Dr. Vickas V. Patel

Penn Cardiovascular Institute
University of Pennsylvania, USA


1995 M.D., School of Medicine, University of Colorado
1994 Ph.D., Physiology and Biophysics, University of Colorado

Publications (Selected)

  1. Rasania, S.P., S. Mountantonakis, V.V. Patel.: Inappropriate ICD Shocks caused byT-wave Oversensing due to Acute Alcohol Intoxication. Pacing and Clinical Electrophysiology. 2011, in press.
  2. Kim, T.K., J.Y. Sul, N.B. Peternko, J.H. Lee, M. Lee, V.V.Patel, J. Kim, J.H. Eberwine.: Transcriptome transfer provides a model for understanding the phenotype of cardiomyocytes.Proceedings of the National Academy of Sciences U.S.A.108:11918-11923,2011.
  3. Rentschler, S., B.S. Harris, L. Kuznekoff, R. Jain, L. Manderfield, M.M. Lu, G.E. Morley, V.V. Patel., J.A. Epstein.: Notch signaling regulates murine atrioventricular conduction and formation of accessory pathways. Journal of Clinical Investigation. 121:525-533, 2011.
  4. Qiao, H., H. Zhang, S. Yamanaka, V.V. Patel, N.B. Petrenko, B. Huang, L.R. Muenz, V.A. Ferrari, K.R. Boheler, R. Zhou.: Long-term improvement in post-infarct left ventricular global and regional contractile function mediated by embryonic stem cell-derived cardiomyocytes. Circ Cardiovasc Imaging. 4:33-41, 2011.
  5. Hawkins, B.J., M.D. Levin, P.J. Doonan, N.B. Petrenko, C.W. Davis, V.V. Patel, M. Madesh.: Mitochondrial complex II preserves hypoxic but not calcium and pro-bcl2 protein induced mitochondrial membrane potential loss. Journal of Biological Chemistry.285:26494-26505,2010.
  6. Riley, M.P., E. Zado, R. Bala, D.J. Callans, J. Cooper, S. Dixit, F. Garcia, E.P. Gerstenfeld, M.D. Hutchinson, D. Lin, V. Patel, R. Verdino, F.E. Marchlinski.: Lack of Uniform Progression of Endocardial Scar in Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy and Ventricular Tachycardia.Circ Arrhythm Electrophysiol. 3:332-338, 2010.
  7. Lijun Y., T. Wang, F. Liu, E.D. Cohen, V.V. Patel.: An evaluation of transmitral and pulmonary venous doppler indices for assessing murine left ventricular diastolic function. Journal of the American Society of Echocardiography, 23:887-897, 2010
  8. Tian, Y., L. Yuan, A.M. Goss, T. Wang, J. Yang, J.J. Lepore, D. Zhou, R.J. Schwartz, V. Patel, E.D. Cohen, E.E. Morrisey.:Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Developmental Cell. 18:275-287, 2010.
  9. Levin, M.D., M.M. Lu, N.B. Petrenko, B.J. Hawkins, T.H. Gupta, D. Lang, P.T. Buckley, J. Jochems, F. Liu, C.F. Spurney, L.J. Yuan, J.T. Jacobson, C.B. Brown, L. Huang, F. Beermann, K.B. Margulies, M. Muniswamy, J.H. Eberwine, J.A. Epstein, V.V. Patel.: Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. Journal of Clinical Investigation. 119:3420-3436, 2009.
  10. Roux J.F., E. Zado, D.J. Callans, F. Garcia, D. Lin, F.E. Marchlinski, R. Bala, S. Dixit, M. Riley, A.M. Russo, M.D. Hutchinson, J. Cooper, R. Verdino, V. Patel, P.S. Joy, E.P. Gerstenfeld.:Antiarrhythmics after ablation of atrial fibrillation (5A Study). Circulation. 120: 1036-1040, 2009.
  11. Wang D., V.V. Patel, E. Ricciottia, R. Zhou, M.D. Levin, E. Gao, Z. Yua, V.A. Ferrari, M.M. Lu, J. Xu, H. Zhang, Y. Hui, Y. Cheng, N. Petrenko, Y. Yu, G.A. FitzGerald.:Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proceedings of the National Academy of Sciences U.S.A. 106: 7548-7552, 2009.
