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Biography
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Dr. Wael M. Abdel-Rahman

College of Health Sciences

Sharjah University, UAE


Email: whassan@sharjah.ac.ae


Qualifications

2001 Ph.D., Edinburgh University, UK

1995 M.Sc., Histopathology,Zagazig University, Egypt

1989 M.D., Faculty of Medicine, Zagazig University, Egypt


Publications (Selected)

  1. Nieminen TT, Abdel-Rahman WM, Ristimäki A, Lappalainen M, Lahermo P, Mecklin JP, Järvinen HJ, Peltomäki P. BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology. 2011 Jul;141(1):e23-6. Epub 2011 Jun 1. PubMed PMID: 21640116.
  2. Nieminen TT, Gylling A, Abdel-Rahman WM, Nuorva K, Aarnio M, Renkonen-Sinisalo L, Järvinen HJ, Mecklin JP, Bützow R, Peltomäki P. Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia. Clin Cancer Res. 2009 Sep 15;15(18):5772-83. Epub 2009 Sep 1. PubMed PMID: 19723644.
  3. Abdel-Rahman WM. Genomic instability and carcinogenesis: an update. Curr Genomics. 2008 Dec;9(8):535-41. PubMed PMID: 19516960; PubMed Central PMCID: PMC2694557.
  4. Abdel-Rahman WM, Peltomäki P. Lynch syndrome and related familial colorectal cancers. Crit Rev Oncog. 2008;14(1):1-22; discussion 23-31. Review. PubMed PMID: 19105568.
  5. Joensuu EI, Abdel-Rahman WM, Ollikainen M, Ruosaari S, Knuutila S, Peltomäki P. Epigenetic signatures of familial cancer are characteristic of tumor type and family category. Cancer Res. 2008 Jun 15;68(12):4597-605. PubMed PMID: 18559504.
  6. Gylling AH, Nieminen TT, Abdel-Rahman WM, Nuorva K, Juhola M, Joensuu EI, Järvinen HJ, Mecklin JP, Aarnio M, Peltomäki PT. Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors. Carcinogenesis. 2008 Jul;29(7):1351-9. Epub 2008 Jun 12. PubMed PMID: 18550572.
  7. Hahtola S, Burghart E, Jeskanen L, Karenko L, Abdel-Rahman WM, Polzer B, Kajanti M, Peltomäki P, Pettersson T, Klein CA, Ranki A. Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma. J Invest Dermatol. 2008 Sep;128(9):2304-9. Epub 2008 Mar 13. PubMed PMID: 18337827.
  8. Abdel-Rahman WM, Kalinina J, Shoman S, Eissa S, Ollikainen M, Elomaa O, Eliseenkova AV, Bützow R, Mohammadi M, Peltomäki P. Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous beta-catenin. Hum Mutat. 2008 Mar;29(3):390-7. PubMed PMID: 18165946.
  9. Abdel-Rahman WM, Knuutila S, Peltomäki P, Harrison DJ, Bader SA. Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. DNA Repair (Amst). 2008 Feb 1;7(2):321-8. Epub 2007 Dec 26. PubMed PMID: 18162445.
  10. Hahtola S, Burghart E, Puputti M, Karenko L, Abdel-Rahman WM, Väkevä L, Jeskanen L, Virolainen S, Karvonen J, Salmenkivi K, Kinnula V, Joensuu H, Peltomäki P, Klein CA, Ranki A. Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer. Genes Chromosomes Cancer. 2008 Feb;47(2):107-17. PubMed PMID: 17985357.
  11. Ollikainen M, Gylling A, Puputti M, Nupponen NN, Abdel-Rahman WM, Butzow R, Peltomäki P. Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma. Int J Cancer. 2007 Aug 15;121(4):915-20. PubMed PMID: 17471559.
  12. Gylling A, Abdel-Rahman WM, Juhola M, Nuorva K, Hautala E, Järvinen HJ, Mecklin JP, Aarnio M, Peltomäki P. Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study. Gut. 2007 Jul;56(7):926-33. Epub 2007 Jan 31. PubMed PMID: 17267619; PubMed Central PMCID: PMC1994336.
