Return
Biography
1

Dr. Jonathan R. Keller

National Cancer Insititute-NIH, USA


Email: kellerjo@mail.nih.gov


Qualifications


1985 Ph.D., George Washington University, Washington, USA

1978 B.S., University of Maryland, College Park, Maryland, USA


Publications(Selected)

  1. Du Y, Campbell JL, Nalbant D, Youn H, Bass AC, Cobos E, Tsai S, Keller JR and Williams SC:  Mapping gene expression patterns during myeloid differentiation using the EML hematopoietic progenitor cell line.  Exp. Hematol. 30: 649-658, 2002.
  2. Liu P, Keller JR, Ortiz M, Tessarollo L, Rachel RA, Nakamura T, Jenkins NA and Copeland NG:  Bcl11a is essential for normal lymphoid development. Nat. Immunol. 4: 525-532, 2003.
  3. McCauslin CS, Wine J, Cheng L, Klarmann KD, Candotti F, Clausen PA, Spence SE and Keller JR:  In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knockout animals. Blood 102:  843-848, 2003.
  4. Klarmann K, Ortiz M, Davis M and Keller JR: Identification of in vitro growth conditions for c-Kit-negative hematopoietic stem cells. Blood 102: 3120-3128, 2003.
  5. Asefa B, Klarmann KD, Copeland NG, Gilbert DJ, Jenkins NA and Keller JR: The interferon-inducible p200 family of proteins: A perspective on their roles in cell cycle regulation and differentiation.  Blood Cells Mol. Dis. 32: 155-167, 2004.
  6. Sharov A, Piao1 Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant A, Kunath T, Hogan BM, Curci A, D’Urso M, Kelso J, Hide W, and Ko MS: Transcriptome analysis of mouse stem cells and early embryos.  PloS Bio. 1:  410-419, 2004.
  7. Radosevic N, Winterstein D, Keller JR, Neubauer H, Pfeffer K and Linnekin D: JAK2 contributes to the intrinsic capacity of primary hematopoietic cells to respond to stem cell factor. Exp. Hematol. 32: 149-156, 2004.
  8. Jiang Q, Li WQ, Hofmeister RR, Young HA Hodge DR Keller JR, Khaled AR and Durum SK: Distinct regions of the interleukin-7 receptor regulate different Bcl-2 family members. Mol. Cell. Biol. 24: 6501-6513, 2004.
  9. Li WQ, Jiang Q, Khaled AR, Keller JR, and Durum SK: Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. J. Biol. Chem. 279: 299160-19166, 2004.
  10. Dermott JM, Gooya JM, Asefa B, Weiler SR, Smith M and Keller JR: Inhibition of growth by p205: A nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation. Stem Cells 22:  832-848, 2004.
  11. Heath V, Suh HC, Holman M, Renn K, Gooya JM, Parkin S, Klarmann KD, Ortiz M, Johnson P, and Keller J: C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood 104: 1639-1647, 2004.
  12. Jiang Q, Li WQ, Aiello FB, Klarmann KD, Keller JR and Durum SK: Retroviral transduction of IL-7Rα into IL-7Rα-/- bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia.  Gene Ther. 12: 1761-1768, 2005.
  13. Leeanansaksiri W, Wang H, Gooya JM, Renn K, Abshari M, Tsai S and Keller JR: IL-3 induced inhibitor of DNA-binding protein-1 in hematopoietic progenitor cells and promotes myeloid cell development. J. Immunol. 174: 7014-7021, 2005.
  14. Drutskaya MS, Ortiz M, Liepinsh DJ, Kuprash DV, Nedospasov SA and Keller JR: Inhibitory effects of tumor necrosis factor on hematopoiesis seen in vitro and translated to increased numbers of both committed and multipotent progenitors in TNF-deficient mice. Exp. Hematol. 33:  1348-1356, 2005.
  15. Liepinsh DJ, Grivennikov SI, Klarmann KD, Lagarkova MA, Drutskaya MS, Lockett SJ, Tessarollo L, McAuliffe M, Keller JR, Kuprash DV and Nedospasov SA: Novel lymphotoxin alpha (Ltά) knockout mice with unperturbed tumor necrosis factor expression: reassessing the Ltά biological functions. Mol. Cell. Biol. 26: 4214-4225, 2006.
  16. Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ and Keller JR: p205 a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. FEBS Lett. 580: 1205-1214, 2006.
  17. Suh HC, Gooya J, Renn K, Friedman AD, Johnson PF and Keller JR: C/EBPα determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation. Blood 107: 4308 – 4316, 2006.
  18. Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P: Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation. Dev. Cell 10: 563-573, 2006.
  19. Aiello FB, Keller JR, Klarmann KD, Dranoff G, Mazzucchelli R, Durum SK: IL-7 Induces Myelopoiesis and Erythropoiesis. J. Immunology 78: 1553-1563, 2007.
  20. Jiang Q, Huang J, Li W, Cavinato T, Keller JR, and Durum SK: Role of the intracellular domain of IL-7 receptor in T cell development. J. Immunology 178: 228-232, 2007.