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Biography

Prof. Kyoko Tsukiyama-Kohara

Transboundary Animal Diseases Center
Department of Animal Hygiene
Joint Faculty of Veterinary Medicine
Kagoshima University, Japan


Email: kkohara@agri.kagoshima-u.ac.jp, kkohara@vet.kagoshima-u.ac.jp


Qualifications

1989 Ph.D., Agriculture, Tokyo University, Tokyo

1985 M.Sc., Veterinary Medicine, Hokkaido University, Japan

1983 B.Sc., Veterinary Medicine, Hokkaido University, Japan


Publications(selected)

  1. Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto Y, Kusanagi I, Fujiwara S, Tsukada T, Aoki Y, Klumpp K,Tsukiyama-Kohara K,El-Gohary A, Sudoh M, Kohara M. A serine palmytoiltransferase inhibitor inhibits hepatitis C virus replication in human hepatocytes.Gastroenterologydoi:pii: S0016-5085(13)00914-1. 10.1053.
  2. Tsukiyama-KoharaK*,Katsume A, Kimura K, Saito M, Kohara M. 4E-BP1 regulates the differentiation of white adipose tissue.Genes Cells. Jul;18(7):602-607, 2013.
  3. Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M,Tsukiyama-KoharaK,Inoue K, Yoshiba M, Takaoka A, Kohara M.Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.PLoS One. 8(3) e59611, 2013.
  4. Salem NE, Saito M, Kasama Y, Ozawa M, Kawabata T, Harada S, Suda H, Asonuma K, El-Gohary A,Tsukiyama-Kohara K.Genomic polymorphisms in 3β-hydroxysterol Δ24-reductase promoter sequences.Microbiol Immunol.Mar;57(3) 179-184, 2013.
  5. Sekiguchi S, Kimura K, Chiyo T, Ohtsuki T, Tobita Y, Tokunaga Y, Yasui F,Tsukiyama-Kohara K,Wakita T, Tanaka T,Miyasaka M, Mizuno K, Hayashi Y, Hishima T, Matsushima K and Kohara M. Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppr esses viral protein levels in mouse liver.Pros One, 7(12) e51656, 2012.
  6. Tsukiyama-Kohara K.Role of Oxidative stress in hepatocarcinogenesis induced by hepatitis C virus.Int. J. Mol. Sci.13, 15271-15278,2012.
  7. Inoue K,Tsukiyama-Kohara K,Matsuda C, Yoneyama M, Fujita T, Kuge S, Yoshiba M, and Kohara M. Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1.Biochem. Biophys. Res. Com.30;428(4) 494-499, 2012.
  8. Saitou M, Kohara, M,Tsukiyama-Kohara K*.Hepatitis C virus promotes expression of the 3β-hydroxysterol Δ24-reductase through Sp1.J. Med. Virol., 84: 733-746 (2012).
  9. Kasama Y, Saito M, Takano T, Nishimura T, Satoh M, Wang Z,Nagla. E S, Harada S, Kohara M,Tsukiyama-Kohara K*.Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3. Virus Res., 163: 405-409 (2012).
  10. Satoh M, Saito M, Takano T, Kasama Y, Nishimura T, Nishito Y, Hirata Y, Arai M, Sudoh M, Kai C, Kohara M,Tsukiyama-Kohara K*.Monoclonal antibody 2-152a suppresses hepatitis C virus infection thoroughbetaine/GABA transporter-1.J. Infect. Dis.,204(8):1172-1180 (2011).
  11. Takano T,Tsukiyama-Kohara K*, Hayashi M, Hirata Y, Satoh M, Tateno C, Hayashi Y, Hishima T, Funata N, Sudo M, and Kohara M.Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes..J. Hepatology55(3) 512-521 (2011).
  12. Takano T, Kohara M, Kasama Y, Nishimura T, Saito M, Kai C,Tsukiyama-Kohara K*. Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response.J. Med. Virol.,83, 801-809 (2011).
