Dr. Matthew S. Halquist

Bioanalytical Shared Resource Laboratory, Department of Pharmaceutics

School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA

Research Assistant Professor/Director



2012 Ph.D., Virginia Commonwealth University, Pharmaceutical Sciences

1998 B.S., Virginia Commonwealth University, Science (Biology focus) Minors, Chemistry and Forensics Science

Publications (Selected)

  1. Farthing, C, Halquist MS, Sweet, DS. A Simple High-Performance Liquid Chromatographic Method for the Simultaneous Determination of Monoamine Neurotransmitters and Relative Metabolites with Application in Mouse Brain Tissue. Journal of Liquid Chromatography and Related Technologies. 2015, 38(12): 1173-1178.
  2. M Guarnieri, C Brayton, L DeTolla, N Forbes-McBean, B Tyler, R Sarabia-Estrada, M S Halquist, T Karnes. Safety Studies of Postsurgical Buprenorphine Therapy for Mice. Laboratory Animals. 2015, 49(2): 100-110.
  3. Wang M, Halquist MS, Zhang Y, Gerk PM. Simultaneous determination of lopinavir and three ester prodrugs by LC-MS/MS in lysates of BeWo cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2015, (975): 84-90.
  4. Priya P. Nadkarni, Matthew S. Halquist, H. Thomas Karnes, Richard M. Costanzo and Masahiro Sakagami. Pulmonary delivery of anorectic oxyntomodulin in rats: food intake suppression, reduced body weight gain and pharmacokinetics. Therapeutic Delivery. 2015, (3): 297-306.
  5. Chojnacki, Jeremy; Liu, Kai; Yan, Xing; Toldo, Stefano; Selden, Tyler; Estrada, Martin; Rodríguez-Franco, María Isabel; Halquist, MS; Abbate, Antonio; Ye, Dexian; Zhang, Shijun. Discovery of 5-(4-Hydroxyphenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide as a Neuroprotectant for Alzheimer's Disease by Hybridization of Curcumin and Melatonin. ACS Chem Neurosci. 2014, 5(8): 690-699.
  6. Faria, Morse; Halquist, Matthew; Yuan, Moucum; Mylott, William; Jenkins, Rand; H. Thomas, Karnes. Comparison of a stable isotope labeled (SIL) peptide and an extended SIL peptide as internal standards to track digestion variability of an unstable signature peptide during quantification of human osteopontin from plasma using capillary microflow LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. Submitted July 2014.
  7. Marchetti C, Toldo S, Chojnacki J, Mezzaroma E, Liu K, Salloum FN, Nordio A, Carbone S, Mauro AG, Das A, Zalavadia AA, Halquist MS, Federici M, Van Tassell BW, Zhang S, Abbate A. Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and non-ischemic injury in the mouse. Journal of Cardiovascular Pharmacology. [Epub ahead of print], PMID: 25915511.
  8. Faria M, Halquist MS, Yuan M, Mylott W Jr, Jenkins RG, Karnes HT. An extended stable isotope labeled signature peptide internal standard for tracking immunocapture of human plasma osteopontin for LC-MS/MS quantification. Biomedical Chromatography, doi: 10.1002/bmc.3471. [Epub ahead of print], PMID: 25919310.
  9. Li Wang, Matthew S. Halquist, Douglas Sweet. Simultaneous determination of gallic acid and gentisic acid in organic anion transporter expressing cells by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013, (937): 91-96.
  10. Matthew S. Halquist, Masahiro Sakagami, and H. Thomas Karnes. Determination of oxyntomodulin, an anorectic gut-secreting peptide, in rat plasma using a multiply-charged state and two-dimensional reversed phased ion pair chromatography tandem mass spectrometry. Poster presented at the 2012 AAPS Annual Meeting & Exposition.
  11. Wenlin Li, Xiaolin Kang, Erick Kindt, Cathy Zang, Zhengming Yan, Michael Eisenbraun, Mark Elliot, J. Alan Arbuckle, H. Thomas Karnes, Matthew S. Halquist, Morse Faria, Peter J. O’Brien. A simplified approach to measuring Thymidine Kinase activity in cells, tumors, and blood as a biomarker of tumor proliferative potential. Poster presented at the American Association for Cancer Research 2012.
