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Biography

Prof. Alice Santos-Silva

Faculty of Pharmacy
Porto University, Portugal


Email: assilva@ff.up.pt


Qualifications

1995  Ph.D., Pharmacy (Biochemistry and Hematology), Faculty of Pharmacy, Porto University, Portugal
1985  Professor of Hematology, Faculty of Pharmacy, Porto University, Portugal
1982  Pharmacy Degree, Faculty of Pharmacy, University of Coimbra, Portugal


Publications(Selected)

  1. Rocha S, Vitorino RMP, Lemos-Amado FM, Castro E, Rocha-Pereira P, Barbot J, Cleto E, Ferreira F, Quintanilha A, Belo L, Santos-Silva A. Presence of cytosolic peroxiredoxin 2 in the erythrocyte membrane of patients with Hereditary Spherocytosis. Blood Cells Mol and Dis, 2008,41:5-9.
  2. Costa E, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Altered erythrocyte membrane protein composition in chronic kidney disease stage 5 patients under haemodialysis and recombinant human erythropoietin therapy. Blood Purification, 2008,26(3):267-73.
  3. Costa E, Rocha-Pereira P, Rocha S, Reis F, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Role of prohepcidin, inflammatory markers and iron status in resistance to rhEPO therapy in hemodialysis patients. Am J Nephrol, 2008, 28(4):677-83.
  4. Costa E, Lima M, Alves JM, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Inflammation, T-cell phenotype, and inflammatory cytokines in chronic kidney disease patients under hemodialysis and its relationship to resistance to recombinant human erythropoietin therapy. J Clin Immunol, 2008,28(3):268-75.
  5. Costa E, Lima M, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Faria MD, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. IL-7 serum levels and lymphopenia in hemodialysis patients, non-responders to recombinant human erythropoietin therapy. Blood Cells and Mol Dis, 2008,41(1):134-35.
  6. Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. Fetal lipoprotein changes in preeclampsia. Acta Obstet et Gynecol Scandinavica, 2008,87(6):628-34.
  7. Costa E, Rocha S, Rocha-Pereira P, Reis F, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. DMT1 (NRAMP2/DCT1) genetic variability and resistance to rhEPO therapy in chronic kidney disease patients under haemodialysis. Acta Haematologica, 2008,120(1):11-13.
  8. Costa E, Rocha S, Rocha-Pereira P, Nascimento H, Castro E, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Neutrophil activation and resistance to recombinant human erythropoietin therapy in hemodialysis patients Am J Nephrol, 2008, 28(6):935-40.
  9. Belo L, Santos-Silva A, Quintanilha A, Rebelo I. Similarities between pre-eclampsia and atherosclerosis: a protective effect of physical exercise?. Current Med Chem, 2008, 15(22):2223-29.
  10. Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. Relationship between maternal and fetal hemostatic disturbances in preeclamptic pregnancies. Thromb Research, 2008, 123:219-24.
  11. Costa E, Rocha S, Rocha-Pereira, Flávio Reis P, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in Chronic Kidney Disease Patients under haemodialysis and recombinant human erythropoietin therapy. J Vascular Access, 2008, 9(4):248-53.
  12. Catarino C, Rebelo I, Belo L, Rocha-Pereira P, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. Erythrocyte changes in Preeclampsia: relationship between maternal and fetal erythrocyte damage. J Perinatal Med, 2009, 37:19-27.
  13. Costa E, Rocha S, Rocha-Pereira P, Reis F, Castro E, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Effect of hemodialysis procedure in prohepcidin serum levels in regular hemodialysis patients. Clin Nephrol, 2009, 71(2):233-35.
  14. Nascimento H, Silva L, Lourenço P, Vieira E, dos Santos R, Rego C, Ferreira Mansilha H, Santos-Silva A, Belo L. Lipoprotein (a) levels in obese Portuguese children and adolescents: contribution of the pentanucleotide repeat (TTTTA)n polymorphism in the apolipoprotein(a) gene. Arch Ped & Adolescent Med, 2009, 163(4):393-94.
  15. Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the disease. J Dermatol Sci, 2009, 55(3):202-4.
