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Biography
1

Prof. Fahd Al-Mulla

Faculty of Medicine, Department of Pathology

Kuwait University, Kuwait

Professor


Email: fahd@al-mulla.org


Qualifications


1999 Ph.D., University of Glasgow U.K


Publications (Selected)

  1. Yang X, Al-Bustan S, Feng Q, Guo W, Ma Z, Marafie M, Jacob S, Al-Mulla F, Xu S. The influence of admixture and consanguinity on population genetic diversity in Middle East. J Hum Genet. 2014 Sep 25. PMID:25253659
  2. Ali RH, Marafie MJ, Bitar MS, Al-Dousari F, Ismael S, Haider HB, Al-Ali W, Jacob SP, Al-Mulla F. Gender-associated genomic differences in colorectal cancer: clinical insight from feminization of male cancer cells. Int J Mol Sci. 2014 Sep 29;15(10):17344-65.
  3. Ali RH, Al-Safi R, Al-Waheeb S, John B, Al-Ali W, Al-Jassar W, Al-Mulla F, Melnyk N, Huntsman DG, Lee CH. Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait. Hum Pathol. 2014 Sep 4. pii: S0046-8177(14)00356-6.
  4. Fahd Al‐Mulla, Makia Marafie, Tuan Zea Tan, and Jean Paul Thiery. Raf Kinase Inhibitory Protein Role in the Molecular Subtyping of Breast Cancer. Journal of Cellular Biochemistry. 2014 Mar;115(3):488-97.
  5. Al-Awadhi R, Husain S, Chehadeh W, Al-Jassar W, Kapila K, Al-Mulla F. Immunocytochemical detection of raf kinase inhibitor protein and human papillomavirus profiling of normal and abnormal cervical ThinPrep samples. Acta Cytol. 2013;57(3):259-65.
  6. David Matallanas, David Romano, Fahd Al-Mulla, Eric O’Neill, Waleed Al-Ali, Piero Crespo, Brendan Doyle, Owen Sansom, Matthias Drosten, Mariano Barbacid, Walter Kolch. Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras. Molecular Cell. 2011 Volume 44, Issue 6, 893-906.
  7. Fahd Al-Mulla, Milad S. Bitar, Abdulla I. Behbehani, Govindarajulu Varadharaj, James J., Going Genetic Profiling of primary tumours predicts metastatic recurrence in early stage colorectal cancer. Mod Pathol. 2006 May;19(5):648-58.
  8. Fahd Al-Mulla, Suad AlFadhli, Altaf Hasan Al-Hakim, James J. Going, Milad S. Bitar, Metastatic recurrence of early stage colorectal cancer is linked to loss of heterozygosity at chromosomes 4 and 14q. J Clin Pathol. 2006 Jun;59(6):624-30
  9. Fahd Al-Mulla, Suzanne Hagan, Abdulla I. Behbehani, Milad S. Bitar, Shirley S. George, James J. Going, Jorge J. Curto García, Lucy Scott, Nicky Fyfe, Graeme I. Murray and Walter Kolch, Raf Kinase Inhibitor Protein (RKIP) expression in a survival analysis of colorectal cancer. J Clin Oncol. 2006 Dec 20;24(36):5672-9
  10. De Bruyne V, Al-Mulla F, Pot B, Methods for microarray data analysis. Methods Mol Biol. 2007;382:373-91.
  11. Fahd Al-Mulla, Utilization of microarray platforms in clinical practice: an insight on the preparation and amplification of nucleic acids from frozen and fixed tissues. Methods Mol Biol.2007;382:115-36.
  12. Fahd Al-Mulla and Rabaa Al-Tamimi, Uses of microarray platforms in cancer: a correlative study between genomic copy number changes and their expression at mRNA and protein levels.Methods Mol Biol. 2007;382:77-95.
  13. Dallol A, Cooper WN, Al-Mulla F, Agathanggelou A, Maher ER, Latif F., Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities. Cancer Res. 2007 Jan 15;67(2):492-500.
