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Biography

Prof. Donghoon Yoon

University of Utah, USA

Email: dong.yoon@hsc.utah.edu

 

Qualifications


2004 Ph.D., University of Texas MD Anderson Cancer Center, Department of Immunology

1997 M.A., Auburn University, Department of Animal and Dairy Sciences

1990 B.Sc., Sung Kyun Kwan University, Department of Genetic Engineering

Publications(Selected)

  1. Yoon D, Song J, Kim H, Kim B, Kim S, Arnold G, Elliot S, and Prchal JT, “Tissue-Specific HIF-1 and HIF-2 Regulatory Elements and Their Roles in Erythropoietin Gene Expression”, In Preparation
  2. Yoon D, Song J, Bruchova H, Divoky V and JT Prchal, “Gain-of-function Human Erythropoietin Receptor Causes a Prolonged Primitive Erythropoiesis”, Submitted to Haematologicae
  3. Yoon D*, Song J*, Thiagarajan P, and Prchal JT, "Neocytolysis is caused by increase of mitochondria derived ROS and impaired ROS protection," *Both authors contributed equally to this work, Manuscript ready to submit to Nature
  4. Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva AI, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Song J, Simon MC, Huang J, Yoon D, McClain D, Prchal JT, and VR Gordeuk, “Decreased serum glucose and glycosylated hemoglobin levels in patients with chuvash polycythemia: a role for HIF in glucose metabolism,” Reviewed by Journal of Molecular Medicine and Under Revision
  5. Ljubas N, Piterkova L, Huff C, Bilic E, Yoon D, Gordeuk VR, and Prchal JT, "Polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation has a different phenotype than Chuvash polycythemia (VHL 598CT:R200W)," Revised version is under review in Hematologicae
  6. Swierczek S, Yoon D, Bellanné-Chantelot C, Kim SJ, St. Martin C, Delhommeau F, Najman A, and Prchal JT, "Extent of hematopoietic involvement by TET2 mutations in JAK2V617F polycythemia vera," 2011, Haematologica, Epub Ahead, DOI: 10.3324/haematol.2010.029678, PMID: 21273266
  7. Lee H, Maeng K, Dang H, Kang K, Jung JH, Kang H, Prchal JT, Yoo E, and D Yoon, 2011, "Methyl dehydro-jasmonate has anti-inflammatory effect cells and its molecular targets miR-155 and NF-κB pathway against LPS stimulation on RAW264.7." Journal of Molecular Medicine, 89:83-90, DOI: 10.1007/s00109-010-0688-0, PMID: 20953575
  8. Perrotta S, Cucciolla V, Ferraro M, Ronzoni L, Tramontano A, Rossi F, Scudieri AC, Borriello A, Roberti D, Nobili B, Cappellini MD, Oliva A, Amendola G, Migliaccio AR, Mancuso P, Martin-Padura I, Bertolini F, Yoon D, Prchal JT, and Ragione FD, 2010, "EPO receptor gain-of-function causes hereditary polycythemia, alters CD34+ cell differentiation and increases circulating endothelial precursors," Plos One, 5(8), doi:10.1371/journal.pone.0012015, PMID: 20700488
  9. Yoon D*, Okhotin D*, Okhotin J, Okhotin D, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, and VR Gordeuk, 2010, “Increased Sizes of Liver, Spleen, Kidneys in Chuvash Polycythemia Associated with Up-regulation of HIF-2α.” Journal of Molecular Medicine, 88(5), 523-530. *Both authors contributed equally to this work. This work was evaluated by Faculty of 1000 Biology: http://f1000biology.com/article/id/ 1995960 /evaluation
  10. Bruchova H, Yoon D, and JT Prchal, 2010, “MiR-451 Enhances Erythroid Differentiation in K562 cells”, Leukemia and Lymphoma, Apr; 51(4):686-93
  11. Hegde S, Ni S, He S, Yoon D, Feng GS, Watowich SS, Paulson RF, and PA Hankey, 2009, "Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation", Oncogene, 28, 3349-3359
  12. Kim Y, Song J, Mays C, Titlow W, Yoon D and C Ryou, 2009, “Changes in Gene Expression of Kringle Domain-Containing Proteins in Murine Brains and Neuroblastoma Cells infected by Prions”, Molecular and Cellular Biochemistry, 328(1-2):177-82
  13. Yoon D*, Bruchova H*, Agarwal AM, Swierczeck S and JT Prchal, 2009, "Erythropoiesis in Polycythemia Vera Is Hyper-proliferative and Has Accelerated Differentiation; Potential Roles of MicroRNAs and Their Target Genes for Polycythemia Vera Pathogenesis”, Blood Cells, Molecules, Diseases, 43, 81-87, *Both authors contributed equally to this work.
  14. Yoon D, Agarwal N and Prchal JT, 2008, "Does Erythropoietin Promote Tumor Growth?", Clinical Cancer Research, 14; 1920
  15. Yoon D, Kim BJ, and JT Prchal, 2008, “Hematopoietic specific GATA-1-improved Cre Mouse for Erythroid-Specific Gene Modification”, Blood Cells, Molecules, Diseases, Vol 40(3) 381-387
  16. Domenico ID, Vaughn MB, Yoon D, Kushner JP, Ward DM and J Kaplan, 2007, “Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations”, Blood, Nov;110 3780-3783
  17. Bruchova H, Yoon D, Agarwal AM, Mendell J, JT Prchal, 2007, “The Regulated Expression of miRNAs in Normal and Polycythemia Vera Erythropoiesis”, Journal of Experimental Hematology, 35(11): p. 1657-1667
  18. Gaikwad A*, Verstovsek S*, Yoon D, Chang KT, Manshouri T, Nussenzveig R, Cortes J, Vainchenker W, and JT Prchal, 2007, “Imatinib Effect on Growth and Signal Transduction in Polycythemia Vera”, Journal of Experimental Hematology, Jun;35(6):931-8.
  19. Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A and JT Prchal, 2006, “HIF-1α-deficiency results in dysregulated erythropoietin signaling and iron homeostasis in mouse development”, Journal of Biological Chemistry, 281(35):25703-25711
  20. Mnjoyan Z, Yoon D, Li J, Delhommeau F, and V Afshar-Kharghan, 2006, “JAK2 Mutation Increases PRV-1 Expression”, Haematologica, 91:411-412
  21. Yoon D and SS Watowich, 2003, "Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway", Journal of Experimental Hematology, 31; 1310-1316.