Prof. Vladimir L. Motin

Department of Pathology/ Department of Microbiology & Immunology

University of Texas Medical Branch, USA



1988 Ph.D., Gamaleya Research Institute for Epidemiology and Microbiology, Russia

1983 B.Sc., Moscow Institute for Engineering and Physics, Russia

Publications (selected)

  1. Abramov VM, Khlebnikov VS, Vasiliev AM, Kosarev IV, Vasilenko RN, Kulikova NL, Khodyakova AV, Evstigneev VI, Uversky VN, Motin VL, Smirnov GB, Brubaker RR. Attachment of LcrV from Yersinia pestis at Dual Binding Sites to Human TLR-2 and Human IFN-gamma Receptor. J Proteome Res. 6:2222-2231; 2007. PMID: 17441749.
  2. Feodorova, V.A., L.N. Pan’kina, E.P. Savostina, L.V. Sayapina, V.L. Motin, S.V. Dentovskaya,  R.Z. Shaikhutdinova, S.A. Ivanov, B. Lindner, A.N. Kondakova, O.V. Bystrova, N.A. Kocharova, S.N. Senchenkova, O. Holst, G.B. Pier, Y.A. Knirel, A.P. Anisimov. Yersinia pestis EV NIIEG ΔlpxM live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Vaccine. 25:7620-7628; 2007. PMID: 17913308.
  3. Kim, T.-J., S. Chauhan, V.L. Motin, E.-B. Goh, M.M. Igo and G.M. Young. Direct transcriptional regulation of the plasminogen activator gene of Yersinia pestis by the cyclic AMP receptor protein. J Bacteriol. 189:8890-900; 2007. PMID: 17933899.
  4. Agarkov, A., S. Chauhan, P.J. Lory, S.R. Gilbertson and V. L. Motin. Substrate specificity and screening of the integral membrane protease Pla. Bioorg. Med. Chem. Lett.18:427-431; 2008. PMID: 17981463.
  5. Garcia, E., P. Chain, J.M. Elliott, A.G. Bobrov, V.L. Motin, O.A. Kirillina, V. Lao, R.  Calendar, and A.  Filippov. Molecular characterization of L-413C, a P2-related plague diagnostic bacteriophage. Virology 372:85-96; 2008. PMID: 18045639.
  6. Sha, J., Agar, S.L., Baze, W.B., Olano, J.P., Fadl, A.A., Erova, T.E., Wang, S., Foltz, S.M., Suarez, G., Motin, V.L., Chauhan, S., Klimpel, G.R., Peterson, J.W., and Chopra, A.K. Braun Lipoprotein (Lpp) contributes to the virulence of Yersiniae: potential role of Lpp in inducing bubonic and pneumonic plague. Infect.Immun. 76:1390-1409; 2008. PMID: 18227160.
  7. Feodorova, V.A., L.N. Pan’kina, E.P. Savostina, O.V. Kuznetsov, N.P. Konnov, L.V. Sayapina, S.V. Dentovskaya,  R.Z. Shaikhutdinova, S.A. Ageev, B. Lindner, A.N. Kondakova, O.V. Bystrova, N.A. Kocharova, S.N. Senchenkova, O. Holst, G.B. Pier, Y.A. Knirel, A.P. Anisimov, and V.L. Motin. Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive      antigens. Vaccine 27:2240-2250; 2009. PMID: 19428838.
  8. Endsley, J.J., Torres, A.G., Gonzales, C.M., Kosykh, V.G., Motin, V.L., Peterson, J.W., Estes, D.M., Klimpel, G.R. Comparative antimicrobial activity of granulysin against bacterial biothreat agents. Open Microbiol. J. 3:92-96; 2009. PMID: 19587798.
  9. Robinson, J.B., M.V. Telepnev, I.V. Zudina, D. Bouyer, J.A. Montenieri, S.W. Bearden, K.L. Gage, S.L. Agar, S.M. Foltz, S. Chauhan, A.K. Chopra and V.L. Motin. Evaluation of a Yersinia pestis Mutant Impaired in a Thermoregulated Type VI-Like Secretion System in Flea, Macrophage and Murine Models. Microb Pathogen  47:243-251; 2009. PMID: 19716410.
  10. Telepnev, M.V., G.R. Klimpel, J. Haithcoat, Y.A. Knirel, A.P. Anisimov and V.L. Motin. Tetra-acylated lipopolysaccharide of Yersinia pestis can inhibit multiple Toll-Like Receptor (TLR)-mediated signaling pathways in human dendritic cells. J Infect Dis 200:1694-1702; 2009. PMID: 19863438.
