMCC. 2008;44(2):281-92.
  15. Zhao T, Zhang D, Millard RW, Ashraf M, Wang Y. Stem cell homing and angiomyogenesis in transplanted hearts are enhanced by combined intramyocardial SDF-1a delivery and endogenous cytokine signaling. AJP. 2009;296(4):H976-86. PMID: 19181961
  16. Millard R, Wang Y. Milieu Inte´rieur: The search for myocardial arteriogenic signals. Journal of the American College of Cardiology (J Am Coll Cardiol). 2009;53(23):2148-9. PMID: 19497440
  17. Ahmad N, Wang Y, Ali AK, Ashraf M. Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injury. Am J Physiol Heart Circ Physiol. 2009; 297:H387-91. PMID: 19429825
  18. Jagatheesan G, Rajan S, Schulz EM, Ahmed RP, Petrashevskaya NN, Schwartz A, Boivin GP, Arteaga GM, Wang T, Wang Y, Ashraf M, Liggett SB, Lorenz JN, Solaro RJ, Wieczorek DF. An internal domain of {beta}-tropomyosin increases myofilament calcium sensitivity. Am J Physiol Heart Circ Physiol. 2009;297:H181-90. PMID: 19429821
  19. Wang X, Zingarelli B, Connor MO, Zhang P, Adeyemo A, Kranias1 EG, Wang Y, Fan GC. Overexpression of Hsp20 Prevents Endotoxin-Induced Myocardial Dysfunction and Apoptosis via Inhibition of NF-κB Activation. JMCC. 2009;47(3):382-90. PMID: 19501592
  20. Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y*, Fan GC. Hsp20-Engineered Mesenchymal Stem Cells Are Resistant to Oxidative Stress via Enhanced Activation of Akt and Increased Secretion of Growth Factors. Stem Cells. 2009 ;27(12):3021-3031. PMID: 19816949. (Co-correspondence)
  21. Huang W, Zhang D, Millard  R, Wang T, Zhao T, Fan GC, Ashraf A, Xu M, Ashraf M, Wang Y.  Gene manipulated peritoneal cell patch repairs infarcted myocardium. JMCC. 2010;48(4):702-12. PMID: 19913551.
  22. Wang Y, Zhang D, Ashraf M, Zhao T, Huang W, Ashraf A, Ambikaipakan Balasubramaniam A. Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction. AJP. 2010;298(1):H275-86. PMID: 19897711.
  23. Zhang D, Huang W, Dai B, Zhao T, Ashraf A, Millard RW, Ashraf M, Wang Y. Genetic manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts. Am J Physiol Heart Circ Physiol. 2010 299(5):H1339-47.  PMID: 20802132.
  24. Huang W, Wang T, Zhang D, Zhao T, Dai B, Ashraf A, Wang X, Xu M, Millard RW, Fan GC, Ashraf M, Yu XY, Wang Y. Mesenchymal Stem Cells Overexpressing CXCR4 Attenuate Remodeling of Post-myocardial Infarction by Releasing Matrix Metalloproteinase-9. Stem Cell and Development. Stem Cells Dev. 2011 Jun 14. [Epub ahead of print] PMID:21671800.
  25. Dai B, Huang W, Xu M, Millard RW, Gao MH, Hammond HK, Menick DR, Ashraf M, Wang Y. Reduced Collagen Deposition in Infarcted Myocardium Facilitates Induced Pluripotent Stem Cells (iPSC) Engraftment and Angiomyogenesis for Improvement of Left Ventricular Function. Journal of the American College of Cardiology (JACC). 2011;58(20):2118-27. (With Editorial Comment).