  16. Rocha S, Costa E, Coimbra S, Nascimento H, Catarino C, Rocha-Pereira P, Quintanilha A, Belo L, Santos-Silva A. Linkage of cytosolic peroxiredoxin 2 to erythrocyte membrane imposed by hydrogen peroxide induced oxidative stress. Blood Cells and Mol Dis, 2009, 43(1):68-73.
  17. Garrido P, Reis F, Costa E, Teixeira-Lemos E, Parada B, Alves R, Piloto N, Sereno J, Figueiredo A, Pinto R, Carvalho L, Rocha-Pereira P, Belo L, Santos-Silva A, Teixeira F. Characterization of a rat model of moderate chronic renal failure-focus on hematological,biochemical,andcardiorenalprofile. Renal Failure,2009,31(9):833-42.
  18. Costa E, Swinkles DW, Laarakkers CM, Rocha-Pereira P, Rocha S, Reis F, Teixeira F, Miranda V, Faria MS, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in hemodialysis patients Acta Haematologica, 2009, 122(4):226-29.
  19. Catarino C, Rebelo I, Belo L, Rocha S, Castro E, Patrício B, Quintanilha A, Santos-Silva A. Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy. Growth Factors, 2009, 27(6):345-51.
  20. Nascimento H, Silva L, Lourenço P, Weinfurterová R, Castro E, Rego C, Ferreira H, Guerra A, Quintanilha A, Belo L, Santos-Silva A. Lipid profile in portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels. Arch Ped & Adolescent Med, 2009, 163(11):1030-36.
  21. Costa E, Belo L, Quintanilha A, Santos-Silva A. Resistance to recombinant human erythropoietin therapy in haemodialysis patients-focus on inflammatory cytokines, leukocyte activation, iron status and erythrocyte damage. J Nephrol Renal Transplant, 2009, 2(3):66-83.
  22. Rocha S, Costa E, Ferreira F, Cleto E, Barbot J, Rocha-Pereira P, Quintanilha A, Belo L, Santos-Silva A. Hereditary Spherocytosis and the (TA)nTAA polymorphism of UGT1A1 gene promoter region – a comparison of the bilirubin plasmatic levels in the different clinical forms. Blood Cells and Mol Dis, 2010, 44:117-19.
  23. Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. C–reactive protein and leukocyte activation in psoriasis vulgaris according to severity and therapy. J Eur Acad Dermatol and Venereol, 2010, 24(7):789-96.
  24. Rocha S, Costa E, Rocha-Pereira P, Ferreira F, Cleto E, Barbot J, Quintanilha A, Belo L, Santos-Silva A. Erythrocyte membrane protein destabilization versus clinical outcome in 160 Portuguese Hereditary Spherocytosis patients. Br J Hematol, 2010, 149(5):785-94.
  25. Nascimento H, Rocha S, Rego C, Mansilha HF, Quintanilha A, Santos-Silva A, Belo L. Leukocyte count versus C-reactive protein levels in obese Portuguese patients aged 6-12 years old. The Open Biochem J, 2010, 10(4):72-76.
  26. Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. Circulating adipokine levels in Portuguese patients with psoriasis vulgaris according to BMI, severity and therapy. J Eur Acad Dermatol and Venereol, 2010; 24(12):1386-94.
  27. Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. Psoriasis therapy and cardiovascular risk factors: a 12-week follow-up study. Am J Clin Dermatol, 2010; 11(6):423-32.
  28. Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy. Br J Dermatol, 2010; 163(6):1282-90.
  29. Rocha S, Costa E, Rocha-Pereira P, Ferreira F, Cleto E, Barbot J, Quintanilha A, Belo L, Santos-Silva A. Complementary markers for the clinical severity classification of hereditary spherocytosis in unsplenectomized patients”. Blood Cells Mol Dis, 2011, 46(2):166-70.
  30. Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P, Santos-Silva A. Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: A cross-sectional and longitudinal study. Am J Clin Dermatol. 2012, 13(1),37-47.
  31. Coimbra S, Figueiredo A, Castro E, Rocha-Pereira P, Santos-Silva A. The roles of cells and cytokines in the pathogenesis of psoriasis. Int J Dermatol, 2011, In Press.
  32. Rocha S, Rocha-Pereira P, Ferreira F, Cleto E, Barbot J, Quintanilha A, Belo L, Santos-Silva A. Erythropoiesis versus inflammation in Hereditary Spherocytosis clinical outcome. Clin Biochem, 2011, 44(13):1137-43.
  33. Nascimento H, Costa E, Rocha-Pereira P, Rego C, Ferreira Mansilha H, Quintanilha A, Santos-Silva A, Belo L. Cardiovascular risk factors in Portuguese obese children and adolescents: impact of small reductions in body mass index imposed by life modification. The Open Biochem J, 2011; In press.