Prof. David Allen Hunt

Prof. David Allen Hunt
The College of New Jersey, USA



1979 Ph.D., Duke University, Organic Chemistry
1975 M.S., Marshall University, Organic Chemistry
1973 B.S., Marshall University, Chemistry

Publications (Selected)

  1. Nayak, S.; Fiaschi, M.; King, D.; Tabakin, E. R.; Wood, L.; Hunt, D.A. “Development of small molecular proteasome inhibitors using a Caenorhabditis elegans screen” Int. Med. Chem. vol. 2014, Article ID 237286, 14 pages, 2014. doi:10.1155/2014/237286.
  2. Cherney, E.; Macor, J.; Papanagapolous, C.; Hunt, D.A. “Tandem cyclization reactions of electron rich arylethylamino acid amides. An entry to the dihydroimidazoisoquinolin-3(2H)-one ring system,” Tetrahedron Lett. 2014, 55, 4837-4839.
  3. Geherty, M.; Melnyk, J.; Chomsky, K.; Hunt, D.A. “Halogen-metal exchange reactions of bromoaryl-substituted β-lactams, Tetrahedron Lett. 2013, 54, 4934-4936.
  4. Simpkins, C.; Hunt, D.A. “The Michael addition of 1,2-cyclohexanedione to -nitro- styrenes (I).  The synthesis of 3-aryl-5,6-dihydrobenzofuran-7(4H)-ones,” Tetrahedron Lett. 2013, 54, 3373-3375.
  5. Weinstein, J.D.; Gonzalez, E.R.; Egleton, R.D.; Hunt, D.A. “The 10-patient screening protocol: a paradigm shift for evaluating pharmacotherapy for Alzheimer’s disease,” The Consultant Pharmacist 2013, 28, 443-454.
  6. Bradley, L.M.; Nardone, M.J.; Hunt, D.A. “An expedient in situ preparation of symmetrical 1,4-dibenzylpiperazines from benzyl bromides and 2-bromoethylamine hydrobromide,” Tetrahedron Lett. 2010, 51, 5613-5614.
  7. Bradley, L.M.; Collins, C.G.; Tabakin, E.R.; Hunt, D.A. “Expedient preparations of 4,6-Dihalo-3-arylisobenzofuran-1(3H)-ones from 3,5-dihalo-N-ethylbenzamides,” Org. Prep. Proced. Int. 2010, 42, 187-190.
  8. Deifel, N.P.; Cherney, E.; Hunt, D.A.; Chan, B.C. “1-Methyl-2H-1,3-benzoxazine-2,4(1H)dione” Acta Cryst. 2010, E66, o665.
  9. Hunt, D.A. “Solvent and electronic effects on kinetics of cyclization of thermolabile aryllithium reagents.  A comparison between 1-bromo-2-(2-bromoethyl)benzene and 4,5-dimethoxy-1-bromo-2-(2-bromoethyl)benzene,” Org. Commun. 2009, 2, 60-65.
  10. Clarke A. J.; Hunt, D.A. “-Nitrostyrenes as electrophiles in Parham Cyclization chemistry.  Reaction with o-lithiobenzonitrile,” Tetrahedron Lett. 2009, 50, 2949-2951.
  11. Hunt, D.A. "An improved method for the preparation of 2-(2-aminoaryl)-2-oxazolines from substituted isatoic anhydrides and 2-chloroethylamine hydrochloride," Org. Prep. Proced. Int. 2007, 39, 93-96.
  12. Hunt, D.A. “Condensation of tricyclic pyrrolopyridine diones and an isoindoline dione with methylnitronate anion,” Heterocyclic Commun. 2006, 12, 403-406.
  13. Demas, M.; Javadi, G.J.; Bradley, L.M.; Hunt, D.A. “Metalation of a 3,5-dichloro tertiary benzamide.  An unusual regioselectivity observation,” J. Org. Chem. 2000, 65, 7201-7202.
  14. Henegar K.E.; Hunt, D.A. “Expedient preparations of 2-trifluoromethylindole and its N-methyl derivative,” Heterocycles 1996, 43, 1471-1475.
  15. Hunt, D.A. “2-Arylpyrroles: a new class of insecticide.  Structure, activity, and mode of action,” Pest. Sci. 1996, 47, 201-202.
  16. Barnes, K.D.; Hu, Y.; Hunt, D.A. “Electrophilic fluorination of a highly functionalized pyrrole,” Syn. Commun. 1994, 24, 1749-1755.
  17. Treacy, M.; Miller, T.; Black, B.; Gard, I.; Hunt, D.A.; Hollingworth, R.M. “Uncoupling activity and pesticidal properties of pyrroles,” Biochem. Soc. Trans. 1994, 22, 244-247.
  18. Hunt, D.A. “Michael addition of organolithium compounds.  A review,” Org. Prep. Proced. Int. 1989, 21, 705-749.
  19. Hunt, D.A. “An efficient preparation of 1,2-dihydrocyclobuta-[a]-naphthalene,” Org. Prep. Proced. Int. 1989, 21, 360-363.
  20. Hunt, D.A.; Quante, J.M.; Tyson, R.L.; Dasher, L.W. “The preparation and utilization of corticosteroidal -allylpalladium complexes. A novel entry to 6-,-carboxymethylcortisol,” J. Org. Chem. 1984, 49, 5262-5264.
  21. Bradsher, C.K.; Hunt, D.A. “A novel synthesis of benzo[1,2:4,5] dicyclobutane via a dual Parham Cyclialkylation,” J. Org. Chem. 1981, 46, 4608-4610.
  22. Bradsher C.K.; Hunt, D.A. “Schiff bases as external and internal electrophiles in reactions of functionalized aryllithium reagents. A new route to isoindoline derivatives and 1,2,3,4-tetrahydroisoquinolines,” J. Org. Chem. 1981, 46, 327-330.
  23. Bradsher, C.K.; Hunt, D.A. “A new route to the acridizinium ion,” J. Org. Chem. 1980, 45, 4248-4250.
  24. Reames, D.C.; Hunt, D.A.; Bradsher, C.K. “A one-pot synthesis of some dibenzosuberones via the Parham Cycliacylation reaction,” Synthesis 1980, 454-456.
  25. Hunt, D.A. “A study of the reaction of functionalized aryllithium reagents with internal and external electrophiles.  A pathway to the synthesis of heterocyclic and carbocyclic systems,” Diss. Abstr. Int. B. 1980, 40, 3741.
  26. Bradsher C.K.; Hunt, D.A. “An efficient synthesis of 4,5-dimethoxybenzocyclobutane via the Parham Cyclialkylation reaction,” Org. Prep. Proced. Int. 1978, 10, 267-272.
  27. Parham, W.E.; Bradsher, C.K.; Hunt, D.A. “Reaction of aryllithium reagents with nitriles.  Synthesis of 1-substituted-3,4-dihydroisoquinolines,” J. Org. Chem. 1978, 43, 1606-1607.
  28. Douglass, J.E.; Hunt, D.A. “Synthesis of quinolizinones by the condensation of ylidenemalononitriles with quinoline-1-oxide,” J. Org. Chem. 1977, 42, 3974-3976.