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Biography

Prof. Yuin-Han Jonathan Loh

Institute of Molecular and Cell Biology (IMCB)

Children's Hospital Boston, USA


Email: yhloh@imcb.a-star.edu.sg


Qualifications

2008-2011 Post-doctoral Fellowship, Stem cell Biology, Harvard Medical School

2003-2008 Ph.D., Biological Chemistry and Molecular Pharmacology, National University of Singapore

1999-2002 B.Sc., Cellular and Molecular Biology, National University of Singapore


Publications (Selected)

  1. Loh, Y. H., Wu, Q., Chew, J. L., Vega, V. B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., Wong, K. Y., Sung, K. W., Lee, C. W., Zhao, X. D., Chiu, K. P., Lipovich, L., Kuznetsov, V. A., Robson, P., Stanton, L. W., Wei, C. L., Ruan, Y., Lim, B., and Ng, H. H. (2006). The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genetics 38, 431–440. Epub 2006 Mar 5.
  2. Agarwal, S., Loh, Y. H., McLoughlin, E. M., Huang, J., Park, I. H., Miller, J. D., Huo, H., Okuka, M., dos Reis, R. M., Loewer, S., Ng, H. H. Keefe, D. L., Goldman, F. D., Klingelhutz, A. J., Liu, L., Daley, G. Q. (2010) Telomere elongation in dyskeratosis congenital induced pluripotent stem cells. Nature464, 292-296. Epub 2010 Feb 17.
  3. Loh, Y. H., Hartung, O., Li, Hu., Guo C., Sahalie, J. M., Manos P. D., Urbach, A., Heffner G. C., Grskovic, M., Vigneault, F., Lensch M. W, Park I. H., Agarwal, S., Church, G. M., Collins, J. J., Irion, S., Daley, G. Q. (2010). Reprogramming of T Cells from Human Peripheral Blood. Cell Stem Cell 7, 15-19.
  4. Loh, Y. H., Zhang, W., Chen, X., George, J., Ng, H. H. (2007). Jmjd1a and Jmjd2c histone H3 lysine 9 demethylases regulate self-renewal in embryonic stem cells. Genes and Development 21, 2545-2557.
  5. Loh, Y. H., Agarwal, S., Park, I. H., Urbach, A., Park, I. H., Heffner, G.C., Kim, K., Miller, J. D., Ng, K., Daley G.Q. (2009). Generation of induced pluripotent stem cells from human blood. Blood. 113, 5476-5479. Epub 2009 Mar 18.
  6. Jiang, J., Chan, Y. S., Loh, Y. H.*, Cai, J., Tong, G. Q., Lim, C. A., Robson, P., Zhong, S., Ng, H. H. (2008). A core Klf circuitry that regulates self-renewal of embryonic stem cells.Nature Cell Biology 10, 353-360. Epub 2008 Feb 10.
  7. Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y. H.*, Lau, F., Ebina, W., Smith, Z. D., Li, H., Collins, J. J., Meissner, A., Daley, GQ., Brack, A. S., Cowan, C., Schlaeger, T. M., Rossi, D.J. (2010). Highly efficient reprogramming to pluripotency and directed differentiation using synthetic mRNA. Cell Stem Cell 7(5):618-30. Epub 2010 Sep 30.
  8. Loh, Y. H.*, Ng, J. H, Ng, H. H. (2008). Molecular framework underlying pluripotency Cell Cycle 7: 7, 1-8. Invited Review.
  9. Loewer, S., Cabili, M., Guttman, M., Loh, Y. H., Thomas, K., Park, I. H., Garber, M., Curran, M., Manos, P. D., Agarwal, S., Onder, T., Datta, S., Lander, E. S., Schlaeger, T. M., Daley, GQ., Rinn, J. L.(2010). Large intergenic non-coding RNAs as novel modulators of reprogramming. Nature Genetics42(12):1113-7. Epub 2010 Nov 7. Paper was featured in Preview by Huck-Hui Ng (Dec 2010)Nature Genetics 42(12).
  10. Chan E. M., Ratanasirintrawoot S., Park I. H., Manos P. D., Loh Y. H., Huo H., Miller J. D., Hartung O., Rho J., Ince T. A., Daley G. Q., Schlaeger T.M. (2009) Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nature Biotechnology. 27, 1033-1037. Epub 2009 Oct 11.
  11. Chen, X. Xu, H., Yuan, P., Fang, F., Huss, M., Vega, V., Wong, E., Orlov, Y., Zhang, W., Jiang, J., Loh, Y. H., Yeo, H. C., Yeo, Z. H., Narang, V., Govindarajan, K.R., Leong, B., Shahab, A., Ruan, Y., Bourque, G., Sung, W.K., Clarke, N., Wei, C.L., Ng, H.H. (2008) Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 13; 133(6):1106-17.
  12. Chew, J. L., Loh, Y. H.*, Zhang, W., Chen, X., Tam, W. L., Yeap, L. S., Li, P., Ang, Y. S., Lim, B., Robson, P., and Ng, H. H (2005). Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Molecular and Cellular Biology 25, 6031-6046.
  13. Lim, L. S., Loh, Y. H.*, Zhang, W., Li, Y., Chen, X., Wang, Y., Bakre, M., Ng, H. H., and Stanton, L. W. (2007). Zic3 Is Required for Maintenance of Pluripotency in Embryonic Stem Cells. Molecular Biology of the Cell 18, 1348-1358. Epub 2007 Jan 31.
  14. Feng, B., Jiang, J., Kraus, P., Ng, J.H., Heng, J.C., Chan, Y.S., Yaw, L.P., Zhang, W., Loh, Y.H., Han, J., Vega, V.B., Cacheux-Rataboul, V., Lim, B., Lufkin, T., Ng, H.H. (2009). Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nature Cell Biology. 11(2):197-203. Epub 2009 Jan 11.
  15. Yuan P., Han J., Guo G., Orlov Y. L., Huss M., Loh Y. H., Yaw L. P., Robson P., Lim B., Ng H.H. Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes and Development 23, 2507-2520.
  16. Ng, J. H., Heng, J. C. D., Loh, Y. H.*, Ng, H. H. (2008) Epigenetic and Transcriptional regulation of stem cells. Mutat Res. 1; 647(1-2):52-8. Epub 2008 Aug 20. Invited Review.
  17. Rodda, D.J., Chew, J. L., Lim, L. H., Loh, Y. H., Wang, B., Ng, H. H., and Robson, P. (2005). Transcriptional regulation of Nanogby OCT4 and SOX2. Journal of Biological Chemistry 280, 24731–24737. Epub 2005 Apr 27.
  18. Wu, Q., Chen, X., Zhang, J., Loh, Y. H., Low, T. Y., Zhang, W., Zhang, W., Sze, S. K., Lim, B., and Ng, H. H. (2006). Sall4 interacts with Nanog and co-occupies Nanog genomic sites Gore, A., Li, Z., Fung, H. L., Young, J., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Israel, M., Kiskinis, E., Lee, J. H., Loh, Y. H., Manos P.D., Montserrat, N., Wilbert, M., Yu, J., Kirkness, E., Belmonte, J. C. I, Daley, G. Q., Eggan, K., Rossi, D. J., Thomson, J., Goldstein, L. S. B., Zhang, K. (2010). Somatic coding mutations in human induced pluripotent stem cells. Nature.
  19. Kim, K., Zhao, R., Doi, A., Ng, K., Unternaehrer, J., Cahan, P., Hongguang, H., Loh, Y. H., Aryee, J. M., Feinberg, P. A., Daley, G. Q., Epigenetic memory in human induced pluripotent stem cells. Nature Biotechnology.