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Biography

Prof. Andrew William Heath

Department of Infection and Immunity

University of Sheffield, UK


Email: a.w.heath@sheffield.ac.uk


Qualifications

1985 Ph.D., Virology, University of Sheffield, UK

1981 B.Sc., Microbiology, University of Sheffield, UK


Publications (selected)

  1. Foster RA, Carlring J, Lees A, Borrow R, Ramsay M, Kacsmarski E, Miller E, McKendrick MW, Heath AW Read RC. (2010) Functional T cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the Meningococcal serogroup C conjugate vaccine. Clin Vac Immunol 2010 17 1104-1110
  2. Rezaei N, Wing J, Aghamohammadi A, Carlring J, Lees A, Asgarian-Omran H, Pourpak Z, Sarrafnejad A, Kardar GA, Shahrestani T, Masoumi F, Zare A, Saghafi S, Sarrafnejad S, Foster RA, Heath AW, Read RC. (2010). B cell-T cell activation and interaction in common variable immunodeficiency. Human Immunology 71 355-362
  3. Bhagawati-Prasad VNS, DeLeenheer E, Keefe NP, Ryan LA, Carlring J, Heath AW. (2010). CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis. J. Immune Based Therapies and Vaccines. 8. 1
  4. Foster RA, Carlring J, McKendrick MW, Lees A, Borrow R, Read RC, Heath AW. (2009) Evidence of a functional B cell immunodeficiency in adults who experience serogroup C meningococcal disease. Clin.Vac.Immunol. 16 692-698
  5. Hatzifoti C and Heath AW (2009)Influenza in the elderly. Chapter 6. In; Microbiology and Aging. Percival SL, Editor. Humana press
  6. Hatzifoti C, Bacon A, Marriot H, Laing P and Heath AW (2008). Liposomal co-entrapment of CD40mAb enhances IgG responses against bacterial polysaccharide and protein. PLoS ONE 3 e2368
  7. Hatzifoti C and Heath AW (2007). CD40 mediated enhancement of immune responses against three forms of influenza vaccine. Immunology 122 98-106
  8. Nimal S, Thomas MS and Heath AW (2007). Fusion of antigen to Fas ligand in a DNA vaccine enhances immunogenicity. Vaccine 25 2306-2315.
  9. Duffy D, Yang C-P, Heath A, Garside P, Bell EB (2006). Naïve T cell receptor transgenic T cells help memory B cells produce antibody. Immunology 119 376-384
  10. Nimal S, Heath AW and Thomas M (2006). Enhancement of immune responses to an HIV gp120 DNA vaccine by fusion to TNF alpha cDNA. Vaccine 24 3298-3308
  11. Barr T, Carlring J and Heath AW (2006)Host derived molecules and antibodies against them as adjuvants. Chapter 3. In: Immunopotentiators in Modern Vaccines. Schijns and O’Hagan Editors. Academic Press.
  12. Barr TA, Carlring J and Heath AW (2006) Costimulatory agonists as immunological adjuvants. Vaccine 24 3399-3407
  13. Nimal S, McCormick AL, Thomas M and Heath AW (2005). An interferon gamma gp120 fusion delivered as a DNA vaccine induces enhanced priming. Vaccine 23 3984-3990
  14. Barr TA, Carlring J and Heath AW (2005). CD40 antibody as a potent immunological adjuvant: CD40 antibody provides the CD40 signal to B cells but does not substitute for T cell help in responses against TD antigens. Vaccine 23 3477-3482.
  15. Carlring JU, Barr TA and Heath AW (2005)Adjuvanticity of CD40 antibodies. Invited review. Curr.Opin.Mol.Ther. 7 73-77
  16. Carlring J, Barr TA, McCormick AL and Heath AW (2004). CD40 antibody as an adjuvant induces enhanced T cell responses. Vaccine 22 3323-3328
  17. Barr TA, McCormick AL, Carlring J and Heath AW (2004).A potent adjuvant effect of CD40 antibody attached to antigen. Immunology 109 87-91
  18. Carlring J, Barr T, Buckle AM and Heath AW (2003). Anti-CD28 has a potent adjuvant effect on the antibody response to soluble antigens mediated through CTLA4 by-pass. Eur.J.Immunol. 33 135-142
  19. Barr TA, Laing PL and Heath AW (2003). Understanding and rational design of immunological adjuvants. Innovations in Pharmaceutical technology 3 71-79
  20. Simms JR, Jennings R, Richardson VJ and Heath AW. (2002) Large-scale comparison of experimental adjuvants with Herpes Simplex Virus vaccine reveals a correlation of protection with IgG2a and IgG2b responses. J.Med Virol. 68 82-91
  21. McCormick AL, Thomas MS and Heath AW (2001). Immunization with an Interferon–gp120 Fusion Protein Induces Enhanced Immune Responses to Human Immunodeficiency Virus gp120. J.Inf Dis 184 1423-1430
  22. Mohamedi SA, Heath AW and Jennings R. (2001) A comparison of oral and parenteral routes for therapeutic vaccination with HSV-2 ISCOMs in mice: cytokine profiles, antibody responses and protection. Antiviral Res. 49 83-99
  23. Demangel C, Palendira U, Feng CG, Heath AW, Bean, AGD and Britton WJ. (2001) Stimulation of dendritic cells via CD40 enhances the immune responses to Mycobacterium tuberculosis infection. Infect Immun 69 2456-2461
  24. Barr TA and Heath AW (2001). Functional activity of anti-CD40 mAbs correlates to the position of binding relative to CD154. Immunology 102 39-43


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