  12. Morse Faria, Matthew Halquist and Thomas Karnes. Preliminary studies for the quantification of human osteopontin using dual immunocapture coupled with tandem mass spectrometry. Presented at the School of Pharmacy Research Day and Career Day, Virginia Commonwealth University, 2012.
  13. Meng Wang, Matthew S. Halquist and Phillip M. Gerk. LC-MS/MS Method for analysis of uptake of ester prodrugs of lopinavir into BeWo Trophoblast Cells. Presented at the School of Pharmacy Research Day and Career Day, Virginia Commonwealth University, 2012.
  14. Matthew S. Halquist and H. Thomas Karnes. Investigation of Factors Affecting Charge State Distribution and Selected Reaction Monitoring for Quantification of Intact Polypeptides in Human Plasma Using LC-MS/MS. Poster presented at the 2011 AAPS Annual Meeting & Exposition.
  15. Morse Faria, Matthew S. Halquist, Wenlin Li, Mark Elliott, Xiaolin Kang, Cathy Zhang, Peter J. O’ Brien and H. Thomas Karnes. Liquid chromatography tandem mass spectrometry method for quantification of thymidine kinase 1 activity in human serum by monitoring the conversion of3’deoxy-3’-fluorothymidine to3’deoxy-3’-fluorothymidine monophosphate. Poster presented at the 2011 AAPS Annual Meeting & Exposition.
  16. Matthew S. Halquist, Richard Beardsley, Surendra Bansal, H. Thomas Karnes. Quantification of Alefacept (Amevive) by Liquid Chromatography Tandem Mass Spectrometry using a Protein Analogue Internal Standard (Myoglobin) and Enzymatically Cleaved Peptides in Human Plasma. Poster presented at the 2010 AAPS Annual Meeting & Exposition.
  17. Shah, K. A., Peoples, M. C., Halquist, M. S. and Karnes, H. T. On-Line Microfluidic Extraction using Molecularly Imprinted Polymers for Analysis of Urinary Tobacco Specific Nitrosamines – a Potential Tool to Assess Cancer Risks. Presented at the 2009 AAPS Graduate Student Symposium in Analysis and Pharmaceutical Quality in Los Angeles, CA, November 2009. Halquist Curriculum Vitae Page 6 of 6.
  18. Shah K. A., Peoples, M. C., Halquist, M. S., James, J. R. and Karnes, H. T. Online Coupling of Molecularly Imprinted Polymeric Micro-column with Tandem MS for Analysis of a Urinary Tobacco Specific Nitrosamine by Direct Injection. 15th Annual Meeting of the Society for Research on Nicotine and Tobacco. Dublin, Ireland, April, 2009
  19. Kumar Shah, Michael C. Peoples, Matthew S. Halquist and H. Thomas Karnes. Investigation in the Analysis of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol (NNAL) in Urine by Direct Injection on a Molecularly Imprinted Polymeric (MIP) Micro-column coupled on-line with Tandem MS. Presented at the School of Pharmacy Research Day, Virginia Commonwealth University, 2008.
  20. James JR, Shah KA, Halquist MS, Karnes HT: LC/MS-MS Method for Determination of Tobacco Specific Nitrosamines (TSNA) Metabolite NNAL in Human Urine. Presented at the Society for Research on Nicotine and Tobacco, Portland, Oregon, March 2008.
  21. Omnia A. Ismaiel, Matt. S. Halquist, Abdella Shallaby, Magda Y. El-Mammli, and H. Thomas. Karnes (2007). Monitoring Phospholipids for Assessment of Matrix Effects in a LC/MS/MS Method for Chlorpheniramine in Human Plasma using ESI and APCI. Poster presented at the 2007 AAPS Annual Meeting & Exposition.
  22. Kumar A. Shah, Matt S. Halquist and H. Thomas Karnes (2006). Preliminary investigation in the analysis of tobacco specific nitrosamines using molecularly imprinted polymers - a potential tool to evaluate cancer risk. Poster presented at the Daniel T. Watts Research Poster Symposium, A Scientific Forum for the VCU Community, Virginia Commonwealth University.
  23. Omnia A. Ismaiel, Matt. S. Halquist and H. Thomas. Karnes (2006). Monitoring phospholipids for analysis of matrix effects in a liquid chromatography-tandem mass spectrometry method for determination of hydrocodone and pseudoephedirne in human plasma. Poster presented at the Daniel T. Watts Research Poster Symposium, A Scientific Forum for the VCU Community, Virginia Commonwealth University.

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Last updated: 2015-7-8