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Biography
CHEN

Prof. Wangxue Chen

Human Health Therapeutics, National Research Council

Canada


Email: wangxue.chen@nrc.gc.ca


Qualifications

1990 Ph.D., Massey University, New Zealand

1987 M.Phil., Massey University, New Zealand

1982 D.V.M., Zhejiang Agricultural University, China


Publications (selected)

  1. Altman E, Chandan V, Harrison BA, Veloso-Pita R, Li J, Kuolee R, Chen W, Verez-Bencomo V. Design and immunological properties of Helicobacter pylori glycoconjugates based on a truncated lipopolysaccharide lacking Lewis antigen and comprising an alpha-1,6-glucan chain. Vaccine 2012; 30:7332-41.
  2. Aubry A, Hussack G, Chen W, KuoLee R, Twine SM, Fulton KM, Foote S, Carrillo CD, Tanha J, Logan SM. Modulation of toxin production by the flagellar regulon in Clostridium difficile. Infect Immun 2012; 80:3521-32.
  3. Boltje TJ, Zhong W, Park J, Wolfert MA, Chen W, Boons GJ. Chemical Synthesis and Immunological Evaluation of the Inner Core Oligosaccharide of Francisella tularensis. Journal of the American Chemical Society 2012; 134:14255-62.
  4. de Leseleuc L, Harris G, KuoLee R, Chen W. In vitro and in vivo biological activities of iron chelators and gallium nitrate against Acinetobacter baumannii. Antimicrobial agents and chemotherapy 2012; 56:5397-400.
  5. Qiu H, KuoLee R, Harris G, Van Rooijen N, Patel GB, Chen W. Role of macrophages in early host resistance to respiratory Acinetobacter baumannii infection. PLoS One 2012; 7:e40019.
  6. Twine S, Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W. BALB/c mice, but not C57BL/6 mice immunized with a DeltaclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge immune responses. Vaccine 2012; 30:3634-45.
  7. Zhou P, Hu R, Chandan V, Kuolee R, Liu X, Chen W, Liu B, Altman E, Li J. Simultaneous analysis of cardiolipin and lipid A from Helicobacter pylori by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Mol Biosyst 2012; 8:720-5.
  8. Harris G, Chen W. Profiling of cytokine and chemokine responses using multiplex bead array technology. Methods in molecular biology (Clifton, NJ) 2013; 1061:265-78.
  9. Resume
  10. Harris G, Kuo Lee R, Lam CK, Kanzaki G, Patel GB, Xu HH, Chen W. A mouse model of Acinetobacter baumannii-associated pneumonia using a clinically isolated hypervirulent strain. Antimicrobial agents and chemotherapy 2013; 57:3601-13.
  11. Riazi A, Strong PC, Coleman R, Chen W, Hirama T, van Faassen H, Henry M, Logan SM, Szymanski CM, Mackenzie R, et al. Pentavalent Single-Domain Antibodies Reduce Campylobacter jejuni Motility and Colonization in Chickens. PLoS One 2013; 8:e83928.
  12. Ryden P, Twine S, Shen H, Harris G, Chen W, Sjostedt A, Conlan W. Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria. Molecular immunology 2013; 54:58-67.
  13. de Leseleuc L, Harris G, KuoLee R, Xu HH, Chen W. Serum resistance, gallium nitrate tolerance and extrapulmonary dissemination are linked to heme consumption in a bacteremic strain of Acinetobacter baumannii. Int J Med Microbiol 2014; 304:360-9.
  14. Vinogradov E, Maclean L, Xu HH, Chen W. The structure of the polysaccharide isolated from Acinetobacter baumannii strain LAC-4. Carbohydrate research 2014; 390:42-5.
  15. Bruhn KW, Pantapalangkoor P, Nielsen T, Tan B, Junus J, Hujer KM, Wright MS, Bonomo RA, Adams MD, Chen W, et al. Host Fate is Rapidly Determined by Innate Effector-Microbial Interactions During Acinetobacter baumannii Bacteremia. The Journal of infectious diseases 2015; 211:1296-305.
  16. Chen W. Current advances and challenges in the development of Acinetobacter vaccines. Human Vaccines & Immunotherapeutics 2015.
  17. KuoLee R, Harris G, Yan H, Xu HH, Conlan WJ, Patel GB, Chen W. Intranasal immunization protects against Acinetobacter baumannii-associated pneumonia in mice. Vaccine 2015; 33:260-7.
  18. Ou HY, Kuang SN, He X, Molgora BM, Ewing PJ, Deng Z, Osby M, Chen W, Xu HH. Complete genome sequence of hypervirulent and outbreak-associated Acinetobacter baumannii strain LAC-4: epidemiology, resistance genetic determinants and potential virulence factors. Sci Rep 2015; 5:8643.
  19. Su F, Xue Y, Wang Y, Zhang L, Chen W, Hu S. Protective effect of ginsenosides Rg1 and Re on LPS-induced sepsis by competitive binding to Toll-like receptor 4. Antimicrobial agents and chemotherapy 2015; in press.