  12. Liu, F., M.D. Levin, N.B. Petrenko, M.M. Lu,T. Wang, L.J. Yuan, A.L. Stout, J.A. Epstein, V.V. Patel.: Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. Journal of Molecular and Cellular Cardiology 45: 715-723, 2008.
  13. Li, J., M.D. Levin, Y. Xiong, N.B. Petrenko, V.V. Patel*, G.L Radice*.: N-cadherin haploinsufficiency affects cardiac gap junkies and arrhythmic susceptibility. Journal of Molecular and Cellular Cardiology 44: 597-606, 2008. *contributed equally to this work.
  14. Dixit, S., E.P.Gerstenfeld, S.J.Ratcliffe,J.M.Cooper,A.M.Russo,S.E.Kimmel,D.J.Callans, D.Lin,R.J.Verdino,V.V.Patel,E.Zado, F.E.Marchlinski.:Single procedure efficacy of isolating all versus arrhythmogenic pulmonary veins on long-term control of atrial fibrillation: A prospective randomized study. Heart Rhythm5: 174-181, 2008.
  15. Ren, J.F., D. Lin, F.E. Marchlinski, D.J. Callans, V. Patel.: Esophageal imaging and strategies for avoiding injury during left atrial ablation for atrial fibrillation. Heart Rhythm 3: 1156-1161, 2006.
  16. Dixit, S., E.P. Gerstenfeld, D.J. Callans, J.M. Cooper, D. Lin, A.M. Russo, R.J. Verdino, V.V. Patel, S.E. Kimmel, S.J. Ratcliffe, H.H Hsia, H.M. Nayak, E. Zado, J.F. Ren, F.E. Marchlinski.: Comparison of cool tip versus 8-mm tip catheter in achieving electrical isolation of pulmonary veins for long-term control of atrial fibrillation: a prospective randomized pilot study. Journal of Cardiac Electrophysiology 17: 1074-1079, 2006.
  17. Russo, A.M., W. Sauer. E.P. Gerstenfeld, H.H. Hsia, D. Lin, J.M. Cooper, S. Dixit, R.J. Verdino, H.M. Nayak, D.J. Callans, V. Patel, F.E. Marchlinski.: Defibrillation threshold testing: is it really necessary at the time of implantable cardioverter-defibrillator insertion? Heart Rhythm 2: 456-461, 2005.
  18. Li, J.*, V.V. Patel*, I. Kostetskii, Y. Xiong, A.F. Chu, J.T. Jacobson, C. Yu, G.E. Morley, J.D. Molkentin, G.L. Radice.: Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circulation Research (Cover) 97: 474-481, 2005. *contributed equally to this work.
  19. Kostetskii, I., J. Li, Y. Xiong, R. Zhou, V.A. Ferrari, V.V. Patel, J.D. Molkentin, G.L. Radice.: Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circulation Research (Cover) 96: 346-354, 2005.
  20. Ismat F.A., M. Zhang, H. Kook, B. Huang, R. Zhou, V.A. Ferrari, J.A. Epstein, V.V. Patel.: The homeobox protein Hop functions in the adult cardiac conduction system. Circulation Research 96: 898-903, 2005.
  21. Rajawat, Y., V.V. Patel, E.P. Gerstenfeld, H. Nayak, F.E. Marchlinski.: Advantages and pitfalls of combining device-based and pharmacological therapies for the treatment of ventricular arrhythmias: experience from a large tertiary center. Pacing Clinical Electrophysiology 27: 1670-1681, 2004.
  22. Rajawat, Y., E.P. Gerstenfeld, V.V. Patel, S. Dixit, D.J. Callans, D.J., F.E. Marchlinski.: Surface ECG criteria for localizing the pulmonary vein origin of spontaneous atrial complexes: validation using intracardiac recordings. Pacing Clinical Electrophysiology 27: 182-188, 2004.
  23. Moskowitz, I.P.G., A. Pizard, V.V. Patel, B.G. Bruneau, J.B. Kim, S.Kupershmidt, D. Roden, C.I. Berul, C.E. Seidman, J.G. Seidman.: The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development 131: 4107-4116, 2004.
  24. Patel, V.V., R.W. Rho, E.P. Gerstenfeld, H.H. Hsia, D.J. Callans, F.E. Marchlinski.: Right bundle branch block ventricular tachycardias: septal versus lateral ventricular origin based on activation time to the right ventricular apex. Circulation 110: 2852-2857, 2004.
