Dr. Rosario Osta Pinzolas

Dr. Rosario Osta Pinzolas

University of Zaragoza, Spain



1994 Ph.D., Molecular Genetics, University of Zaragoza

1989 B.Sc., University of Zaragoza

Publications (Selected)

  1. Calvo, J.H. Lopez Corrales, N., Anderson, S.I., Robic, A., Zaragoza, P., Archibald, A. L. y Osta, R., ( 2000). Assignement of TRA1 encoding ppk98 to pig chromosome 5 by fluorescence in situ hybridization and confirmation by somatic cell hybrid analysis. Cytogenetics and Cell Genetics 90 nº 3-4, 321-322.
  2. Calvo, J.H. Zaragoza, P. y Osta R. ( 2001). Ramdom Amplified Polymorphic DNA Fingerprints for identification of species in pate Poultry.Poultry Science 80, 522-524. 
  3. Calvo, J.H. Zaragoza, P. y Osta, R. ( 2001). A quick and more sensitive method to identify pork in processed an unprocessed food by PCR amplification of a new specific DNA fragment.Journal of Animal science 79, 2108-2112.
  4. Roy, R., Gautier, M., Hayes, H., Laurent, P., Eggen, A., Osta, R., Zaragoza, P. & Rodellar, C. (2001)Assignment of the fatty acid sythase (Fasn) gene to bovine chromosome 19 ( 19q22) by in situ hybridization and confirmation by hybrid somatic cell mapping.Cytogenetics and Celll Genetics 93(1-2), 141-142.
  5. Roy, R.,Gautier, M.,Hayes, H.,Laurent, P., Osta, R., Zaragoza, P., Eggen, A., Rodellar, C(2001). Location of the gene for bovine fatty acid synthesis (FASN) on the BTA19 chromosome (19q22). ITEA, 2001,Vol. 22,No. 1,pp. 57-59
  6. Miana-Mena, J., Ciriza, J., Soriano, O., Munoz, M.J., Soria, J., Martin, I., Zaragoza, P. & Osta, R. (2001).El fragmento C de la tóxina tetánica: posibilidades de su uso como vector en terapia génica de enfermedades de la motoneurona. Revista ADELA39 , 26-28.
  7. Miana-Mena, F.J., Roux, S..; Benichou, J.C.; Osta, R. & BRULET, P. (2002).Neuronal activity-dependent membrana traffic at the neuromuscular junction. Pans,99 (nº 5), 3234-3239.
  8. Calvo, J.H., Osta, R & Zaragoza, P. (2002), Quantitative PCR Detection of pork in raw and heated ground beef and pate.J. Agric. Food Chem50, 5265-5267.
  9. Roux, S.; Miana-Mena, F.J.; Osta, R.; Kissa, K.; StCloment, C.; Maskos, U. Brulet, P. (2002). Monintoring intracellular and transneuronal traffic with Toxin Fragments in the mouse Developing CNS. Naunyn-Schmiedeberg's Archives of PharmacologY,365, 2.
  10. Calvo, J.H. Osta, R. & Zaragoza, P ( 2002).Species-specific amplification for detection of Bovine, Ovine an Caprine cheese. Milchwissenshaft 57 (8), 444-446.
  11. Miana-Mena J. Munoz, M.J. Ciriza, J., Soria J., Brulet, P., Zaragoza, P & Osta, R. (2003) Fragment C tetanus toxin: A putative activity-dependent neuroanatomical tracer. Acta Neurobiological Experimentalis 63,211-218.
  12. Miana-Mena, J., Munoz, M.J. Ciriza, J., Rouz, S., Zaragoza, P., BRULET, P. & Osta, Mendez M.(2004). A non-viral vector for targeting gene therapy to motoneurons in the CNS. Neurodegenerative diseases 1: 101-108.
  13. Ciriza J, Miana-Mena J, Moreno M, Valiente M, Martin-Burriel I, Munoz MJ, Zaragoza P, Ojeda MEG, Brulet P, Osta R(2004).Production and functional study of neurotrophic factors fused to C fragment tetanus toxin.Gene Therapy 11, 149.
  14. Miana-Mena FJ, Muñoz MJ, Yagüe G, Mendez M, Moreno M, Ciriza J, Zaragoza P, Osta R.(2005). Optimal methods to characterize the G93A mouse model of A.L.S.
  15. Amyotrophic lateral sclerosis and other motor neuron disorders6 ,55-62
  16. Lyahyai, J., Bolea,R.; Serrano, C., Monleon,E., Moreno, C., Osta, R., Zaragoza, P., Badiola, J.J., Martin-Burriel, I.(2006). Correlation between Bax overexpression and prion deposition in medulla oblongata from natural scrapie without evidence of apoptosis.Acta Neuropathol (Berl)112(4):451-60.
