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Biography

Prof. Shen Hu

Division of Oral Biology and Medicine, University of California, USA

Jonsson Comprehensive Cancer Center, University of California, USA

MS Program Director and Admission Chair

Associate Professor


Email: shenhu@ucla.edu


Qualifications

1996 Ph.D., Wuhan University, Bioanalytical Chemistry, China

1991 B.Sc., Wuhan University, Chemistry, China


Publications (Selected)

  1. Shen Hu, Arjan Vissink, Martha Arellano, et al. Identification of autoantibody biomarkers for primary Sjögren’s syndrome using protein microarrays. Proteomics, 2011, 11(8):1499-507
  2. Arjan Vissink, Hendrika Bootsma, Fred KL Spijkervet, Shen Hu, et al. Current and future challenges in primary Sjögren’s syndrome. Current Pharmaceutical Biotechnology, 2012 Jan 2. [Epub ahead of print].
  3. Xiaojun Liu, David Chai, Kaori Misuno, Min Zhang, Shen Hu. Tissue, serum and saliva sampling for proteomic analysis. In Comprehensive Sampling and Sample Preparation, Volume 3; Pawliszyn, J.; Le, X. C.; Li, X-F.; Lee, H. K.; Eds; Elsevier, Academic Press: Oxford, UK, pp 359–364, 2012.
  4. Jeff Brumbaugh, Robert Ferris, Shen Hu. “HPV and EBV in head and neck cancer”. Head and Neck Cancer: Multimodality Management. Edited by Jacques Bernier, Springer Science, pp 121-134, September 2011.
  5. Xiaofeng Zhou, Shen Hu, David T. Wong. “High throughput molecular profiling approaches for the identifications of genomic alterations and therapeutic targets in oral cancer”. Signaling Pathways in Squamous Cancer, Edited by Carter van Waes and Adam Glick, Springer Science, pp 431-452, October 2011.
  6. David Elashoff D, Hui Zhou, Jane Reiss, Jianghua Wang, Hua Xiao, Brad Henson, Shen Hu, Martha Arellano, et al. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012, 21(4):664-72.
  7. Shen Hu, Arjan Vissink, Martha Arellano, et al. Validation of protein biomarkers for primary Sjögren’s syndrome. Arthritis Care Research, 2010, 62(11):1633-8.
  8. Martha Arellano-Garcia, Roger Li, Xiaojun Liu, Yongmin Xie, Xinmin Yan, Joseph Loo, Shen Hu. Identification of tetranectin as a potential biomarker for metastatic oral cancer. International Journal of Molecular Science. 2010;11(9):3106-21.
  9. Yi Liu, Lina Wang, Xuedong Zhou, Shen Hu, Siyu Zhang, Hongkun Wu. Effect of antimicrobial decapeptide (KSL) on the growth of oral bacteria and protein expression in Streptococcus mutans. International Journal of Antimicrobial Agents, 2011;37(1):33-8.
  10. Xiaojun Liu, Paul W.N. Lee, Vai-liang W. Go, Shen Hu. Membrane proteomic analysis of pancreatic cancer cells. Journal of Biomedical Science. 2010,17:74.
  11. Yi Liu, Diana Messadi, Hongkun Wu, Shen Hu. Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer. Medical Hypothesis, 2010, 75(6):492-4.
  12. Shen Hu, Michael Zhou, Jiang Jiang, Jianghua Wang, David Elashoff, Sven Gorr, Sara A. Michie, Fred KL Spijkervet, Hendrika Bootsma, Cees GM Kallenberg, Arjan Vissink, Steve Horvath, David T. Wong. Systems biologic analysis of Sjögren’s syndrome and mucosaassociated lymphoid tissue (MALT) lymphoma. Arthritis & Rheumatism, 2009, 60(1): 81-92.
  13. Shen Hu*, David T. Wong. Lectin microarray. Proteomics/Clinical Applications, 2009, 3:148–154.
  14. Kai Gao, Hui Zhou, Lei Zhang, Jin Wook Lee, Qing Zhou, Shen Hu, Lawrence E. Wolinsky, James Farrell, Guido Eibl, David T. Wong. Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. PLoS One. 2009, 4(6): e5875.
  15. Fang Wei, Prabhudas Patel, Wei Liao, Kishore Chaudhry, Lei Zhang, Martha Arellano, Shen Hu, David Elashoff, Hui Zhou, Shilin Shukla, Franky Shah, Chih-Ming Ho, David T. Wong. Electrochemical sensor for multiplex biomarkers detection. Clinical Cancer Research 2009, 15(13): 4446-52.
  16. Martha Arellano, Jiang Jiang, Xiaofeng Zhou, Lifeng Zhang, Hui Ye, David Wong, Shen Hu*. Current advances in identification of cancer biomarkers in saliva. Frontiers in Bioscience, 2009, 1:296-303.
