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Biography
Prof. Won-Jea Cho

Prof. Won-Jea Cho

Chonnam National University, South Korea


Email: wjcho@jnu.ac.kr


Qualifications


1994 Post-doc., Univ. of Kansas in USA, Medicinal Chemistry

1991.3 Ph. D., Kanazawa Univ. in Japan, Pharmaceutical Sciences

1988.3 M. S., Kanazawa Univ. in Japan, Pharmaceutical Sciences

1985.2 B. S., Kyung Hee University, Pharmacy


Publication (Selected)

  1. cAMP-dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide, H. Shin, S. D. Hong, E. Roh, S.-H. Jung, W.-J. Cho, S. H. Park, D. Y. Yoon, S. M. Ko, B. Y. Hwang, J. T. Hong, T.-Y. Heo, S.-B. Han and Y. Kim, Br J. Pharmacol., (2015), 172, 3434-3445.
  2. Computer-aided discovery of aminopyridines as novel JAK2 inhibitors, C. Zhao, S. H. Yang, D. B. Khadka, Y. Jin, K.-T. Lee, W.-J. Cho, Bioorg. Med. Chem., (2015), 23, 985-995.
  3. Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition, D. B. Khadka, H. Woo, S. H. Yang, C. Zhao, Y. Jin, T. N. Le, Y. Kwon, W.-J. Cho, Eur. J, Med. Chem., (2015), 92, 583-607.
  4. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors, H. T. M. Van, H. M. Jeong, D. B. Khadka, S. H. Yang, C. Zhao, Y. Jin, K. Y. Lee. Y. Kwon, W.-J. Cho, Eur. J, Med. Chem., (2014),82,181-194.
  5. Design and Evaluation of w-Hydroxy Fattty Acids Containing a-GalCer Analogs for CD1d-Mediated NKT Cell Activation, C. Lim, J. H. Kim, D. J. Baek, J.-Y. Lee, M. Cho, Y.-S. Lee, C.-Y. Kang, D. H. Chung, W.-J. Cho, and S. Kim, ACS Med. Chem. Lett., (2014),5,331-335.
  6. Synthesis of novel 5-oxaprotoberberines as bioisosteres of protoberberines, Y. Jin, D. B. Khadka, S. H. Yang, C. Zhao, W.-J. Cho, Tetrahedron Lett., (2014), 55, 1366-1369.
  7. Scoparone Exerts Anti-Tumor Activity against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity, J.-K. Kim, J.-Y. Kim, H.-J. Kim, K.-G. Park, R.A. Harris, W.-J. Cho, J.-T. Lee, I.K. Lee, Plos One, (2013), 8 (11), e80391.
  8. Identification of daidzein as a ligand of retinoic acid receptor that suppresses expression of matrix metalloproteinase-9 in HaCaT cells, H.-J. Oh, Y-G Kang, T.-Y. Na, H.-J. Kim, J. S. Park, W.-J. Cho, and M.-O. Lee, Mol. Cell. Endocrinol., (2013), 376, 107-113.
  9. (6,7-Dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine (CWJ-082) induces mitotic arrest and apoptotic cell death through the activation of spindle assembly checkpoint in human cervical cancer cells, KS Chung, HE Choi, JS Shin, YW Cho, JH Choi, WJ Cho, KT Lee, Carcinogenesis, (2013), 34 (8), 1852-1860.
  10. SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer, Su-Hui Yang, Chin-Hee Song, Hue Thi My Van, Eunsook Park, Daulat Bikram Khadka, Eun-Yeung Gong, Keesook Lee, and Won-Jea Cho, J. Med. Chem., (2013), 56 (8), 3414-3418.
  11. Topoisomerase Inhibitors as Anticancer Agents: A Patent Update, Daulat Bikram Khadka and Won-Jea Cho, Expert Opin. Ther. Pat.,(2013), 23 (8), 1033-1056.
  12. Hydroquinone regulates hemeoxygenase-1expression via modulation of Src kinase activity through thiolation of cysteine residues. Se Eun Byeon, TaoYu, Yanyan Yang, Yong Gyu Lee, Ji Hye Kim,Jueun Oh, Hye Yoon Jeong, Suntaek Hong, Byong Chul Yoo,Won-Jea Cho, Sungyoul Hong, Jae Youl Cho, Free Radic. Biol. Med., (2013),57, 105-118.
  13. N-Methylthioureas as New Agonists of Retinoic Acid Receptor-Related Orphan Receptor, Yohan Park, Suckchang Hong, Myungmo Lee, Hyojun Jung, Won-Jea Cho, Eun-Jin Kim, Ho-Young Son, Mi-Ock Lee, and Hyeung-geun Park, Arch. Pharm. Res., (2012), 35 (8), 1393-1401.
