Lian LI

Prof. Lian Li

School of Medicine

Emory University, USA



1991 Ph.D., Biochemistry, University of California

1985 M.Sc., Physical Chemistry, Xiamen University

1982 B.Sc., Xiamen University

Publications (Selected)

  1. Li, L., Schuchard, M., Palma, A., Pradier, L., & McNamee, M. G. (1990) gFunctional role of the Cys-451 thiol group in the M4 helix of the subunit of Torpedo californicaacetylcholine receptor. Biochemistry, 29:5428-5436.
  2. Eterovic, V. A., Li, L. Palma, A., & McNamee, M. G. (1990) Regulation of nicotinic acetylcholine receptor function by adenine nucleotides. Cell. & Molec. Neurobiology, 10: 423-433.
  3. Ochoa, E.L.M., Li, L., Plummer, A., & McNamee, M. G. (1990) Direct effects of thymopentin (Arg-Lys-Asp-Val-Tyr) on cholinergic agonist-induced slow inactivation of nicotinic acetylcholine receptor function. Molecular Pharmacology 38: 863-871.
  4. Palma, A., Li, L., Chen, X. Pappone, P., and McNamee, M. G. (1991) Effects of pH on acetylcholine receptor function. J. Membrane Biology 120: 67-73.
  5. Li, L. & McNamee, M. G. (1992) Modulation of nicotinic acetylcholine receptor channel by pH: A difference in pH sensitivity ofTorpedoand mouse receptors expressed inXenopusoocytes.Cell. & Molec. Neurobiology, 12: 83-93.
  6. Li, L., Lee, Y-H., Pappone, P., Palma, A., & McNamee, M. G. (1992) Site-specific mutations of nicotinic acetylcholine receptor at the lipid-protein interface dramatically alter ion channel gating. Biophys. J. 62: 61-63.
  7. Ochoa, E.L.M., Li, L., & McNamee, M. G. (1992)  Neuroadaptation tonicotine: possible role of desensitization of central cholinergic mechanisms in the development of tolerance, dependence and withdrawal. Molecular Neurobiology,4: 251-287
  8. Eterovic, V. A., Li, L. Ferchmin, P. A., Lee, Y. H., Hann, R. M., & McNamee, M. G. (1993) The ion channel of muscle and electric organ acetylcholine receptors: differing affinities for noncompetitive inhibitors.Cell. & Molec. Neurobiology, 13: 111-121.
  9. Eterovic, V. A., Hann, R. M., Ferchmin, P. A., Rodriguez, A. D., Li, L. Lee, Y. H., & McNamee, M. G. (1993) Diterpenoids from Caribbean gorgonians act as  noncompetitive inhibitors of the nicotinic acetylcholine receptor. Cell. & Molec. Neurobiology, 13: 99-110.
  10. Li, L., Suzuki, T., Mori, N., & Greengard, P. (1993) Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proc. Natl. Acad. Sci. USA 90: 1460-1464.
  11. Lee, Y-H., Li, L., Lasalde, J., Rojas, L., McNamee, M. G., Ortiz-Miranda, S., & Pappone, P. (1994) Mutations in the M4 domain at the lipid-protein interface of  Torpedo californicaacetylcholine receptor dramatically alter ion channel Function. Biophys. J. 66: 646-653.
  12. Chin, L.-S., Li, L., & Greengard, P. (1994) Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements. J. Biol. Chem.269: 18507-18513.
  13. Li, L., Chin, L-S., Shupliakow, O., Brodin L., Sihra, T., Hvalby, O., Jensen, V., Zheng, D., McNamara, J. O., Greengard, P., &Andersen, P.(1995) Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. Proc. Natl. Acad. Sci. USA  92: 9235-9239.
  14. Chin, L.-S., Li, L., Ferreira, A., Kosik, K. S., & Greengard, P. (1995) Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc. Natl. Acad. Sci. USA  92: 9230-9234.
  15. Li, L., Chin, L. -S., Greengard, P., Copeland, N. G., Gilbert, D. J., & Jenkins, N. A. (1995) Localization of the synapsin II gene to human chromosome 3 and mouse chromosome 6. Genomics  28: 365-366.
  16. Ferreira, A., Li, L., Chin, L.-S., Greengard, P., & Kosik, K. S. (1996) Aretarded competence of the postsynaptic element is responsible for the delay in synaptogenesis observed in synapsin I-deficient neurons. Molec. & Cell. Neurosci. 8: 286-299.
  17. Ryan, T. A., Li, L., Chin, L.-S., Greengard, P., & Smith, S. J. (1996). Synaptic vesicle recycling in synapsin I knockout mice. J. Cell Biol. 134:1219-1227.
  18. Ferreira, A., Chin, L.-S., Li, L., Lanier, L. M., Kosik, K. S. &Greengard, P.(1998)Distinct roles of synapsin I and synapsin II during neuronal development. Molecular Medicine 4: 22-28.
  19. Chin,L-S., Fu, Q., Kachinsky, A. M., Jabren, G., Niu, Y. & Li, L. (1999) Neuron-specific and developmental regulation of the synapsin II gene expression in transgenic mice. Brain Res. Mol. Brain Res. 67: 239-246.
  20. Walaas, S. I., Hilfiker, S., Li, L., Chin, L.-S., & Greengard, P. (2000) Decrease in phorbol ester-induced potentiation of noradrenaline release in synapsin I-deficient mice. Synapse 36:114-119.
  21. Chin,L-S., Nugent, R. D., Raynor, M. C., Vavalle, J. P. & Li, L. (2000) SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. J. Biol. Chem. 275: 1191-1200.
  22. Kwong, J., Roudabush, F. L., Moore, P. H., Montague, M., Oldham, W., Li, Y., Chin, L-S., & L. Li. (2000) Hrs interacts with SNAP-25 and regulates Ca2+-dependent exocytosis. J. Cell Sci. 113:2273-2284.
  23. Chin,L-S., Weigel, C., & Li, L. (2000) Transcriptional regulation of gene expression of Sec6, a component of mammalian exocyst complex at the synapse. Brain Res. Mol. Brain Res.79: 127-137.
  24. Li, Y., Chin,L-S., Weigel, C., & Li, L. (2001) Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. J. Biol. Chem. 276: 40824-40833.
  25. Chin,L-S., Raynor, M. C., Wei, X., Chen, H-Q., & Li, L. (2001) Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J. Biol. Chem. 276: 7069-7078.
  26. Li, Y., Chin,L-S., Levey, A. I., & Li, L. (2002) Huntingtin-associated protein 1 interacts with Hrs and functions in endosomal trafficking.J. Biol. Chem. 277: 28212-28221.
  27. Ahn, K., Yeyeodu, S., Collette, J., Madden, V., Arthur, J., Li, L., & Erickson, A. H. (2002) An alternate targeting pathway for procathepsin L in mouse fibroblasts. Traffic 3: 147-159.
  28. Wheeler, T. C., Chin, L-S., Li, Y., Roudabush, F. L., & Li, L. (2002) Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J. Biol. Chem. 277: 10273-10282.
  29. Chin L-S., Vavalle J. P., & Li, L. (2002) Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. J. Biol. Chem. 277: 35071-35079.
  30. Huai, Q., Sun, Y., Wang, H., Chin L-S., Li, L., Robinson, H. & Ke, H. (2003) Crystal structure of DJ-1/RS and implication on familial Parkinson’s disease. FEBS Lett. 549: 171-175.