  25. Rho, R.W., V.V. Patel, E.P. Gerstenfeld, S. Dixit, J.W. Poku, H.M. Ross, D.J. Callans, D.Z Kocovic.: Elevations in ventricular pacing threshold with the use of the Y-adaptor: implications for biventricular pacing. Pacing Clinical Electrophysiology 26: 747-751, 2003.
  26. Patel, V.V., F.J. Ren, M.E. Jeffrey, T.J. Plappert, M.G. St. John Sutton, F.E. Marchlinski.: A comparison of left artrial volume assessed by magnetic endocardial catheter mapping versus transthoracic echocardiography. American Journal of Cardiology 91: 351-354, 2003.
  27. Patel, V.V., M .Arad, I.P.G. Moskowitz, C.T. Maguire, D. Branco, J.G. Seidman, C.E. Seidman, C.I. Berul.: Electrophysiological characterization and postnatal development of ventricular preexcitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome. Journal of the American College of Cardiology 42: 942-951, 2003.
  28. Maguire, C.T., H. Wakimoto, V.V. Patel, P.E. Hammer, K. Gauvreau, C.I. Berul.: Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies. Physiological Genomics 15: 84-91, 2003.
  29. Dixit, S., E.P. Gerstenfeld, R.W. Rho, V.V. Patel, D.J. Callans, F.E. Marchlinski.: Change in distant atrial activation patterns during circumferential pacemapping of pulmonic vein ostrium: implications for localizing triggers for atrial fibrillation. J Interven Card Electrophysiology 8: 187-194, 2003.
  30. Arad, M., I.P. Moskowitz, V.V. Patel, F. Ahmad, A.R. Perez-Atayde D.B. Sawyer, M. Walter, G.H. Li, P.G. Burgon, C.T. Magurie, D. Stapleton, J.P. Schmidt, X.X. Guo, A. Pizard, S. Kupershmidt, D.M. Roden, C.I. Berul, C.E. Seidman, J.G. Seidman.: Transgenic mice overexpressing mutant PRKAG2 defines the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation 107: 2850-2856, 2003.
  31. Patel, V.V., R.J. Ren, F.E. Marchlinski.: A comparison of left atrial size by transthoracic echocardiography and magnetic catheter mapping. Pacing Clinical Electrophysiology 25: 14-17, 2002.
  32. Callans, D.J., R.J. Ren, N. Narula, V.V. Patel, J. Michele, A. Gelzer, S.M. Dillon.: Left ventricular catheter ablation using direct, intramural ethanol injection in swine. J Interven Card Electrophysiology 6: 225-231, 2002.
  33. Pavri B.B., R.T. Ho, V.V. Patel, D.J. Callans, S. Folley, D.Z. Kocovic.: Unipolar Defibrillator. Pacing Clinical Electrophysiology 24: 244-246, 2001.
  34. Patel, V.V., V.A. Ferrari, N. Narula, S.E. Weigers, M.G. St. John Sutton.: Right ventricular dysplasia in an asymptomatic young man: an uncommon case with biventricular involvement and no known family history. Journal of the American Society of Echocardiography 14: 317-320, 2001.
  35. Patel, V.V., S.R. Levinson.: Surface charge screening and block of the Na+ channel by Ca2+ occurs at two independent sites. Biophysical Journal 68: 2370-2375, 1995.
  36. Lenschow, D.H., V.V. Patel, A. Isabell.: Measurements of the fine-scale structure at the top of the marine stratocumulus. Bulletin of the American Meteorological Society 69: 891-984, 1995.
  37. Patel, V.V., J.H. Caldwell, S.R. Levinson.: Cellular surface charge influences the function of the rskm1 Na+ channel. Neuron 13: 1002-1008, 1994.
  38. Martin, A.R., V.V. Patel, L. Faille, A. Mallart.: Presynaptic calcium currents recorded from calyciform nerve terminals in the lizard cillary ganglion. Neuroscience Letters 105: 14-18, 1989.
  39. Patel, V.V., P. Lagos.: Low-frequency fluctuations of the electric field in the equatorial ionosphere. Nature 13: 559-560, 1985.