  14. Structure-Based Virtual Screening and Identification of a Novel AR Antagonist,Chin-Hee Song, Su Hui Yang, Eunsook Park, Suk Hee Cho, Eun-Yeung Gong, Daulat Bikram Khadka, Won-Jea Cho (co corresponding) ,and Keesook Lee, J. Biol. Chem., (2012), 287 (36), 30769-30780.
  15. Orphan nuclear receptor ERRγ is a key regulator of hepatic gluconeogenesis, Don-Kyu Kim, Dongryeol Ryu, Minseob Koh, Min-Woo Lee, Donghyun Lim, Min-Jung Kim, Yong-Hoon Kim, Won-Jea Cho, Chul-Ho Lee, Seung Bum Park, Seung-Hoi Koo &  Hueng-Sik Choi1, J. Biol. Chem., (2012), 287, 21628-21639.
  16. Retinoic Acid Receptor–Related Orphan Receptor a–Induced Activation of Adenosine Monophosphate–Activated Protein Kinase Results in Attenuation of Hepatic Steatosis Eun-Jin Kim, Young-Sil Yoon, Suckchang Hong, Ho-Young Son, Tae-Young Na, Min-Ho Lee, Hyun-Jin Kang, Jinyoung Park, Won-Jea Cho, Sang-Gun Kim, Seung-Hoi Koo, Hyeung-geun Park, and Mi-Ock Lee, Hepatology, (2012), 55 (5), 1379-1388.
  17. Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety, Pritam Thapa, Radha Karki, Minho Yun, Tara Man Kadayat, Eunyoung Lee, Han Byeol Kwon, Youngwha Na, Won-Jea Cho, Nam Doo Kim, Byeong-Seon Jeong, Youngjoo Kwon, Eung-Seok Lee, , Eur. J. Med Chem.,(2012), 52, 123-136 .
  18. Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structureeactivity relationship study, Radha Karki, Pritam Thapa, Han Young Yoo, Tara Man Kadayat, Pil-Hoon Park, Youngwha Na, Eunyoung Lee, Kyung-Hwa Jeon, Won-Jea Cho, Heesung Choi, Youngjoo Kwonc, Eung-Seok Lee, Eur. J. Med Chem., (2012), 49, 219-228.
  19. Synthesis of 12-oxobenzo[c]phenanthridinones and 4-substituted 3-arylisoquinolinones via Vilsmeier-Haack reaction, Daulat Bikram Khadka, Su Hui Yang, Suk Hee Cho, Chao Zhao, Won-Jea Cho, Tetrahedron, (2012), 68, 250-261.
  20. 2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h]quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study, Pritam Thapa, Radha Karki, Han Young Yoo, Pil-Hoon Park, Eunyoung Lee, Kyung-Hwa Jeon, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee, Bioorganic Chemistry, (2012), 40, 67-78.
  21. Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosiase, Pillaiyar Thanigaimalai, Ki-Cheul Lee, Vinay K. Sharma, Cheonik Joo, Won-Jea Cho, Eunmiri Roh, Youngsoo Kim, Sang-Hun Jung, Bioorg. Med. Chem. Lett, (2011), 21 (22), 6824-6828.
  22. Synthetic approaches to natural antioxidant Benzastatin E, F and G analogues, Thanh Nguyen Le, Su Hui Yang, Daulat Bikram Khadka, Suk Hee Cho, Chao Zhao, Won-Jea Cho, Bull. Korean Chem. Soc., (2011), 32 (12), 4309-4315.
  23. Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study, Hue Thi My Van, Daulat Bikram Khadka, Su Hui Yang, Thanh Nguyen Le, Suk Hee Cho, Chao Zhao, Ik-Soo Lee, Youngjoo Kwon, Kyung-Tae Lee, Yong-Chul Kim, Won-Jea Cho, Bioorg. Med. Chem., (2011), 19 (18), 5311-5320.
  24. Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structureeactivity relationship, Uttam Thapa, Pritam Thapa, Radha Karki, Minho Yun, Jae Hun Choi, Yurngdong Jahng, Eunyoung Lee, Kyung-Hwa Jeon, Younghwa Na, Eun-Mi Ha, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee, Eur. J. Med. Chem. (2011), 46, 3201-3209.
  25. Application of Ring-Closing Metathesis for the synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones, Hue Thi My Hue, Daulat Bikram Khadka, Thanh Nguyen Le, Su Hui Yang, Won-Jea Cho, Chem. Pharm. Bull., (2011), 59 (9), 1169-1173.
  26. Development of kNN QSAR Models for 3-Arylisoquinoline Antitumor Agents, Alexander Tropsha, Alexander Golbraikh, Won-Jea Cho, Bull. Korean Chem. Soc., (2011), 32 (7), 2397-2404.
