Karam F.A. Soliman, PhD

Prof. Karam F.A. Soliman

College of Pharmacy and Pharmaceutical Sciences

Florida A&M University, USA




1972 Ph.D., University of Georgia, Physiology (Endocrinology)

1971 M.S., University of Georgia, Physiology

1964 B.S., Cairo University

Publications (selected)

  1. Mazzio EA, A Becker and KFA Soliman. Inflammation and inducible nitric oxide synthase have no effect on monoamine oxidase activity in glioma cells. Biochem Pharmacol. 15: 65: 1719-1927 (2003).
  2. Mazzio EA and KFA Soliman. Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. Neurochem Res. 28(5): 733-741 (2003).
  3. Sircar R and KFA Soliman. Effects of postnatal PCP treatment on locomotor behavior and striatal D(2) receptor. Pharmacol Biochem Behav. 74(4): 943-452(2003).
  4. Mazzio E and KFA Soliman. The role of glycolysis and gluconeogenesis in the cytoprotection of neuroblastoma cells against 1-methyl 4-phenylpyridinium ion toxicity. Neurotoxicology. 24: 137-147 (2003).
  5. Mazzio E and KFA Soliman Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro. Neurosci Lett. 6; 337: 77-80.
  6. Mazzio E, KJ Yoon and KFA Soliman. Acetyl-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells, Biochemical Pharmacology, 66: 297-306 (2003).
  7. Mazzio E and KFA Soliman. Glioma cell capacity in removing generated reactive oxygen species. Journal of Applied Toxicology. 24: 99-106 (2004).
  8. Mazzio E and KFA Soliman. Effect of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-pheylpyridinium toxicity in neuroblastoma cells. Biochemical Pharmacology 67: 1167-1184 (2004).
  9. Lee E, H Chen, KR Shephard, N Lamango, KFA Soliman and CG Charlton. Inhibitory Effects of lysophosphatidylcholine on the dopaminergic system. Neurochemical Research 29: 1325-1334 (2004).
  10. Lee E, H Chen, KR Shephard, N Lamango, KFA Soliman and CG Charlton. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neuroscience Research 48: 335-344 (2004).
  11. Mazzio E, RR Reams and KFA Soliman. The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro. Brain Research 1004: 29-44 (2004).
  12. Yoon K, K Redda, E Mazzio, and KFA Soliman. Inhibitory effects of novel tetrahydropyridine derivatives on nitric oxide and reactive oxygen species in glioma cells. Drug Development Research 61: 189-196 (2004).
  13. Mazzio E, MG Kolta, RR Reams, and KFA Soliman. Inhibitory effects of cigarette smoke on glial inducible nitric oxide synthase and lack of protective properties against oxidative neurotoxins in vitro. Neurotoxicology 26: 49-62 (2005).
  14. Lee E, KFA Soliman and CG Charlton. Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats. Neurotoxicology 26: 27-38 (2005).
  15. Elsisi N, S Darling-Reed, EY Lee, ET Oriaku and KF Soliman. Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. Neuroscience Letters 375: 91-96 (2005).
  16. Lee E, H Chen, KFA Soliman and CG Charlton. Effects of Homocysteine on the Dopaminergic System and behavior in Rodents. Neurotoxicology 26: 361-371 (2005).
  17. Lee E, H Chen, CG Charlton and KFA Soliman. The Role of Phospholipid Methylation in 1-Methyl-4-Phenyl-Pyridinium ion (MPP+) induced Neurotoxicity in PC12 cells. Neurotoxicology 26, 945-957(2005).
  18. KR Shepherd, EY Lee, L Schmued, SF Ali C, ET Oriaku, NS Lamango, KFA Soliman, and CG Charlton. The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on paraquat-induced neurochemical and behavioral changes in mice. Pharmacology Biochemistry Behavior 83: 349-59 (2006).
  19. Lee E, Z Williams, C Goodman, ET Oriaku, M Thomas, C Harris and KFA Soliman. Effects of NMDA Receptor Inhibition by Phencyclidine on the Neuronal Differentiation of PC12 Cells. Neurotoxicology. 27: 558-66 (2006).
  20. Williams ZR, Goodman CB, and Soliman KFA. Anaerobic Glycolysis Protection Against 1-methy 4-phenylpyridinium (MPP+) Toxicity in C6 Glioma Cells. In press. J Neurochemical Research (2007).
  21. Mazzio E and Soliman KF. In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs. Phytotherapy Research 23: 385-398 (2009).
  22. Soliman Y I. Mazzio E, Jackson T and Soliman KF. "The effects of piroxicam in the attenuation of MPP+/MPTP toxicity in vitro and in vivo. Neurochemical Research 34: 304-310 (2009).
  23. Becker A, Soliman KF. The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells. Neurochem Res. 34: 1677-1684. 2009.
  24. Reams RR, D Agrawal, MB Davis, S Yoder, FT Odedina, N Kumar, JM Higginbotham, T Akinremi, S Suther and KFA Soliman. Microarray Comparison of Prostate Tumor Gene Expression In African-American and Caucasian American Males: A Pilot Project Study. BioMed Central 10:4 Supp 1S: 3 (2009).
  25. Mazzio E, Soliman KF. Evaluation of endogenous acidic metabolic products associated with anaerobic carbohydrate metabolism in tumor cells. Cell Biol Toxicology 26: 177-188 (2010).