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Biography

Prof. Deepak Bastia

Department of Biochemistry and Molecular Biology

Medical University of South Carolina, USA


Email: bastia@musc.edu


Qualifications

1971 Ph.D., Biology, University of Chicago

1963 B.Sc., Biology, Mathematics and Chemistry, Utkal University


Publications (Selected)

  1. Gautam, A. and Bastia, D. 2001. A replication terminus located at or near a replication checkpoint of Bacillus subtilis functions independently of stringent control. J. Biol. Chem. 276:8771-8777.
  2. Mohanty, B.K., Bussiere, D.E., Sahoo, T., Pai, K.S., Meijer, W.J., Bron, S. and Bastia, D. 2001. Structural and functional analysis of a bipolar replication terminus. Implications for the origin of polarity of fork arrest. J. Biol. Chem. 276:13160-13168.
  3. Guatam, A., Mulugu, S., Alexander, K. and Bastia, D. 2001. A single domain of the replication termination protein of Bacillus subtilis is involved in arresting both DnaB helicase and RNA polymerase. J. Biol. Chem. 276:23471-23479.
  4. Mulugu, S., Potnis, A., Shamsuzzaman, Taylor, J., Alexander, K. and Bastia, D. 2001. Mechanism of termination of DNA replication of Escherichia coli involves helicase-contrahelicase interaction. Proc. Natl. Acad. Sci. USA 98:9569-9574.
  5. Sharma, R., Kachroo, A. and Bastia, D. 2001. Mechanistic aspects of DnaA-RepA interaction as revealed by yeast forward and reverse two-hybrid analysis. EMBO J. 20:4577-4587.
  6. Abhyankar, M. M, Reddy, J. M., Sharma, R., Bullesbach, E. and Bastia, D. (2004) Biochemical investigations of control of replication initiation of plasmid R6K. J. Biol. Chem. 279: 6711-6719.
  7. Zzaman, S., Abhyankar, M. M. and Bastia, D. (2004) Reconstitution of F factor replication in vitro with purified proteins. J. Biol. Chem. 279: 17404-17410.
  8. Mohanty, B. K. and Bastia, D. (2004) Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest. J. Biol. Chem. 279: 1932-1941.
  9. Zzaman, S., Reddy, J. M. and Bastia, D. (2004) The DnaK-DnaJ-GrpE chaperone system activates inert wild type Pi initiator protein of R6K into a form active in replication. J. Biol. Chem. 279, 50886-50894.
  10. Zzaman, S. and Bastia, D. (2005) Oligomeric Initiator protein-mediated DNA looping negatively regulates plasmid replication in vitro by preventing origin melting Mol. Cell 20, 833-843.
  11. Bastia, D. (2005) Mechanism of initiation and termination of plasmid DNA replication in prokaryotes. Curr. Sci. 89: 329-334
  12. Bastia, D. and Mohanty, B. K. (2006). Termination of DNA Replication, In DNA replication and human disease (ed. M.L. DePamphilis), pp. 155-174. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
  13. Krings, G. and Bastia, D. (2005) Sap1p binds to Ter1 at the ribosomal DNA of Schizosaccharomyces pombeand causes polar replication fork arrest. J. Biol. Chem. 280:39135-39142.
  14. Mohanty, B. K., Bairwa, N. and Bastia, D. (2006) The Tof1p-Csm3p protein complex counteracts the Rrm3p hellicase to control replication termination of Saccharomyces cerevisiae. Proc. Nat. Acad. SciUSA103, 897-902.
  15. Swan, M., Bastia, D. and Davies, C. (2006) Crystalstructure of the Pi-iteron complex of plasmid R6K: Implications for initiation of replication Proc. Natl. Acad. Sci. USA 103: 18481- 18486.
  16. Krings, G. and Bastia, D.(2006) Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex. Mol. Cell. Biol. 26, 8061-8074.
  17. Bastia, D., Zzaman, S., Krings, G., Saxena, M, Peng, X. and Greenberg, M.M. (2008) Mechanism of replication termination as revealed by Tus-mediated polar arrest of a sliding helicase. Proc. Natl. Acad. SciUSA105, 12831-12836.
  18. Biswas, S. and Bastia, D. (2008) Mechanistic insights into termination of DNA replication obtained from Reb1p-Ter3 interaction inS. pombe. Mol. Cell. Biol. 28: 6844-6857.
  19. Mohanty, B.K., Bairwa, N. K. and Bastia, D. (2009) Contrasting roles of checkpoint proteins as recombination modulators at Fob1-Ter complexes with or without fork arrest. Eucaryot. Cell 8: 487-495.
  20. Kaplan, D. and Bastia, D. (2009) Mechanism of polar arrest of replication forks. Mol. Microbiol. 72; 279-285.
  21. Saxena, M., Singh, S., Zzaman, S. and Bastia, D. (2010) Investigations of Pi initiator protein-mediated interactions between Replication origins and of the plasmid R6K. J. Biol. Chem 285: 5695-5694.
  22. Saxena, M., Abhayankar, M., and Bastia, D. (2010) Replication initiation at a distance: determination of the cis and trans-acting elements of replication origin. J. Biol. Chem. 285:5705-5712.
  23. Bairwa, N., Zzaman, S. Mohanty, B.K. and Bastia, D. (2010). Replication fork arrest and rDNA silencing are 2 independent and separable functions of the replication terminator protein Fob1 of S. cerevisiae. J. Biol. Chem. 285: 12612-12619.
  24. Singh, S., Sabatinos, S., Forsburg, S. and Bastia, D. (2010) Regulation of replication termination in Schizosccharomyces pombe by Reb1 protein-mediated action at a distance. Cell 142, 868-878.
  25. Bairwa, N.K., Mohanty, B. K. and Bastia, D. (2011) The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae. J. Biol. Chem. 286: 2445-2554.
  26. Bastia, D. and Singh, S. (2011) Chromosome kissing and modulation of replication termination. BioArchitecture. 1: 24-28.