  11. Anisimov, A.P., S.V. Dentovskaya, E.A. Panfertsev, T.E. Svetoch, P.Kh. Kopylov, B.W. Segelke, A. Zemla, M.V. Telepnev and V.L. Motin. Amino acid and structural variability of Yersinia pestis LcrV protein. Infect Genet Evol 10:137-145; 2010. PMID: 19835996.
  12. Colborn,  J.M., M.Y. Kosoy, V.L. Motin, M.V. Telepnev, G. Valbuena, K.S. Myint, Y. Fofanov, C. Putonti, C. Feng and L. Peruski. Improved detection of Bartonella DNA in mammalian hosts and arthropod vectors using the NADH dehydrogenase gamma subunit (nuoG). J Clin Microbiol 48:4630-4633; 2010. PMID: 20926707.
  13. Sha, J., J.J. Endsley, M.L. Kirtley, S.M. Foltz, M. B. Huante, T.E. Erova, E.V. Kozlova, V.L. Popov, L.A. Yeager, I.V. Zudina, V.L. Motin,  J.W. Peterson, K.L. DeBord, and A.K. Chopra. Characterization of an F1 deletion mutant of Yersinia pestis CO92, pathogenic role of F1 antigen in bubonic and pneumonic plague, and evaluation of the sensitivity and specificity of F1 antigen capture-based dipsticks. J Clin Microbiol 49:1708-1715; 2011. PMID: 21367990.
  14. Charusanti, P., S. Chauhan, K. McAteer, J.A. Lerman, D.R. Hyduke, V.L. Motin, C. Ansong, J.N. Adkins, and B.O. Palsson. An experimentally-supported genome scale metabolic network reconstruction for Yersinia pestis CO92. BMC Systems Biology 5: 163; 2011. PMID: 21995956.
  15. Schrimpe-Rutledge, A., M. Jones, S. Chauhan, S. Purvine, J. Sanford, M. Monroe, H. Brewer, S. Payne, C. Ansong, B. Frank, R. Smith, S. Peterson, V. Motin, J. Adkins. Comparative ‘Omics’ driven genome annotation refinement: Application across multiple Yersiniae including plague strains. PLoS One. 7:e33903; 2012. PMID: 22479471.
  16. Ansong, C, Deatherage, B.L,  Hyduke, D., Schmidt, B., Mcdermott, J.E., Jones, M.B., Chauhan, S., Charusanti, P.,  Kim, Y.-Mo, Nakayasu, E., Jie, L., Afshan, K., Niemann, G., Brown, R.N., Metz, T.O., McAteer, K., Heffron, F., Peterson, S.N., Motin, V.L., Palsson, B.O., Smith, R.D., and Adkins, J.N. Studying Salmonellae and Yersiniae Host-Pathogen Interactions Using Integrated 'Omics and Modeling Integrating Host-Pathogen Interactions using Omics and Modeling for Pathogenic Salmonellae and Yersiniae. Curr Top Microbiol Immunol. 363:21-41; 2013. PMID: 22886542.
  17. Ansong A., A.C. Schrimpe-Rutledge, H. Mitchell, S. Chauhan, M.B. Jones, Y-Mo Kim, K. McAteer, B. Deatherage, J. L. Dubois, H. M. Brewer, B. C. Frank, J. E. McDermott, T. O. Metz, S. N. Peterson, V. L. Motin and J. N. Adkins. A mutli-omic systems approach to elucidating Yersinia virulence mechanisms. Mol Biosyst. 9:44-54; 2013. PMID: 23147219.
  18. Erova, T., J.Rosenzweig, J. Sha, G. Suarez, J. Sierra, M. Kirtley, C. van Lier, M. Telepnev, V. Motin, and A. Chopra. Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new generation recombinant plague vaccine. Clin Vaccine Immunol. 20:227-238; 2013. PMID: 23239803.
  19. Willias, S.P., Chauhan, S., and Motin, V.L. Functional Characterization of Yersinia pestis Aerobic Glycerol Metabolism. Microb Pathogen 76:33-43; 2014. PMID: 25220241.
  20. Tiner B.L.., Sha J., Kirtley M.L., Erova T.E., Popov V.L., Baze W.B., van Lier C.J., Ponnusamy D., Andersson J.A., Motin V.L., Chauhan S., and Chopra A.K. Combinational deletion of three membrane protein-encoding genes highly attenuates Yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague. Infect Immun 83:1318-1338; 2015. PMID: 25605764.
  21. van Lier C.J., Tiner B.L., Chauhan S., Motin V.L., Fitts E.C., Huante M.B., Endsley J.J., Ponnusamy D., Sha J., Chopra A.K.Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages. Microb Pathog 80:27-38; 2015. PMID: 25697665.