Prof. Carlos A. Jerez

Prof. Carlos A. Jerez

University of Chile, Chile






1973 Ph.D., University of Iowa, USA

1968 B.Sc., University of Chile, Chile


Publications (Selected)

  1. Delgado, M., Toledo, H. and Jerez, C.A. (1998) Molecular cloning, sequencing and expression of a chemoreceptor gene from Leptospirillum ferrooxidans. Appl. Environ. Microbiol. 64: 2380-2385.
  2. Varela, P., Levicán, G. and Jerez, C.A. (1998) An immunological strategy to monitor in situ the phosphate-starvation state in Thiobacillus ferrooxidans. Appl. Environ. Microbiol. 64: 4990-4993.
  3. Guiliani, N. and Jerez, C.A. (2000) Molecular cloning, sequencing and expression of Omp40, the gene coding for the major outer membrane protein from the acidophilic Thiobacillus ferrooxidans. Appl.Environ. Microbiol. 66: 2318-2324.
  4. Jerez, C.A. (2001) Chemotactic transduction in biomining microorganisms. Hydrometallurgy. 59: 347-356.
  5. Cardona, S., Remonsellez, F., Guiliani, N. and Jerez, C.A. (2001) The alleged glycogen-bound polyphosphate kinase from Sulfolobus acidocaldarius is actually a glycogen synthase. Appl. Environ. Microbiol. 67: 4733-4780.
  6. Toledo, H., Valenzuela, M., Rivas, A. and Jerez, C.A. (2002). Acid stress response in Helicobacter pylori. FEMS Microbiol. Lett. 213:67-72.
  7. Ramírez, P., Toledo, H., Guiliani, N. and Jerez, C.A. (2002) An exported rhodanese-like protein is induced during growth of Acidithiobacillus ferrooxidans in metal sulfides and different sulfur compounds. Appl. Environ. Microbiol. 68:1837-1845.
  8. Cardona, S. T., Chávez, F. P. and Jerez, C.A. (2002) The exopolyphosphatase gene from Sulfolobus solfataricus: characterization of the first gene found to be involved in polyphosphate metabolism in Archaea. Appl. Environ. Microbiol. 68:4812-4819.
  9. Vera, M., Guiliani, N. and Jerez, C.A. (2003) Proteomic and genomic analysis of the phosphate starvation response of Acidithiobacillus ferrooxidans. Hydrometallurgy. 71: 125-132.
  10. Chávez, F., Lünsdorf, H. and Jerez, C.A. (2004) Growth of polychlorinated biphenyl (PCB)-degrading bacteria in the presence of biphenyl and chlorobiphenyls generates oxidative stress and massive accumulation of inorganic polyphosphate. Appl. Environ. Microbiol. 70:3064-3072.
  11. Ramírez., P., Guiliani, N., Valenzuela, L., Beard, S., and Jerez, C.A. (2004) Differential protein expression during growth of Acidithiobacillus ferrooxidans on ferrous iron, sulfur compounds or metal sulfides. Appl. Environ. Microbiol. 70: 4491-4498.
  12. Alvarez, S. and Jerez, C.A. (2004) Copper ions stimulate polyphosphate degradation and phosphate efflux in Acidithiobacillus ferrooxidans. Appl. Environ. Microbiol. 70: 5177-5182.
  13. Acosta, M., Beard, S., Ponce, J., Vera, M., Mobarec, J.C. and Jerez, C.A. (2005) Identification of putative sulfurtransferase genes in the extremophilic Acidithiobacillus ferrooxidans ATCC 23270 genome: structural and functional characterization of the proteins. OMICS. 9: 13-29.
  14. Farah, C., Vera, M., Morin, D., Haras, D., Jerez, C.A. and Guiliani, N. (2005) Evidence of a functional quorum sensing type AI-1 system in the extremophilic bacterium Acidithiobacillus ferrooxidans. Appl. Environ. Microbiol.  71: 7033-7040.
  15. Valenzuela, L., Chi, A., Beard, S., Orell, A., Guiliani, N., Shabanowitz, J., Hunt, D.F. and Jerez, C.A. (2006) Genomics, metagenomics and proteomics in biomining microorganisms. Biotechnol. Adv. 24: 197-211.
  16. Chávez, F.P., Gordillo, F. and Jerez, C.A. (2006) Adaptive responses and cellular behaviour of biphenyl-degrading bacteria toward polychlorinated biphenyls. Biotechnol. Adv. 24: 309-320.
  17. Remonsellez, F., Orell, A. and Jerez, C.A. (2006) Copper tolerance of the thermoacidophilic archaeon Sulfolobus metallicus: possible role of polyphosphate metabolism. Microbiology 152: 59-66.
  18. Gordillo, F., Chavez, F.P. and Jerez C.A. (2007) Motility and chemotaxis of Pseudomonas sp. B4 towards polychlorobiphenyls and chlorobenzoates. FEMS Microbiol. Ecol. 60: 322-328.
  19. Jerez, C.A. (2007) Biomining in the post-genomic age: advances and perspectives. Adv. Mat. Res. 20-21: 389-400.
  20. Chi, A., Valenzuela, L., Beard, S., Mackey, A.J. , Shabanowitz, J., Hunt, D.F. and Jerez, C.A. (2007) Periplasmic proteins of the extremophile Acidithiobacillus ferrooxidans: a high throughput proteomic analysis. Mol. Cell. Proteomics. 6: 2239-2251.
