Dr. Cheng-Xin Gong

Dr. Cheng-Xin Gong

New York State Institute for Basic Research in Developmental Disabilities, USA



1988 M.D., Tongji Medical University

1983 M.S., Xianning Medical College

Publications (selected)

  1. Liu, F, Iqbal, K, Grundke-Iqbal, I, Hart, GW, and Gong, CX. O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease. Proc Natl Acad Sci USA. 2004; 101: 10804-10809.
  2. Liu, F, Iqbal, K, Grundke-Iqbal, I, Rossie, S, Gong, CX. Dephosphorylation of tau by protein phosphatase 5: Impairment in Alzheimer disease. J. Biol. Chem. 2005; 280: 1790-1796.
  3. Liu, F, Grundke-Iqbal, I, Iqbal, K, Oda, Y, Tomizawa, K, Gong, CX. Truncation and activation of calcineurin A by calpain l in Alzheimer disease brain. J. Biol. Chem. 2005; 280: 37755-37762.
  4. Deng, Y, Li, B, Liu, F, Iqbal, K, Grundke-Iqbal, I, Brandt, R, Gong, CX. Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease. FASEB J. 2008; 22 (1): 138-45.
  5. Liu F, Liang Z, Wegiel J, Hwang YW, Iqbal K, Grundke-Iqbal I, Ramakrishna N, Gong CX. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB J. 2008; 22 (9): 3224-33.
  6. Liu F, Shi J, Tanimukai H, Gu J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer disease. Brain 2009; 132: 1820-32.
  7. Deng Y, Li B, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. Am J Pathol. 2009; 175 (5): 2089-2098.
  8. Gong, C.-X., Grundke-Iqbal, I., Iqbal, K. Targeting tau protein in Alzheimer disease. Drug Aging. 2010; 27 (5): 351-65.
  9. Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Deficient brain insulin signaling pathway in Alzheimer’s disease and diabetes. J Pathol. 2011; 225 (1): 54-62.
  10. Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TRW, Purvine SO, Wang Z, Camp II DG, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD. Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including targets of an EGF domain-specific O-GlcNAc transferase. Proc Natl Acad Sci USA. 2012; 109 (19): 7280-7285.
  11. Gong CX, Liu F, Iqbal K. O-GlcNAc cycling modulates neurodegeneration. Proc Natl Acad Sci U S A. 2012; 109 (43): 17319-20.
  12. Yang Y, Ma D, Wang Y, Jiang T, Hu S, Zhang M, Yu X, Gong CX. Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of Type 2 Diabetes. J Alzheimers Dis. 2013; 33: 329-338.
  13. Jin N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease. Nucleic Acids Res. 2013; 41: 3240-3256.
  14. Dai CL, Shi J, Chen Y, Iqbal K, Liu F, Gong CX. Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT). J Biol Chem. 2013; 288 (33): 23875-83.
  15. Yang Y, Zhang J, Ma D, Zhang M, Hu S, Shao S, Gong CX. Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with Type 2 Diabetes. J Alzheimers Dis. 2013; 37: 637-648.
  16. Gong CX, Alonso Adel C. Tau and beyond for Alzheimer's disease. J Alzheimers Dis. 2013; 37 (3): 465-466.
  17. Chen Y, Liang Z, Tian Z, Blanchard J, Dai CL, Chalbot S, Iqbal K, Liu F, Gong CX. Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice. Mol Neurobiol. 2014; 49 (1): 547-62.
  18. Zhao Y, Gu JH, Dai CL, Liu Q, Iqbal K, Liu F, Gong CX. Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice. Front Aging Neurosci. 2014; 6: 10.
  19. Chen Y, Zhao Y, Dai CL, Liang Z, Run X, Iqbal K, Liu F, Gong CX: Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice. Exp Neurol 2014; 261: 610-619.
  20. Chen Y, Run X, Liang Z, Zhao Y, Dai CL, Iqbal K, Liu F, Gong CX: Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice. Front Aging Neurosci. 2014; 6: 100.
  21. Yuzwa SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman MA, Watson NV, Gong CX, Vocadlo DJ. Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. Mol Neurodegener 2014; 9: 42.
  22. Jin N, Yin X, Yu D, Cao M, Gong CX, Iqbal K, Ding F, Gu X, Liu F. Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Sci Rep. 2015 Feb 2; 5: 8187.

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