Dr. Zufeng Guo

Department of Pharmacology and Molecular Sciences

Johns Hopkins University School of Medicine, USA

Research Associate



2010-present Ph.D., Johns Hopkins University School of Medicine, Baltimore, USA

2003-2010 Ph.D., Hong Kong University of Science and Technology, Hong Kong, China

2000-2003 M.S., Fuzhou University, Fuzhou, China

1996-2000 B.S., Fuzhou University, Fuzhou, China

Publications (Selected)

  1. Guo, Z.F.; Hong, S.; Wang, J.X.; Rehan, S.; Liu, W.K.; Peng, H.J.; Das, M.; Li, W.; Bhat, S.; Peiffer, B.; Ullman, B.R.; Tse, C.M.; Tarmakova, Z.; Schiene-Fischer, C.; Fischer, G.; Coe, I.; Paavilainen, V.O.; Sun, Z.L.; Liu, J.O. Rapamycin-inspired macrocycles with new target specificity. Nat. Chem. accepted.
  2. Kosowicz, J.G.; Lee, J.; Peiffer, B.; Guo, Z.F.; Chen, J.M.; Liao, G.L.; Hayward, S.D.; Liu, J.O.; Ambinder, R.F. (2017) Drug modulators of B cell signaling pathways and Epstein-Barr virus lytic activation. J. Virol. 91, e00747-17.
  3. McClary, B.; Zinshteyn, B.; Meyer, M.; Jouanneau, M.; Pellegrino, S.; Yusupova, G.; Schuller, A.; Reyes, J.C.; Lu, J.Y.; Guo, Z.F.; Ayinde, S.; Luo, C.; Dang, Y.J.; Romo, D.; Yusupov, M.; Green, R.; Liu, J.O. (2017) Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chem.Biol. 24, 605-613.
  4. Haynes, R.K.; Cheu, K.-W.; Chan, H.-W.; Wong, H.-N.; Li, K.-Y.; Tang, M.M.-K.; Chen, M.-J.; Guo, Z.-F.; Guo, Z.-H.; Sinniah, K.; Witte, A.B.; Coghi, P.; Monti, D. (2012) Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model - A Unifying Proposal for Drug Action. ChemMedChem 7, 2204-2226.
  5. Haynes, R.K.; Cheu, K.-W.; Li, K.-Y.; Tang, M.M.-K.; Wong, H.-N.; Chen, M.-J.; Guo, Z.-F.; Guo, Z.-H.; Coghi, P.; Monti, D. (2011) A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine. ChemMedChem 6, 1603-1615.
  6. Haynes, R.K; Cheu, K.-W.; Tang, M.M.-K.; Chen, M.-J.; Guo, Z.-F.; Guo, Z.-H.; Coghi, P.; Monti, D. (2011) Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified. ChemMedChem 6, 279-291.
  7. Chen, M.; Jiang, M.; Sun, Y.; Guo, Z.-F.; Guo, Z. (2011) Stabilization of the Second Oxyanion Intermediate by 1,4-Dihydroxy-2-naphthoyl- Coenzyme A Synthase of the Menaquinone Pathway: Spectroscopic Evidence of the Involvement of a Conserved Aspartic Acid. Biochemistry 50, 5893-5904.
  8. Jiang, M.; Chen, M.J.; Guo, Z.-F.; Guo, Z. (2010) A Bicarbonate Cofactor Modulates 1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis of Escherichia coli. J. Biol. Chem. 285, 30159-30169.
  9. Chen, X.L.; Guo, Z.-F.; Lai, P.M.; Sze, K.H.; Guo, Z. (2010) Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027. Angew. Chem. Int. Ed. 49, 7926-7928.
  10. Guo, Z.-F.; Jiang, M.; Zheng, S.; Guo, Z. (2010) Structural change of the enterobactin synthetase in crowded solution and its relation to crowding-enhanced product specificity in nonribosomal enterobactin biosynthesis. Bioorg. Med. Chem. Lett. 20, 3855-3858.
  11. Guo, Z.-F.; Sun, Y.; Zheng, S.; Guo, Z. (2009) Preferential hydrolysis of aberrant intermediates by the type II thioesterase in Escherichia coli nonribosomal enterobactin synthesis: substrate specificities and mutagenic studies on the active site residues. Biochemistry 48, 1712–1722.
  12. Gao, Y.; Kuang, Y.; Guo, Z.-F.; Guo, Z.; Krauss I.J.; Xu, B. (2009) Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative. J. Am. Chem. Soc. 131, 13576-13577.
  13. Guo, Z.-F.; Jiang, M.; Zheng, S.; Guo, Z. (2008) Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis. Org. Lett. 10, 649–652. (C&EN Sci. & Tech. concentrate highlight: news/86/i06/8606news5.html).
  14. Jiang, M.; Chen, X.; Guo, Z.-F.; Cao, Y.; Chen, M.; Guo, Z. (2008) Identification and characterization of (1R, 6R)-2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli. Biochemistry 47, 3426–3434.
  15. Yang, Z. M.; Xu, K. M.; Guo, Z. -F.; Guo, Z.; Xu, B. (2007) Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death. Adv. Mater. 19, 3152–3156.
  16. Jiang, M.; Cao, Y.; Guo, Z.-F.; Chen, M.; Chen, X.; Guo. Z. (2007) Menaquinone biosynthesis in Escherichia coli: Identification of 2-succinyl-5-enolpyruvyl- 6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) as a novel intermediate and re-evaluation of MenD activity. Biochemistry 46, 10979–10989.
  17. Yang, Z.; Liang, G.; Guo, Z.F.; Guo, Z.; Xu, B. (2007) Intracellular hydrogelation of small molecules inhibits bacterial growth. Angew. Chem. Int. Ed. 46, 8216–8219.
  18. Tong, H.; Hong, Y. N.; Dong, Y. Q.; Haussler, M.; Lam, J. W. Y.; Li, Z.; Guo, Z.F.; Guo, Z.; Tang, B. Z. (2006) Fluorescent "light-up" bioprobes based on tetraphenylethylene derivatives with aggregation-induced emission characteristics. Chem. Commun. 35, 3705–3707.
  19. Zhong, X.; Guo, Z.F.; Yang, H.; Peng, L.; Xie, Y.; Wong, T.-Y.; Lai, S.-T.; Guo, Z. (2006) Amino terminus of the SARS coronavirus protein 3a elicited strong, potentially protective humoral responses in infected patients. J. Gen. Virol. 87, 369–374.
  20. Zhong, X.; Yang, H.; Guo, Z.-F.; Sin, W.-Y. F.; Chen, W.; Xu, J.; Fu L.; Wu, J.; Mak, C.-K.G.; Cheng, C.-S.S.; Yang, Y.; Cao S.; Wong, T.-Y.; Lai, S.-T.; Xie, Y.; Guo, Z. (2005) B cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein. J. Virol. 79, 3401–3408.
  21. Ouyang, X.; Xie, Z.; Guo, Z.F.; Lin, X.; Guo, L. (2004) Study of direct fluorophotometric and flow-injection fluorophotometric methods based on the inhibitory effect for the determination of trace formaldehyde. Spectrosc. Spect. Anal. 24, 1395-1399.