Dr. Cuihua Wang

Center for Systems Biology

Harvard Medical School,USA

Research Fellow

Email: wang.cuihua@mgh.harvard.edu

Qualifications

2006 Ph.D., Peking University, Organic Chemistry

2000 B.Sc., Qingdao University, Chemical Engineering

Publications (Selected)

1. Lowe, M.M.; Mold, J.E.; Kanwar, B.; Huang, Y.; Louie, A.; Pollastri, M.P.; Wang, C.; Patel, G.; Franks, D.G.; Schlezinger, J.; Sherr, D.H.; Silverstone, A.E.; Hahn, M.E.; MaCune, J.M.; Identification of Cinnabarinic Acid as Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production.PLoS One2014, 9(2), e87877
2. Wang, C.; Ashton, T.D.; Gustafson, A.; Bland, N.D. Ochiana, S.O.; Campbell, R.K.; Pollastri, M.P. Synthesis and Evaluation of Human Phosphodiesterases (PDE5) Inhibitor Analogs as Trypanosomal PDE Inhibitors. 1. Sildenafil Analogs.Bioorg. Med. Chem. Lett. 2012, 22(7), 2579-81.
3. Ochiana, S.O.; Gustafson, A.; Bland, N.D.; Wang, C.; Russo, M.J.; Campbell, R.K.; Pollastri, M.P. Synthesis and Evaluation of Human Phosphodiesterases (PDE5) Inhibitor Analogs as Trypanosomal PDE Inhibitors. 2. Tadalafil Analogs.Bioorg. Med. Chem. Lett.2012, 22(7), 2582-84.
4. Bland, N.D.; Wang, C.; Tallman, C.; Gustafson, A.E.; Wang, Z.; Ashton, T.D.; Ochiana, S.O.; McAllister, G.; Cotter, K.; Fang, A.P.; Gechijian, G.; Garceau, N.; Gangurde, R.; Ortenberg, R.; Ondrechen, M.J.; Campbell, R.K.; Pollastri, M.P. Pharmacological Validation of Trypanosoma Brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness.J. Med. Chem.2011,54, 8188-8194.
5. Barluenga, S.; Fontaine J.G.; Wang, C.; Aouadi, K.; Chen, R.; Beebe, K.; Neckers, L. and Winsinger, N. Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights.ChemBioChem, 2009, 2753-2759.
6. Wang, C.; Barluenga, S.; Gisish K. K.; Fontaine, J.G.; Chen, R.; Yu, J.; Shen, X.; Chabala, J.; Heck, J.; Rubenstein, A.; Winssinger, N. Synthesis of Pochoxime Prodrugs as Potent HSP90 Inhibitors.Bioorg. Med. Chem. Lett.,2009, 3836-3840.
7. Barluenga S.; Wang, C.; Fontaine, J.G.; Aouadi, K.; Beebe, K.; Tsutsumi, S.; Neckers, L.; Winssinger, N. Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified InhibitorAngew. Chem. Int. Ed., 2008,47, 4432-4435.
8. Li, C.; Wang, C.; Liang, B.; Zhang, X.; Deng, L.; Liang, S.; Chen, J.; Wu, Y.; Yang, Z. Synthetic Study of 1,3-Butadiene-Based IMDA Approach to Construct a [5-7-6] Tricyclic Core and Its Application to the Total Synthesis of C8-epi- Guanacastepene O.J. Org. Chem.2006, 71(18), 6892-6897.
9. Wang, C.; Hu, R.; Liang, S.; Chen, J.; Yang, Z. and Pei, J. Linear C2-Symmetric Polycyclic Benzodithiophene: Efficient, Highly Diversified Approaches and the Optical Properties.Tetrahedron. Lett.,2005,46,8153-8157.
10. Dai M.; Liang B.; Wang, C.; You Z.; Xiang J.; Dong G.; Chen J.; Yang Z. A Novel Thiourea Ligand Applied in the Pd-Catalyzed Heck, Suzuki and Suzuki Carbonylative Reactions.Adv. Synth. & Catal. 2004,346, 1669-1673.
11. Dai, M.; Liang, B,; Wang, C.; Chen, J.; Yang, Z.; Synthesis of a Novel C2-Symmetric Thiourea and Its Application in the Pd-Catalyzed Cross-Coupling Reactions with Arenediazonium Salts under Aerobic Conditions.Org. Lett.,2004, 6(2),221-224.
12. Dai, M. ; Wang, C.; Dong, G. ; Xiang, J. ; Luo, T. ; Chen, J. ; Yang, Z. Development of Thiourea-based Ligands for the Palladium-Catalyzed Bis-(methoxycarbonylation) of Terminal Olefins.Eur. J. Org. Chem.2003, 4346-4348.