Dr. Ramakrishnan Gopalakrishnan
Department of Medicine
University of Southern California, USA
2010 Postdoctoral Research
Associate, University of Southern California, Hematology
2008 Ph.D., University of
2004 M.Sc., University of
2002 B.Sc., University of Madras, Biochemistry
Gopalakrishnan R, Matta H, Tolani B, Tim Triche Jr., and Chaudhary PM.
Immunomodulatory drugs IKZF1-IRF4-MYC axis in primary effusion lymphoma in a
cereblon-dependent manner and display synergistic cytotoxicity with BRD4
inhibitors. Oncogene. 2015 (Accepted manuscript, in press.)
Tolani B, Matta H, Gopalakrishnan R, Punj V, Chaudhary PM. NEMO is
essential for KSHV-encoded vFLIP K13-induced gene expression and protection
against death receptor-induced cell death and its N-terminal 251 residues are
sufficient for this process. J Virol. 2014, Jun; 88(11):6345-54.
Sundaram J, Keshava S, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LVM. Factor
VIIa binding to endothelial cell protein C receptor protects vascular barrier
integrity in vivo. J Thromb Haemost. 2014 May;12(5):690-700.
Gopalakrishnan R, Matta H and Chaudhary PM. A purine scaffold HSP90
inhibitor BIIB021 has selective activity against KSHV associated Primary
Effusion Lymphoma and blcoks vFLIP K13-induced NF-κB. Clin Cancer Res. 2013 Sep
Tolani B, Gopalakrishnan R, Punj V, Matta H and Chaudhary PM. Targeting
Myc in KSHV-associated Primary effusion lymphoma with BET bromodomain
inhibitors. Oncogene, 2014 May 29; 33(22):2928-37.
Gopalakrishnan R, Sundaram J, Sattu K, Pandi A, Thiruvengadam D. Dietary
supplementation of silymarin is associated with decreased cell proliferation,
increased apoptosis, and activation of detoxification system in hepatocellular
carcinoma. Mol Cell Biochem. 2013 May;377(1-2):163-76
Gopalakrishnan R, Pendurthi UR, Hedner U, Agersø H, Esmon CT and Rao LV.
Influence of endothelial cell protein C receptor on plasma clearance of factor
VIIa. J Thromb Haemost. 2012 May;10(5):971-3.
Matta H, Gopalakrishnan R, Graham
C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM. Kaposi's Sarcoma Associated
Herpesvirus Encoded Viral FLICE Inhibitory Protein K13 Activates NF-κB Pathway Independent of TRAF6, TAK1 and
LUBAC. PLoS One. 2012;7(5):e36601. Epub 2012 May 8.
Sen P, Clark CA, Gopalakrishnan R, Hedner U, Esmon CT, Pendurthi UR, Rao
LV. Factor VIIa binding to endothelial cell protein C receptor: differences
between mouse and human systems. Thromb Haemost. 2012 May;107(5):951-61.
Sen P, Nayak R, Clark CA, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao
LV. Factor X binding to endothelial cell protein C receptor:comparison with
factor VIIa and activated protein C.Blood.2011;118(9):2635-6.
Yang Y, Groshong JS, Matta H, Gopalakrishnan R, Yi H, Chaudhary PM. Constitutive
NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to
dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma
cells. J Biol Chem. 2011 Aug 12;286(32):27988-97.
Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary PM. A20 is
induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory
protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative
feedback manner. J Biol Chem. 2011 Jun 17;286(24):21555-64.
Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT,
Pendurthi UR, Rao LV. Factor VIIa bound to endothelial cell protein C receptor
activates protease activated receptor-1 and mediates cell signaling and barrier
protection. Blood. 2011 Mar 17; 117(11):3199-208.
Gopalakrishnan R, Hedner U, Clark C, Pendurthi UR, Rao LV. rFVIIa
transported from the blood stream into tissues is functionally active. J Thromb
Haemost. 2010 Oct;8(10):2318-21.
Gopalakrishnan R, Hedner U, Ghosh S, Nayak RC, Allen TC, Pendurthi UR and
Rao LV. Bio-distribution of pharmacologically administered recombinant factor
VIIa (rFVIIa). J Thromb Haemost. 2010; 8(2):301-10.
Nayak RC, Sen P, Ghosh S, Gopalakrishnan R, Esmon CT, Pendurthi UR and Rao
LV. Endothelial cell protein C receptor cellular localization and trafficking:
potential functional implications. Blood. 2009; 114(9):1974-86.
Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Devaki T. Capsaicin
provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in
Swiss albino mice. Int Immunopharmacol. 2013 Oct;17(2):254-9.
Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Asokkumar S,
Naveenkumar C, Raghunandhakumar S, Devaki T. Capsaicin inhibits
benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm
Res. 2012 Nov;61(11):1169-75.
Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T. Modulatory
effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis
with reference to COX-2, MMP-2 and MMP-9. Eur J Pharmacol. 2010 Dec
Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T. Hesperidin
attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung
carcinogenesis in mice. Fundam Clin Pharmacol. 2011 Feb;25(1):91-8.
Last Updated: 2015/6/15