  21. Soulère L., Guiliani N., Queneau Y., Jerez C.A., Doutheau A. (2008) Molecular insights into quorum sensing in Acidithiobacillus ferrooxidans bacteria via molecular modelling of the transcriptional regulator AfeR and of the binding mode of long-chain acyl homoserine lactones. J. Mol. Model. 14:599-606.
  22. Frezza M, Soulère L, Reverchon S, Guiliani N, Jerez C, Queneau Y, Doutheau A. (2008) Synthetic homoserine lactone-derived sulfonylureas as inhibitors of Vibrio fischeri quorum sensing regulator. Bioorg. Med. Chem.16:3550-3556.
  23. Ruiz, L.M., Valenzuela S., Castro M., Gonzalez A., Frezza M., Soulère L., Rohwerder T., Queneau Y.,  Doutheau A., Sand W.,  Jerez, C.A. and Guiliani, N. (2008) AHL communication is a widespread phenomenon in biomining bacteria and seems to be involved in mineral-adhesion efficiency. Hydrometallurgy. 94:133-137.
  24. Vera, M., Pagliai, F., Guiliani, N., and Jerez, C.A. (2008) The chemolithoautotroph Acidithiobacillus ferrooxidans can survive under phosphate limiting conditions by the expression of a C-P lyase operon that allows it to grow in phosphonates. Appl. Environ. Microbiol. 74:1829-1835.
  25. Jerez, C.A. (2008) The use of genomics, proteomics and other OMICS technologies for the global understanding of biomining microorganisms. Hydrometallurgy. 94: 162-169.
  26. Chavez, F.P., Mauriaca, C., and Jerez, C.A. (2009) Constitutive and regulated expression vectors to construct polyphosphate deficient bacteria. BMC Research Notes. 2: 50.
  27. Navarro, C.A., Orellana, L.H., Mauriaca, C., and Jerez, C.A. (2009) Transcriptional and functional studies of Acidithiobacillus ferrooxidans genes related to survival in the presence of copper. Appl. Environ. Microbiol. 75:6102-6109.
  28. Varela C., Mauriaca C., Paradela A., Albar J.P., Jerez C.A, and Chávez F.P. (2010). New structural and fuctional defects in polyphosphate deficient bacteria: A cellular and proteomic study. BMC Microbiol. 10: 7.
  29. Orell, A., Navarro, C.A., Arancibia, R., Mobarec, J.C., and Jerez, C.A. (2010) Life in blue: Copper resistance mechanisms of bacteria and Archaea used in industrial biomining of minerals. Biotechnol. Adv. 28: 839- 848.
  30. Beard, S., Paradela, A., Albar,  J.P., and Jerez C.A. Growth of Acidithiobacillus ferrooxidans ATCC 23270 in thiosulfate under oxygen-limiting conditions generate extracellular sulfur globules by means of a secreted tetrathionate hydrolase. Front. Microbio. 2:79. doi: 10.3389/fmicb.2011.00079.
  31. Chavez, F.P., Lagos, C.A., Reyes-Parada, M., Guiliani, N. and Jerez, C.A. (2011) Polyphosphate synthesis as a target for novel antibiotics. Current Enzyme Inhibition 7, 163-168.
  32. Ruiz, L.M., Castro, M., Barriga, A., Jerez, C.A., and Guiliani, N. (2011) The extremophile  Acidithiobacillus ferrooxidans  possesses a c-di-GMP signaling pathway that could play a significant role during bioleaching of minerals. Lett. Appl. Microbiol. 54:133-139.
  33. Orellana, L.H., and Jerez, C.A. (2011) A genomic island provides Acidithiobacillus ferrooxidans ATCC 53993 additional copper resistance: a possible competitive advantage. Appl. Microbiol. Biotechnol. 92:761-767.
  34. Orell, A., Navarro, C.A., Rivero, M., Aguilar, J.S., and Jerez, C.A. (2012) Inorganic polyphosphates in extremophiles and their posible functions. Extremophiles. DOI.1007/s00792-012-0457-9.
  35. Orell, A., Remonsellez, F., Arancibia R., and Jerez, C.A. (2013) Molecular characterization of copper and cadmium resistance determinants in the biomining thermoacidophilic archaeon Sulfolobus metallicus. Archaea. Volume 2013, Article ID 289236, DOI: 10.1155/2013/289236, 16 pages.
  36. Jerez, C.A. (2013) The use of extremophilic microorganisms in industrial recovery of metals. In Extremophiles: Sustainable Resources and Biotechnological Implications. Pp. 319-334. In Songh, O., ed. John Wiley & Sons, Inc.
  37. Navarro, C.A., von Bernath, D. and Jerez, C.A. (2013) Heavy metal resistance strategies of acidophilic bacteria and their acquisition: importance for biomining and bioremediation. Biol. Res. 46: 363-371.
  38. Almarcegui, R.J., Navarro, C.A., Paradela, A., Albar, J.P., von Bernath, D. and Jerez, C.A. (2014) New copper resistance determinants in the extremophile Acidithiobacillus ferrooxidans: a quantitative proteomic analysis. J. Proteome Res. 13: 946-960.
  39. Almarcegui, R.J., Navarro, C.A., Paradela, A., Albar, J.P., von Bernath, D. and Jerez, C.A. (2014) Response to copper of Acidithiobacillus ferrooxidans ATCC 23270grown in elemental sulfur. Res Microbiol. 165: 761-772.