  17. Shen Hu, Jiang Jiang, David Wong. “Proteomic analysis of saliva: 2-D gel electrophoresis, Western blotting and LC-MS”. Methods in Molecular Biology. Edited by M. Cullinan et al. Humana Press, 2010;666:31-41.
  18. Jiang Jiang,NojinPark, Shen Hu, David T. Wong. A universal pre-analytic solution for concurrent stabilization of salivary proteins, RNA and DNA at ambient temperature. Arch Oral Biology 2009, 54(3): 268-73.
  19. Weihong Yan, Rolf Apweiler, Brian M. Balgley, Pinmanee Boontheung, Jonathan L. Bundy, Benjamin J. Cargile, Steve Cole, Xueping Fang, Mireya Gonzalez-Begne, Timothy J. Griffin, Fred Hagen, Shen Hu, Lawrence E. Wolinsky, Cheng S. Lee, Daniel Malamud, James E. Melvin, Rajasree Menon, Michael Mueller, Renli Qiao, Nelson L. Rhodus, Joel R. Sevinsky, David States, James L. Stephenson, Jr., Shawn Than, John R. Yates, III, Weixia Yu, Hongwei Xie, Yongming Xie, Gilbert S. Omenn, Joseph A. Loo, David T. Wong. Systematic comparison of the human saliva and plasma proteomes. Proteomics Clinical Applications 2009, 3(1): 116-134.
  20. Reuben H. Kim, Roy Kim, Wei Chen, Shen Hu, Ki-Hyuk Shin,No-HeeParkand Mo K.Kang. Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells. Carcinogenesis. 2008, 29(12): 2425-31.
  21. Shen Hu*, Martha Arellano, Pinmanee Boontheung, Jianghua Wang, Hui Zhou, Jiang Jiang, David Elashoff, Roger Wei, Joseph A. Loo, David T. Wong*. Salivary proteomics for oral cancer biomarker discovery. Clinical Cancer Research, 2008, 14(19): 6246-52.
  22. Martha Arellano, Shen Hu, Jianghua Wang, Hui Zhou, David Wong. Multiplexed immunobead-based assay for detection of oral cancer protein biomarkers in saliva. Oral Diseases, 2008, 14(8): 705-12.
  23. Lifeng Zhang, Jiang Jiang, David Wong, Shen Hu. Quantitative proteomic analysis of serum proteins from metastatic oral cancer patients. The Open Proteomics Journal, 2008, 1:72-78.
  24. Hui Ye, Anxun Wang, Bao-shiang Lee, Tianwei Yu, Shihu Shen, Tingsheng Peng, Shen Hu, David L. Crowe, Xiaofeng Zhou. “Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma”. Cancer Genomics & Proteomics, 2008, 5: 85-94.
  25. Paul Denny, Fred K. Hagen, Markus Hardt, Lujian Liao, Weihong Yan, Martha Arellanno, Sara Bassilian, Gurrinder S. Bedi, Pinmannee Boontheung, Daniel Cociorva, Claire M. Delahunty, Trish Denny, Jason Dunsmore, Kym F. Faull, Joyce Gilligan, Mireya Gonzalez-Begne, Frédéric Halgand, Steven C. Hall, Xuemei Han, Bradley Henson, Johannes Hewel, Shen Hu, Sherry Jeffrey, Jiang Jiang, Joseph A. Loo, Rachel R. Ogorzalek Loo, Daniel Malamud,James E. Melvin, Olga Miroshnychenko, Mahvash Navazesh, Richard Niles, Sung Kyu Park,Akraporn Prakobphol, Prasanna Ramachandran, Megan Richert, Sarah Robinson, Melissa Sondej, Puneet Souda, Mark A. Sullivan, Jona Takashima, Shawn Than, Jianghua Wang, Julian P. Whitelegge, Ewa Witkowska, Lawrence Wolinsky, Yongming Xie, Tao Xu, Weixia Yu, Jimmy Ytterberg, David T. Wong, John R. Yates, III, Susan J. Fisher. The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. Journal of Proteome Research, 2008, 7(5): 1994-2006.
  26. Shen Hu, Jianghua Wang, Jisha Meijer, Sonya Ieong, Hui Zhou, Arjan Vissink, David Elashoff, Joseph Loo, David Wong. “Salivary proteomic and genomic biomarkers for primary Sjögren's Syndrome”. Arthritis & Rheumatism, 2007, 56 (11), 3588–600.
  27. Shen Hu, David Wong. “Oral cancer proteomics”. Current Opinion in Molecular Therapeutics, 2007 9(5): 467-76.
  28. Shen Hu, Tianwei Yu, Yongming Xie, Yanan Yang, Joseph Loo, David Wong. “Discovery of oral fluid biomarkers for human oral cancer using mass spectrometry”. Cancer Genomics and Proteomics, 2007, 4(2): 55-64.
  29. Shen Hu, Yun Yen, David Ann, David Wong. “Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery”. Drug Discovery Today, 2007, 12, 911-916.
  30. Jianghua Wang, Shen Hu, David T. Wong. “Salivary biomarkers for the detection of primary Sjögren's Syndrome”. Future Rheumatology, 2007, 2(5), 447-449.