Dr. Valentina Echeverria

Dr. Valentina Echeverria

Bay Pines Veterans Affairs Healthcare System, USA



1999 Ph.D., University of Concepcion

1994 M.S., University of Concepcion

Publications (selected)

  1. Echeverria V and Zeitlin R. Neuroinflammatory Factors as Targets Against Neurological and Psychiatric Conditions. In: "Neuroinflammation: Pathogenesis, Mechanisms and Management". NOVA Science Publishers. 2011.
  2. Echeverria V and Zeitlin R. Cotinine: Implications in Neurological and Psychiatric Disorders. In: “Working Memory: Capacity, Developments and Improvement Techniques”. NOVA Science Publishers. Dec, 2011.
  3. Echeverria V, Zeitlin R, Burgess S, Zeitlin R, Barman A, Thakur G, Inouye H, Feris E, Sattelle D, Kirschner DA, Mori T, Leblanc R, Prabhakar R, and Arendash G. Cotinine Reduces Amyloid b Aggregation and Improves Memory in Alzheimer’s Mice. J Alzheimer’s Disease. 2011.
  4. Burgess S, Echeverria V. Raf Inhibitors as Therapeutic Agents against Neurodegenerative Diseases. CNS. Neurol. Disord. Drug Targets. 9(1): 120-7, 2009.
  5. Echeverria V, Burgess S, Gamble-George J, Zeitlin RS, Mamcarz M, Cao C, Arendash GW. Sorafenib inhibited cRaf-1/NFkB pathway and restored working memory in aged APPswe mice. Neuroscience. 162, (4): 1220-1231, 2009.
  6. Arendash GW, Mori T, Mamcarz M, Dickson A, Runfeldt M, Rezai-Zadeh K, Citron B, Tan J, Lin X, Cao Ch, Echeverria V, and Potter H. Caffeine reverses cognitive impairment and decreases brain Aβ levels in aged Alzheimer’s mice. J. Alzheimer’s Disease. 17(3): 661-80, 2009.
  7. Echeverria V, Burgess S, Gamble-George J, Arendash GW, Citron AB. Raf inhibition is Neuroprotective against Amyloid b toxicity. Neuroscience Letters. Oct 17; 444(1): 92-96, 2008.
  8. Citron, BA, Dennis, JS, Zeitlin, RS, Echeverria V. Transcription factor Sp1 dysregulation in Alzheimer’s Disease. J Neuroscience Res. Aug 15; 86(11): 2499-504, 2008.
  9. Echeverria V, Powell D, Arancio O. Oligomers of b-amyloid peptide block BDNF-induced Arc expression in cultured cortical neurons. Current Alzheimer Research. 4(5): 518-52, 2007.
  10. Ahmad M, Saalem S, Zhuang H, Echeverria V, Sapirstein A, Doré, S. 1-hydroxyPGE1 reduces infarction volume in mouse transient cerebral Ischemia. European Journal Neuroscience. 23(1): 35-42, 2006.
  11. Echeverria V, Clerman A, Doré, S. Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure. European Journal Neuroscience. 22(9): 2199-206, 2005.
  12. Echeverria V, Ducatenzeiler A, chen H, Cuello AC. Endogenous beta-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells. Neuroscience. 135(4): 1193-202, 2005.
  13. Cuello AC, Bell KFS, Echeverria V, Lopez E, Ribeiro-da-Silva A, Szyf, M. The impact of extracellular amyloid-b (Ab) peptides on cortical neurotransmitters and of intracellular Ab accumulation on protein expression. In Recent progress in Alzheimer’s and Parkinson’s Diseases. Hanin, I, Cacabelos R and Fisher A Ed. Taylor & Francis London and NY. 44: 347-354, 2005.
  14. Echeverria, V, Greenberg LD, Doré, S. Expression of Prostaglandin E2 Synthases in mouse postnatal cortical neurons. Ann NY Acad Sci. 1053: 460-71, 2005.
  15. Echeverria V, Dowd E., Ducatenzeiler A, Alohen L, Janne J, Grant S, Muro A, Baralle F, Li H, Hartmann, T, Cuello, AC. Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience. 129(3): 583, 2004.
  16. Echeverria V, Ducatenzeiler A, Alohen L, Janne J, Grant S, Wandosell F, Muro A, Baralle F, Li H, Duff K, Szyf M, Cuello AC. Rat transgenic models with a phenotype of intracellular Ab accumulation in hippocampus and cortex. J. Alzheimer’s Disease. 6(3): 209–19, 2004.
  17. Echeverria V, Cuello AC. Intracellular Ab amyloid, a sign for worse things to come? Mol Neurobiol. 26(2-3): 299–316, 2002.
  18. Ledo F, Link W, Carrión A, Echeverría V, Mellstrom B, Naranjo JR. The DREAM-DRE interaction:key nucleotides and dominant negative mutants. Biochemica et Biophysica Acta. 14676: 1–7, 2000.
  19. Echeverría V, Hinrichs MV, Torrejón M, Ropero S, Toro MJ, Olate J. Mutagenesis in the switch IV of the helical domain of the human Gsa reduces its GDP/GTP exchange rate. J Cell Biochem. 76(3): 368–375, 1999.
  20. Torrejón M, Geneviere A.M, Echeverría V, Guzmán L, Hinrichs M, Olate J. The C2 cytosolic loop of adenylyl cyclase interacts with the activated form of Gsa. FEBS Letters. 441: 437–440, 1998.
  21. Torrejón M, Echeverría V, Retamales G, Herrera L, Hinrichs M, Olate J. Molecular cloning and expression of an adenylyl cyclase from Xenopus laevis oocytes. FEBS Letter. 404: 91–94, 1997.
  22. Echeverría V, Olate J, Cid H. Partial DNA Sequence of a b-lactamase produced by a Shigella flexneri strain. Microbios. 83: 107–117, 1995.
  23. Echeverría V, Mondaca MA, Montoya R, Bunster M, Cid H. Characterization of a plasmid codifying the synthesis of a b-lactamase produced by Shigella flexneri. Microbios. 76: 161–166, 1993.