Dr. Massimo Donadelli

Prof. Massimo Donadelli

University of Verona, Italy



2001 Ph.D., University of Verona

Publications (selected)

  1. Cecconi D, Scarpa A, Donadelli M, Palmieri M, Hamdan M, Aster H, Righetti PG.Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin A. Electrophoresis. 2003 Jun; 24 (11): 1871-8.
  2. Donadelli M, Costanzo C, Faggioli L, Scupoli MT, Moore PS, Bassi C, Scarpa A, Palmieri M. Trichostatin A, an inhibitor of histone deacetylases, strongly supresses growth of pancreatic adenocarcinoma cells. Mol. Carcinog. 2003 Oct; 38 (2): 59-69.
  3. Cecconi D*, Astner H*, Donadelli M*, Palmieri M, Missiaglia E, Scarpa A, Hamdan M, Righetti PG. Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2’-deoxycytidine. Electrophoresis. 2003 Dec;24(24):4291-303. * authors contributed equally to this work and share the first authorship.
  4. Faggioli L, Costanzo C, Donadelli M, Palmieri M. Activation of the interleukin-6 promoter by a dominant negative mutant of c-jun. Biochim Biophys Acta. 2004 May 28;1692(1):17-24.
  5. Moore PS, Barbi S, Donadelli M, Costanzo C, Bassi C, Palmieri M, Scarpa A. Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. Biochim Biophys Acta. 2004 Sep 17;1693(3):167-76
  6. Missiaglia E, Donadelli M, Palmieri M, Crnogorac-Jurcevic T, Scarpa A and Lemoine NR. Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2’-deoxycytidine treatment is associated with activation of the interferon signalling pathway. Oncogene. 2005 Jan 6;24(1):199-211.
  7. D Cecconi*, M Donadelli*, A Scarpa, A Milli, M Palmieri, M Hamdan, LB Areces, J Rappsilber, and PG Righetti. Proteomic Analysis of Pancreatic Ductal Carcinoma Cells after Combined Treatment with Gemcitabine and Trichostatin A. J Proteome Res. 2005 Nov-Dec;4(6):1909-16. * authors contributed equally to this work and share the first authorship.
  8. Piacentini P*, Donadelli M*, Costanzo C, Moore PS, Palmieri M and Scarpa A. Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. Virchows Arch. 2006 Mar 28. * authors contributed equally to this work and share the first authorship.
  9. Donadelli M, Dalla Pozza E, Costanzo C, Scupoli MT, Piacentini P,Scarpa A and Palmieri M. Increased stability of p21WAF1/CIP1 mRNA is required for ros/erk-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate. Biochim Biophys Acta. 2006. Sep;1763(9):917-26.
  10. Gotte G, Donadelli M, Laurents DV, Vottariello F, Morbio M, Libonati M. Increase of RNase a N-terminus polarity or C-terminus apolarity changes the two domains' propensity to swap and form the two dimeric conformers of the protein. Biochemistry. 2006 Sep 12;45(36):10795-806.
  11. Cecconi D*, Donadelli M*, Rinalducci S, Zolla L, Scupoli MT, Scarpa A, Palmieri M, Righetti PG. Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. Proteomics. 2007 May;7(10): 1644-53.
  12. Donadelli M, Costanzo C, Beghelli S, Scupoli MT, Dandrea M, Bonora A, Piacentini P, Budillon A, Caraglia M, Scarpa A, Palmieri M. Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. Biochim Biophys Acta. 2007 Jul;1773(7):1095-106.
  13. Pouckova P, Morbio M, Vottariello F, Laurents DV, Matousek J, Soucek J, Gotte G, Donadelli M, Costanzo C, Libonati M. Cytotoxicity of Polyspermine-Ribonuclease A and Polyspermine-Dimeric Ribonuclease A. Bioconjug Chem. 2007 Nov-Dec;18(6): 1946-55.
  14. Donadelli M, Dalla Pozza E, Costanzo C, Scupoli MT, Scarpa A, Palmieri M. Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes. J Cell Biochem. 2008 May 1;104(1):202-12.
  15. Scupoli MT, Donadelli M, Cioffi F, Rossi M, Perbellini O, Malpeli G, Corbioli S, Vinante F, Krampera M, Palmieri M, Scarpa A, Ariola C, Foà R, Pizzolo G.Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways. Haematologica. 2008 Apr;93(4):524-32.
  16. Gaviraghi M, Caricasole A, Costanzo C, Diamanti D, Dandrea M, Donadelli M, Scarpa A, Palmieri M. Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene.BMC Mol Biol. 2008 Jun 12;9:56.
  17. Donadelli M, Dalla Pozza E, Scupoli MT, Costanzo C, Scarpa A, Palmieri M.Intracellular zinc increase inhibits p53(-/-) pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis. Biochim Biophys Acta. 2009 Feb;1793 (2):273-80.
  18. Cecconi D*, Donadelli M*, Dalla Pozza E, Rinalducci S, Zolla L, Scupoli MT, Righetti PG, Scarpa A, Palmieri M. Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. Proteomics. 2009 Apr;9 (7):1952-66.* authors contributed equally to this work and share the first authorship.
  19. Dandrea M, Donadelli M, Costanzo C, Scarpa A, Palmieri M.MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. Nucleic Acids Res. 2009 Nov;37(20):6681-90.
  20. Cecconi D, Palmieri M, Donadelli M. Proteomics in pancreatic cancer research. Review Proteomics. 2011 Feb;11(4):816-28.
  21. Dalla Pozza E, Donadelli M, Costanzo C, Zaniboni T, Dando I, Franchini M, Arpicco S, Scarpa A, Palmieri M. Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives.Free Radic Biol Med. 2011 Apr 15;50(8):926-33.
  22. Donadelli M, Dando I, Zaniboni T, Costanzo C, Dalla Pozza E, Scupoli MT, Scarpa A, Zappavigna S, Marra M, Abbruzzese A, Bifulco M, Caraglia M, Palmieri M. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis. 2011 Apr 28;2:e152.
  23. Dalla Pozza E, Fiorini C, Dando I, Menegazzi M, Sgarbossa A, Costanzo C, Palmieri M, Donadelli M. Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine.Biochim Biophys Acta. 2012 Jun 15. In press.
  24. A Rosati, S Bersani, F Tavano, E Dalla Pozza, M De Marco, M Palmieri, V De Laurenzi, R Franco, G Scognamiglio, R Palaia, A Fontana, P di Sebastiano, M Donadelli, I Dando, JP Medema, F Dijk, LWelling, FF di Mola, R Pezzilli, MC Turco, A Scarpa. Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival. American Journal of Pathology. Accepted.