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Biography

Name: Sachin Gajghate

Title: Assistant Scientist

Affiliation: Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, USA

Email: SACHIN.GAJGHATE@TEMPLE.EDU


Research fields:

· Chronic Inflammatory Lung Diseases

· Chronic Obstructive Pulmonary Disease

· Chronic Respiratory Disease

· Respiratory Medicine

· Respiratory Tract Infections

· Therapeutic Advances in Respiratory Disease

· Blood brain barrier and HIV infection

· Disc degeneration


Qualifications:

2003 M.Sc., Nagpur University, Biochemistry, India

2001 B.Sc., Nagpur University, Biochemistry, India

1998 D.Pharm, Mumbai Technical board, India


Publications:

1) Slava Rom, Nathan A Heldt, Sachin Gajghate, Alecia Seliga, Nancy L Reichenbach, Yuri Persidsky. Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles. Sci Rep. 2020 Oct

2) William D Cornwell, Uma Sriram, Alecia Seliga, Viviana Zuluaga-Ramirez, Sachin Gajghate, Slava Rom, Malika Winfield, Nathan A Heldt, David Ambrose, Thomas J Rogers, Yuri Persidsky. Tobacco smoke and morphine alter peripheral and CNS inflammation following HIV infection in a humanized mouse model. Sci Rep. 2020 August

3) Slava Rom, Sachin Gajghate, Malika Winfield, Nancy L Reichenbach, Yuri Persidsky. Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes. Int J Mol Sci. 2020 Jul

4) Slava Rom, Nathan A Heldt, Sachin Gajghate, Alecia Seliga, Nancy L Reichenbach, Yuri Persidsky. Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles Sci Rep. 2020 Apr

5) Nathan A Heldt, Alecia Seliga, Malika Winfield, Sachin Gajghate, Nancy Reichenbach, Xiang Yu, Slava Rom, Amogha Tenneti, Dana May, Brian D Gregory, Yuri Persidsky. Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation. Brain Behav Immun. 2020 August

6) Bernstein DL, Gajghate S, Reichenbach NL, Winfield M, Persidsky Y, Heldt NA, Rom S. let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model. Brain Behav Immun. 2020 Feb

7) Bernstein, David; Zuluaga-Ramirez, Viviana; Gajghate, Sachin; Reichenbach, Nancy; Polyak, Boris; Persidsky, Yuri; Rom, Slava. miR-98 reduces endothelial dysfunction by protecting blood brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model Journal of Cerebral Blood Flow and Metabolism 2019 Oct

8) Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Persidsky Y. Chronic Intrahippocampal Infusion of HIV-1 Neurotoxic Proteins: A Novel Mouse Model of HIV-1 Associated Inflammation and Neural Stem Cell Dysfunction. J Neuroimmune Pharmacol. 2019 Sep

9) Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Sriram U, Rom S, Persidsky Y. Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation. Brain Behav Immun. 2019 Feb

10) Rom S, Zuluaga-Ramirez V, Gajghate S, Seliga A, Winfield M, Heldt NA, Kolpakov MA, Bashkirova YV, Sabri AK, Persidsky Y. Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models. Mol Neurobiol. 2019 Mar

11) Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Persidsky Y. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug

12) Rom S, Zuluaga-Ramirez V, Reichenbach NL, Erickson MA, Winfield M, Gajghate S, Christofidou-Solomidou M, Jordan-Sciutto KL, Persidsky Y. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation 2018 Jan

13) Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Holly Dykstra, Sachin Gajghate, Pal Pacher and Yuri Persidsky: PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood brain barrier. J Neuroinflammation. 2018 Jul

14) Anju Singh, Sreedhar Venkannagari, Kyu Oh, Ya-Qin Zhang, Jason Rohde, Li Liu, Sridhar Nimmagadda, Kuladeep Sudini, Kyle Brimacombe, Sachin Gajghate, Jinfang Ma, Amy Wang, Xin Xu, Sampada Shahane, Menghang Xia, George Mensah, Zhibin Wang, Marc Ferrer, Edward Gabrielson, Zhuyin Li, Fraydoon Rastinejad, Min Shen, Matthew Boxer, Shyam Biswal: Specific small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance of KEAP1 deficient NSCLC tumors. ACS Chemical Biology. 2018 Nov

15) Thomas E Sussan, Sachin Gajghate, Pooja Mandke, Samit Chatterjee, Sarah McCormick, Kuladeep Sudini, Venkataramana K Sidhaye, Shyam Biswal: Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. Am J Physiol Lung Cell Mol Physiol. 2015 Jul