Dr. Yuncai Chen

School of Medicine

University of California at Irvine, USA



2003 Post-doc, University of California, Anatomy/Neurobiology

1996 Post-doc, Peking University, Neuroanatomy

1994 Ph.D., Sun Yat-sen University, Anatomy/Neurobiology

Publications (Selected)

  1. Xu B, Sun A, He Y, Qian F, Liu L, Chen Y, Luo H. Running induced memory enhancement correlates with the preservation of thin spines in the hippocampal area CA1 of old C57BL/6 mice. Neurobiology of Aging, 2017. DOI: [Epub ahead of print].
  2. Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ. Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses. J Neurosci. 2016; 36:11295-11307.
  3. Chen Y, Molet J, Gunn BG, Ressler K, Baram TZ. Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons. Endocrinology, 2015;156:4769-4780. doi: 10.1210/en.2015-1673.
  4. Chen Y, Baram TZ. Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks. Neuropsychopharmacology 2016; 41:197-206. doi: 10.1038/npp.2015.181. Review.
  5. Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice. J Neurochem. 2015; 134:915-26. doi: 10.1111/jnc.13195.
  6. Maras PM, Molet J*, Chen Y*, Rice C, Ji SG, Solodkin A, Baram TZ. Preferential loss of dorsal-hippocampus synapses underlies memory impairment provoked by short, multimodal stress. Mol Psychiatry, 2014; 19:811-822. doi: 10.1038/mp.2014.12. (*contributed equally).
  7. Cope JL*, Regev L*, Chen Y*, Korosi A, Rice CJ, Ji S, Rogge GA, Wood MA, Baram TZ. Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress, 2014, 17(1):39-50. (*contributed equally).
  8. Andres AL, Regev L, Phi L, Seese RR, Chen Y, Gall CM, and Baram TZ. NMDA Receptor Activation and Calpain Contribute to Disruption of Dendritic Spines by the Stress Neuropeptide CRH. J Neurosci, 2013, 33: 16945-16960.
  9. Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, and Wood MA. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci, 2013, 16(5):552-561. doi: 10.1038/nn.3359.
  10. Chen Y, Kramár EA, Chen LY, Babayan AH, Andres AL, Gall CM, Lynch G, and Baram TZ. Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry, 2013, 18(4):485-496.
  11. Noam Y, Phan L, McClelland S, Manders EM, Wadman WJ, Baram TZ, and Chen Y. Distinct regional and subcellular localization of the actin-binding protein filamin A in rat brain. J Comp Neurol, 2012, 520: 3013-3034.
  12. Chen Y, Andres AL, Frotscher M and Baram TZ. Tuning synaptic transmission in the hippocampus by stress: the CRH system. Front Cell Neurosci, 2012, 6:13. Epub 2012 April 03. doi: 10.3389/fncel.2012.00013.
  13. Marcelin B*, Liu Z*, Chen Y*, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram TZ, Esclapez M, and Bernard C. Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells. J Neurosci, 2012, 32(11):3736-3747. (*contributed equally).
  14. Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, and Schmidt MV. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiol Dis, 2011, 42:300-310.
  15. Chen Y, Rex CS, Rice CJ, Dubé CM, Gall CM, Lynch G, and Baram TZ. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci USA, 2010, 107:13123-13128.