  27. The 3-deoxy ananlogue of a-GalCer: Disclosing the role of the 4-hydroxy group for CD1d-mediated NKT cell activation, Dong Jae Baek, Jeong-Hwan Seo, Chaemin Lim, Jae Hyun Kim, Doo Hyun Chung, Won-Jea Cho, Chang-Yuil Kang, and Sanghee Kim, ACS MedChemLett., (2011), 2 (7), 544-548.
  28. Design, synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling,  Thanh Nguyen Le, Su Hui Yang, Daulat Bikram Khadka, Hue Thi My Van, Suk Hee Cho, Youngjoo Kwon, Eung-Seok Lee, Kyung-Tae Lee, Won-Jea Cho, Bioorg. Med. Chem., (2011), 19, 4399-4404.
  29. Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors, Daulat Bikram Khadka, Quynh Manh Le, Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le, Suk Hee Cho, Youngjoo Kwon, Kyung-Tae Lee, Eung-Seok Lee,  Won-Jea Cho, Bioorg. Med. Chem., (2011), 19 (6), 1924-1929.
  30. 3-Arylisoquinolines as novel topoisomerase I inhibitors, Daulat Bikram Khadka,  Won-Jea Cho, Bioorg. Med. Chem., (2011), 19 (2), 724-734.
  31. Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors, Su Hui Yang, Daulat Bikram Khadka, Suk Hee Cho, Hye-Kyung Ju, Kwang Youl Lee,  Kyung-Tae Lee,  Won-Jea Cho, Bioorg. Med. Chem., (2011), 19 (2), 968-977.
  32. Effects of 3-phenyl-1-isoquinolinamine on the metabolism of beta-amyloid precursor protein in neuroblastoma cells, Jae-Yoon Leem and Won-Jea Cho, Yakhak Hoeji, (2010), 54 (6), 529-534.
  33. CWJ-081, a novel 3-arylisoquinoline derivative, induces apoptosis in human leukemia HL-60 cells partially involves reactive oxygen species through c-Jun NH2-terminal kinase pathway So-Jung Won, Kyung-Sook Chung, Yo Sook Ki, Jung-Hye Choi, Won-Jea Cho, Kyung-Tae Lee, Bioorg. Med. Chem. Lett., (2010), 20 (22), 6447-6451.
  34. Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA, Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le, Daulat Bikram Khadka, Suk Hee Cho, Kyung-Tae Lee, Eung-Seok Lee, Young Bok Lee, Chang-Ho Ahn, Won-Jea Cho, Eur. J. Med. Chem. (2010), 45 (11), 5493-5497.
  35. Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents, Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le, Daulat Bikram Khadka, Suk Hee Cho, Kyung-Tae Lee, Hwa-Jin Chung, Sang Kook Lee, Chang-Ho Ahn, Young Bok Lee, Won-Jea Cho, Bioorg. Med. Chem. Lett., (2010), 20 (17), 5277-5281.
  36. Rational design and evaluation of a branched-chain-containg glycolipid antigen that binds to CD1d, Dong Jae Baek, Yoon-Sook Lee, Chaemin Lim, Doohyun Lee, Taeho Lee, Jae-Young Lee, Kyoo-A Lee, Won-Jea Cho, Chang-Yuil Kang, Sanghee Kim, Chemistry Asian J., (2010), 5 (7), 1560-1566.
  37. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines, Radha Karki, Pritam Thapa, Mi Jeong Kang, Tae Cheon Jeong, Jung Min Nam, Hye-Lin Kim, Youngwha Na, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee, Bioorg. Med. Chem., (2010), 18, 3066-3077.
  38. Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship, Pritam Thapa, Radha Karki, Hoyoung Choi, Jae Hun Choi, Minho Yun, Byeong-Seon Jeong, Mi-Ja Jung, Jung Min Nam, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, and Eung-Seok Lee, Bioorg. Med. Chem., (2010), 18, 2245-2254.
  39. Molecular mechanism of hydroquinone-mediated immunosuppressive effect: Implication of Akt cystein 310 residue as a promising anti-inflammatory drug target site, Ji Yeon Lee, Ae Ra Kim, Keum-Jin Yang, Jongsun Park, Byong Chul Yoo, Sanghee Kim, Won-Jea Cho, and Jae Youl Cho, J. Biol. Chem., (2010), 285 (13), 9932-9948.), 585-589.