  13. Tsukiyama-Kohara K*, Sekiguchi S, Kasama Y, Nagla ES, Machida K, Kohara M. Hepatitis C virus-related lymphomagenesis in a mouse model. ISRNHematology,2011: 167501 (2011).
  14. Kasama Y, Satoh M, Saito M, Okada S, Kai C, andTsukiyama-Kohara K*.Potential of a recombinant measles virus as expression vector of hepatitis C virus envelope proteins.World J. Vaccine.1 98-103 (2011).
  15. Kasama Y, Sekiguchi S, Saito M, Tanaka K, Satoh M, Kuwahara K, Sakaguchi N, Takeya M, Hiasa Y, Kohara M,Tsukiyama-Kohara K.Persistent expression of the full genome of hepatitis C virus in B cells inducesspontaneous development of B-cell lymphomasin vivo. Blood116(23):4926-4933, 2010.
  16. Satoh M, Saito M, Tanaka K, Iwanaga S, Salem NE, Seki T, Okada S, Kohara M, Harada S, Kai C,Tsukiyama-Kohara K.Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse.Comp. Immunol. Immunopathol.33 E81-88, 2010.
  17. Amako Y,Tsukiyama-Kohara K, Katsume A, Hirata Y, Sekiguchi S, Tobita Y, Hayashi Y, Hishima T, Funata N, Yonekawa H, Kohara M. Pathogenesis of hepatitis C virus infection inTupaia belangeri.J. Virology84 303-311, 2010.
  18. Nishimura T, Kohara M, Izumi K, Kasama Y, Hirata Y, Huang Y, Shuda M, Mukaidani C, Takano T, Tokunaga Y, Nuriya H, Satoh M, Saito M, Kai C. andTsukiyama-Kohara K.HEPATITIS C VIRUS IMPAIRS P53 VIA PERSISTENT OVER-EXPRESSION OF 3ß-HYDROXYSTEROL∆24-REDUCTASEJ. Biol. Chem.284 36442-36452, (2009)
  19. K. Saitou, K. Mizumoto, T. Nishimura, C. Kai andK. Tsukiyama-Kohara. Hepatitis C virus core protein facilitates the degradation of Ku70 and reduces DNA-PK activity in hepatocytes.Virus Research144 266-271, (2009).
  20. Keigo Machida,Kyoko Tsukiyama-Kohara, Eiji Seike, Shigenobu Tóne, Yukiko Hayashi, Yuri Kasama, Masumi Shimizu, Hidemi Takahashi, Chyoji Taya, Hiromichi Yonekawa, Nobuyuki Tanaka, and Michinori Kohara. Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins.Gastroenterology(2009) 137:285-296, (2009).
  21. Inhibition of host protein synthesis in B95a cells infected with the HL strain of measles virus. Y. Inoue,K. Tsukiyama-Kohara,M. Yoneda, H. Sato, and *C. Kai.Comp. Immunol. Microbiol. Infect. Dis. 32 (1):29-41, (2009).
  22. Comparative Aspects on the Role of Polypyrimidine Tract Binding Protein in Internal Initiation of Hepatitis C Virus and Picornavirus RNAs. T.Nishimura, M.Saito, T.Takano, A. Nomoto, M. Kohara, andK. Tsukiyama-Kohara.Comp. Immunol. Microbiol. Infect. Dis. (5):435-48 (2008).
  23. ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic ß Cell Survival under Endoplasmic Reticulum Stress. S. Yamaguchi, *H. Ishihara, T. Yamada, A. Tamura, M. Usui, R. Tominaga, Y. Munakata, C. Satake, H. Katagiri, F. Tashiro, H. Aburatani,K. Tsukiyama-Kohara,J. Miyazaki, N. Sonenberg and Y. Oka.Cell Metabolism7(3):269-76 (2008).
  24. Measles virus induces cell-type specific changes in gene expression. H. Sato, R. Honma, M.Yoneda, R. Miura, K. Tsukiyama-Kohara, F. Ikeda, T. Seki, S.Watanabe, and *C. Kai.Virology5;375(2):321-330 (2008).
  25. Heparin-like glycosaminoglycans prevent the infection of measles virus in SLAM-negative cell lines. Y. Terao-Muro, M. Yoneda, T. Seki, A. Watanabe,K. Tsukiyama-Kohara,K.Fujita, and *C. Kai.Antiviral Res. 80(3) 370-376 (2008).


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