  17. Roux, S, Saint Cloment, C, Curie, T, Girard E, Miana-Mena, FJ, Barbier, J, Osta, R, Molgo, J, Brulet, P.(2006).Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals.Eur J Neurosci. (6):1546-54.
  18. Miana-Mena, I.; Rodellar, C.; Lenstra, J.A.; Sanz, A.; Cons, C.; Osta, R.; Reta, M.; de Argullar, S.; Sanz, A.; Zaragoza, P. (2007) Genetic diversity and relationships of endangered Spanish cattle breeds. Journal of Heredity,98(7):687-91
  19. MUÑOZ, M.J., BEA, J. A., RODRIGUEZ, J. F. OCHOA, I., GRASA, J.-, PEREZ PALOMAR, A., ZARAGOZA, P., OSTA, R., DOBLARE, M. (2008). An experimental study of the mouse skin behaviour. Damage and Inelastic aspects.Journal of Biomechanics, 41(1):93-9.
  20. Ciriza, J; Martín-Burriel, I; García Ojeda M.E.; Agulhon, C, Miana-Mena, F.J.; Muñoz, M.J.; Zaragoza, P.; Brûlet, P and Osta, R. (2008). Antiapototic activity maintenance of Brain Derived Neurotrophic factor and the C fragment of the tetanus toxin fusion protein. Cent. Eur. J. Biol. 3(2), 105-112.
  21. Grasa. J., Ramirez, A., Osta, R., Munoz, M.J. , Soteras, F y Calov, B. (2010). A 3D active-passive numerical skeletal muscle model incorporating initial tissue strains. Validation with experimental results on rat tibialis anterior muscle.Biomechanics and Modeling in Mechanobiology 2010 Dec 3. [Epub ahead of print]
  22. Moreno-Igoa, M, Manzano, R, Oliván, S, Calvo, AC, Toivonen, JM, Osta R (2010).Effects of gene therapy on muscle 18S rRNA expression in mouse model of ALS. BMC Res Notes. 2010 Nov 2;3:275.
  23. toivonen, jm; olivan, s.y Osta, R.(2010).Tetanus toxin C-fragment the courier and the cure?. Toxins 2 (11):2622-2644.
  24. Miana-Mena FJ, González-Mingot C, Larrodé P, Muñoz MJ, Oliván S, Fuentes-Broto L, Martínez-Ballarín E, Reiter RJ, Osta R, García JJ.(2010).Monitoring systemic oxidative stress in an animal model of amyotrophic lateral sclerosis. J Neurol. 2010 Nov 25. [Epub ahead of print]
  25. Miana-Mena FJ,Piedrafita-Trigo, E.,González-Mingot C, Larrodé P, Muñoz MJ, Oliván S, Fuentes-Broto L, Martínez-Ballarín E, Reiter RJ, Osta R, García JJ(2011).Levels of membrane fluidity in the spinal cord and the brain in an animal model of amyotrophic lateral sclerosis.J Bioenerg Biomembr. 2011 Mar 31. [Epub ahead of print]
  26. MANZANO, R., TOIVONEN, J.M., OLIVAN, S., CALVO, A.C., MUÑOZ, M.J., ZARAGOZA, P. , GARCIA-REDONDO, A. y OSTA, R. (2011). Expression of myogenic regulatory factors during disease progression in mouse model of amyotrophic lateral sclerosis.Neurodegener Dis. 2011 Feb 23. [Epub ahead of print]
  27. Renzo Mancuso R., Santos-Nogueira , E., Osta , R., Navarro, X.(2011). Electrophysiological analysis of a murine model of motoneuron diseaseClin Neurophysiol. 2011 Feb 24. [Epub ahead of print]
  28. Ranera, B., Ordovás, L; Lyahyai, J; Bernal, M L; Fernandes, F; Remacha, A; Romero, A; Vázquez, F; Osta, R; Cons, C; Varona, L; Zaragoza, P; Martin-Burriel, Ia; Rodellar, C,(2011).Comparative study of equine bone marrow- and adipose tissue-derived mesenchymal stromal cells. Equine Veterinary Journal (in press).
  29. Calvo AC, Moreno-Igoa M, Mancuso R, Manzano R, Oliván S, Muñoz MJ, Penas C, Zaragoza P, Navarro X, Osta R.(2011).Lack of a synergistic effect of a non-viral ALSgene therapy based on BDNF and a TTC fusion molecule. Orphanet J Rare Dis. Mar 21;6:10. PubMed PMID: 21418619.
  30. Manzano R, Toivonen JM, Calvo AC, Muñoz MJ, Zaragoza P, Osta R. (2011). Housekeeping gene expression in myogenic cell cultures from neurodegeneration and denervation animal models. Biochem Biophys Res Commun. 2011 Mar 31. PubMed PMID: 21439935.
  31. Manzano R, Toivonen JM, Calvo AC, Muñoz MJ, Zaragoza P, Osta R. (2011).Quantity and activation of myofiber-associated satellite cells in a mouse model of amyotrophiclateral sclerosis. Stem Cell reviews and reports.