  13. Ollikainen M, Hannelius U, Lindgren CM, Abdel-Rahman WM, Kere J, Peltomäki P.Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach. Oncogene. 2007 Jul 5;26(31):4541-9. Epub 2007 Jan 29. PubMed PMID: 17260015.
  14. Abdel-Rahman WM. Mutations of beta-catenin and KRAS in colorectal carcinomas. Dig Dis Sci. 2006 Mar;51(3):616-7. PubMed PMID: 16614976.
  15. Abdel-Rahman WM, Mecklin JP, Peltomäki P. The genetics of HNPCC: application to diagnosis and screening. Crit Rev Oncol Hematol. 2006 Jun;58(3):208-20. Epub 2006 Jan 23. Review. PubMed PMID: 16434208.
  16. Renkonen ET, Nieminen P, Abdel-Rahman WM, Moisio AL, Järvelä I, Arte S, Järvinen HJ, Peltomäki P. Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous. J Clin Oncol. 2005 Aug 20;23(24):5651-9. PubMed PMID: 16110024.
  17. Kariola R, Abdel-Rahman WM, Ollikainen M, Butzow R, Peltomäki P, Nyström M. APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. Fam Cancer. 2005;4(2):187-90. PubMed PMID: 15951972.
  18. Ollikainen M, Abdel-Rahman WM, Moisio AL, Lindroos A, Kariola R, Järvelä I, Pöyhönen M, Butzow R, Peltomäki P. Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? J Clin Oncol. 2005 Jul 20;23(21):4609-16. Epub 2005 Apr 18. PubMed PMID: 15837969.
  19. Abdel-Rahman WM. Multiple reciprocal translocations in carcinomas. Cancer Genet Cytogenet. 2005 Apr 15;158(2):194-5. PubMed PMID: 15796970.
  20. Abdel-Rahman WM, Ollikainen M, Kariola R, Järvinen HJ, Mecklin JP, Nyström-Lahti M, Knuutila S, Peltomäki P. Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene. 2005 Feb 24;24(9):1542-51. PubMed PMID: 15674332.
  21. Abdel-Rahman WM, Lohi H, Knuutila S, Peltomäki P. Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number. Oncogene. 2005 Jan 20;24(4):706-13. PubMed PMID: 15580308.
  22. Abdel-Rahman WM, Peltomäki P. Molecular basis and diagnostics of hereditary colorectal cancers. Ann Med. 2004;36(5):379-88. Review. PubMed PMID: 15478312.
  23. Raevaara TE, Gerdes AM, Lönnqvist KE, Tybjaerg-Hansen A, Abdel-Rahman WM, Kariola R, Peltomäki P, Nyström-Lahti M. HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1. Genes Chromosomes Cancer. 2004 Jul;40(3):261-5. PubMed PMID: 15139004.
  24. Renkonen E, Zhang Y, Lohi H, Salovaara R, Abdel-Rahman WM, Nilbert M, Aittomaki K, Jarvinen HJ, Mecklin JP, Lindblom A, Peltomaki P. Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer. J Clin Oncol. 2003 Oct 1;21(19):3629-37. PubMed PMID: 14512394.
  25. Raevaara TE, Vaccaro C, Abdel-Rahman WM, Mocetti E, Bala S, Lönnqvist KE, Kariola R, Lynch HT, Peltomäki P, Nyström-Lahti M. Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein. Gastroenterology. 2003 Aug;125(2):501-9. PubMed PMID:12891553.
  26. Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ, Wyllie AH, Edwards PA. Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2538-43. Epub 2001 Feb 20. PubMed PMID: 11226274; PubMed Central PMCID: PMC30173.
  27. Abdel-Rahman W, Arends M, Morris R, Ramadan M, Wyllie A. Death pathway genes Fas (Apo-1/CD95) and Bik (Nbk) show no mutations in colorectal carcinomas. Cell Death Differ. 1999 May;6(5):387-8. PubMed PMID: 10381638.
  28. Abdel-Rahman WM, Georgiades IB, Curtis LJ, Arends MJ, Wyllie AH. Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis. Oncogene. 1999 Mar 25;18(12):2139-42. PubMed PMID: 10321738.