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Biography


Prof. Hiroyuki Shibata

Akita University, Japan


Email: hiroyuki@med.akita-u.ac.jp


Qualifications


1991 Ph.D., Tohoku University, Japan

1987 M.D., Tohoku University, Japan

1987 B.Sc., Tohoku University, Japan


Publications (selected)

  1. Lin L, Liu Y, Li H, Li P-K, Shibata H, Iwabuchi Y, Lin J. (2011) Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030. Br J Cancer, 105, 212 – 220.
  2. Yoshioka T, Kato S, Gamoh M, Chiba N, Suzuki T, Sakayori N, Kato S, Shibata H, Shimodaira H, Otsuka K, Kakudo Y, Takahashi S, Ishioka C (2009) Phase I/II study of sequential therapy with irinotecan and S-1 for metastatic colorectal cancer. Br J Cancer, 101, 1972-1977.
  3. Shibata H, Takano H, Ito M, Shioya H, Hirota M, Matsumoto H, Kakudo Y, Ishioka C, Akiyama T, Kanegae Y, Saito I, Noda T (2007) a-Catenin is essential in intestinal adenoma formation. Proc Natl Acad Sci U S A., 104, 18199-18204.
  4. Ohori, H., Yamakoshi, H., Tomizawa, M., Shibuya, M., Kakudo, Y., Takahashi, A., Takahashi, S., Kato, S., Suzuki, T., Ishioka, C., Iwabuchi, Y., Shibata, H.(2006) Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol Cancer Ther, 5, 2563-2571
  5. Kakudo Y, Shibata H, Otsuka K, Kato S, Ishioka C. (2005) Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s. Cancer Res. 65, 2108-2114.
  6. Kato S, Han SY, Liu W, Otsuka K, Shibata H, Kanamaru R, Ishioka C. (2003) Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci U S A. 100, 8424-8429.
  7. Gallagher RC, Hay T, Meniel V, Naughton C, Anderson TJ, Shibata H, Ito M, Clevers H, Noda T, Sansom OJ, Mason JO, Clarke AR. (2002) Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene. 21, 6446-6457.
  8. Hasegawa S, Sato T, Akazawa H, Okada H, Maeno A, Ito M, Sugitani Y, Shibata H, Miyazaki Ji J, Katsuki M, Yamauchi Y, Yamamura Ki K, Katamine S, Noda T. (2002) Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc Natl Acad Sci U S A. 99, 297-302.
  9. Han SY, Kato H, Kato S, Suzuki T, Shibata H, Ishii S, Shiiba K, Matsuno S, Kanamaru R, Ishioka C. (2000) Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res. 60, 3147-3151.
  10. Shimodaira H, Filosi N, Shibata H, Suzuki T, Radice P, Kanamaru R, Friend SH, Kolodner RD, Ishioka C. (1998) Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae. Nature Genet. 19, 384-389.
  11. Shibata H, Toyama K, Shioya H, Ito M, Hirota M, Hasegawa S, Matsumoto H, Takano H, Akiyama T, Toyoshima K, Kanamaru R, Kanegae Y, Saito I, Nakamura Y, Shiba K, Noda T. (1997) Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science. 3, 278, 120-123.

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