  14. Yokoyama Y, Xin B, Shigeto T, Umemoto M, Kasai-Sakamoto A, Futagami M, Tsuchida S, Al-Mulla F, Mizunuma H, Clofibric acid, a peroxisome proliferator-activated receptor {alpha} ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007 Apr;6(4):1379-86.
  15. Fahd Al-Mulla, Suzanne Hagan, Waleed Al-Ali, Sindhu P. Jacob, Abdulla I. Behbehani, Milad S. Bitar, Ashraf Dallol and Walter Kolch, Raf Kinase inhibitor protein: Mechanism of loss of expression and association with genomic instability. J Clin Pathol. 2008 Apr;61(4):524-9
  16. Kapila K, Kehinde EO, Anim JT, Mojiminiyi OA, Vinsu A, George SS, Al-Maghrebi M, Al-Mulla F, Could nuclear matrix protein 22 (NMP22) play a role with urine cytology in screening for bladder cancer? - Experience at Kuwait University. Cytopathology, Volume 19, Issue 6 (p 369-374).
  17. Kaput J, Cotton RG, Hardman L, Watson M, Al Aqeel AI, Al-Aama JY, Al-Mulla F, et al. Contributors to the Human Variome Project Planning Meeting. Planning the human variome project: the Spain report. Hum Mutat. 2009 Apr; 30(4):496-510.
  18. Mojiminiyi OA, Al Mulla F, Abdella NA. Which obesity index best explains the link between adipokines, coronary heart disease risk and metabolic abnormalities in type 2 diabetes mellitus?  Med Princ Pract. 2009;18(2):123-9.
  19. Fahd Al-Mulla, J. Martin Bland, Deborrah Serratt, Julie Miller, Carol Chu, Graham T. Taylor, Age-dependent penetrance of different germline mutations in BRCA1 gene. J Clin Pathol 2009 Apr; 62(4):350-6
  20. Marafie MJ, Al-Awadi S, Al-Mosawi F, Elshafey A, Al-Ali W, Al-Mulla F. Impact of 226C>T MSH2 gene mutation on cancer phenotypes in two HNPCC-associated highly-consanguineous families from Kuwait: emphasis on premarital genetic testing. Fam Cancer. 2009;8(4):289-98. Epub 2009 Aug 8.
  21. Cotton RG, Al Aqeel AI, Al-Mulla F, Carrera P et al. Capturing all disease-causing mutations for clinical and research use: toward an effortless system for the Human Variome Project. Genet Med. 2009 Dec;11(12):843-9.
  22. Bitar MS, Ayed AK, Abdel-Halim SM, Isenovi ER, Al-Mulla F. Inflammation and apoptosis in aortic tissues of aged type II diabetes: Amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism. Life Sci. 2010 Apr 11. PMID: 20388520
  23. Kapila K, Anim JT, Francis IM, Al-Mulla F, George SS, Behbehani AI. Expression of estrogen receptor alpha and estrogen receptor beta in fine needle aspirates of breast carcinoma. Acta Cytol. 2010 Jan-Feb;54(1):25-30.PMID: 20306984
  24. Fahd Al-Mulla, RKIP-1 and The Cell Cycle: Novel insight into Genomic Instability (A review), Forum on Immunopathological Diseases and Therapeutics in press.
  25. Patrinos GP, Al Aama J, Al Aqeel A, Al-Mulla F, Borg J, Devereux A, Felice AE, Macrae F, Marafie MJ, Petersen MB, Qi M, Ramesar RS, Zlotogora J, Cotton RG. Recommendations for genetic variation data capture in developing countries to ensure a comprehensive worldwide data collection. Hum Mutat. 2010 Nov 18. [Epub ahead of print]
  26. Kehinde EO, Al-Mulla F, Kapila K, Anim JT. Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer. Scand J Urol Nephrol. 2010 Nov 22. [Epub ahead of print]