ABSTRACT The reference values of serum perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations were evaluated based on the human blood samples collected from Kashi, Xinjiang. And human serum samples of family members from Liaoning were evaluated for levels of PFOS and PFOA with the purpose to compare exposure pathways for family members. Among the 110 blood specimens from Kashi, the detection frequency of PFOS and PFOA was 93% and 6%, respectively. Reference values of serum PFOS, evaluated as the 90th percentiles of the concentrations, were determined to be 6.44 μg/L. Significant positive correlations were observed for serum levels of PFOS and PFOA among family members in Liaoning. Specially, stronger correlation between mother and offspring was observed than that between father and offspring. And stronger correlation of serum PFOS and PFOA levels was observed among fam- ily members in rural areas than those in big and small-medium cities. Difference in the association of serum PFOS and PFOA level among family members suggested that exposure in the outdoor and working environment of different oc- cupations should be evaluated. Present study provides reference values for exposure assessment in China and potential pathways of human exposure to PFOS and PFOA.
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W. Liu, G. Dong, Y. Luo, L. Liu, Z. Cao, X. Li and Y. Jin, "Estimation of Reference Values for PFOS and PFOA in Human Biomonitoring and Relevance of Exposure among Family Members in China," Journal of Environmental Protection, Vol. 3 No. 4, 2012, pp. 353-361. doi: 10.4236/jep.2012.34045.
 M., Houde, J. W. Martin, R. J. Letcher, K. R. Solomon and D. C. G. Muir, “Biological Monitoring of Polyfluoro- alkyl Substances: A Review,” Environmental Science & Technology, Vol. 40, No. 11, 2006, pp. 3463-3473.
 C. Lau, K. Anitole, C. Hodes, D. Lai, A. Pfahles-Hutchens and J. Seed, “Perfluoroalkyl Acids: A Review of Moni- toring and Toxicological Findings,” Toxicological Sci- ences, Vol. 99, No. 2, 2007, pp. 366-394.
 H. Fromme, S. A. Tittlemier, W. Volkel, M. Wilhelm and D. Twardella, “Perfluorinated Compounds—Exposure As- sessment for the General Population in Western Coun- tries,” International Journal of Hygiene and Environ- mental Health, Vol. 212, No. 3, 2009, pp. 239-270.
 M. Murakami, E. Imamura, H. Shinohara, K. Kiri, Y. Muramatsu, A. Harada and H. Takada, “Occurrence and Sources of Perfluorinated Surfactants in Rivers in Japan,” Environmental Science & Technology, Vol. 42, No. 17, 2008, pp. 6566-6572.doi:10.1021/es800353f
 L. Tao, J. Ma, T. Kunisue, E. L. Libelo, S. Tanabe and K. Kannan, “Perfluorinated Compounds in Human Breast Milk from Several Asian Countries, and in Infant For- mula and Dairy Milk from the United States,” Environ- mental Science & Technology, Vol. 42, No. 22, 2008, pp. 8597-8602. doi:10.1021/es801875v
 L. W. Y. Yeung, Y. Miyake, Y. Wang, S. Taniyasu, N. Yamashita and P. K. S. Lam, “Total Fluorine, Extractable Organic Fluorine, Perfluorooctane Sulfonate and other Related Fluorochemicals in Liver of Indo-Pacific Hump- back Dolphins (Sousa chinensis) and Finless Porpoises (Neophocaena phocaenoides) from South China,” Envi- ronmental Pollution, Vol. 157, No. 1, 2009, pp. 17-23.
 J. Holzer, O. Midasch, K. Rauchfuss, M. Kraft, R. Reu- pert, J. Angerer, P. Kleeschulte, N. Marschall and M. Wilhelm, “Biomonitoring of Perfluorinated Compounds in Children and Adults Exposed to Perfluorooctanoate- Contaminated Drinking Water,” Environmental Health Perspectives, Vol. 116, No. 5, 2008, pp. 651-657.
 M. Wilhelm, J. Holzer, L. Dobler, K. Rauchfuss, O. Mi- dasch, M. Kraft, J. Angerer and G. Wiesmuller, “Pre- liminary Observations on Perfluorinated Compounds in Plasma Samples (1977-2004) of Young German Adults from an Area with Perfluorooctanoate-Contaminated Drink- ing Water,” International Journal of Hygiene and Envi- ronmental Health, Vol. 212, No. 2, 2009, pp. 142-145.
 R. Vestergren and I. T. Cousins, “Tracking the Pathways of Human Exposure to Perfluorocarboxylates,” Environ- mental Science & Technology, Vol. 43, No. 15, 2009, pp. 5565-5575. doi:10.1021/es900228k
 K. Harada, N. Saito, K. Inoue, T. Yoshinaga, T. Wata- nabe, S. Sasaki, S. Kamiyama and A. Koizumi, “The In- fluence of Time, Sex and Geographic Factors on Levels of Perfluorooctane Sulfonate and Perfluorooctanoate in Human Serum over the Last 25 Years,” Journal of Occu- pational Health, Vol. 46, No. 2, 2004, pp. 141-147.
 Y. H. Jin, N. Saito, K. H. Harada, K. Inoue and A. Koi- zumi, “Historical Trends in Human Serum Levels of Per- fluorooctanoate and Perfluorooctane Sulfonate in Shen- yang, China,” Tohoku Journal of Experimental Medicine, Vol. 212, No. 1, 2007, pp. 63-70.
 B. H. Alexander, G. W. Olsen, J. M. Burris, J. H. Mandel and J. S. Mandel, “Mortality of Employees of a Per- fluorooctanesulphonyl Fluoride Manufacturing Facility,” Occupational and Environmental Medicine, Vol. 60, No. 10, 2003, pp. 722-729.
 B. J. Apelberg, F. R. Witter, J. B. Herbstman, A. M. Calafat, R. U. Halden, L. L. Needham and L. R. Goldman, “Cord serum Concentrations of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) in Relation to Weight and Size at Birth,” Environmental Health Per- spectives, Vol. 115, No. 11, 2007, pp. 1670-1676.
 C. Fei, J. K. Mclaughlin, R. E. Tarone and J. Olsen, “Per- fluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort,” Environmental Health Perspectives, Vol. 115, No. 11, 2007, pp. 1677-1682.
 N. Washino, Y. Saijo, S. Sasaki, S. Kato, S. Ban, K. Konishi, R. Ito, A. Nakata, Y. Iwasaki, K. Saito, H. Na- kazawa and R. Kishi, “Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth,” Environmental Health Perspect, Vol. 117, No. 4, 2009, pp. 660-667.
 Y. H. Jin, W. Liu, I. Sato, S. F. Nakayama, K. Sasaki, N. Saito and S. Tsuda, “PFOS and PFOA in Environmental and Tap Water in China,” Chemosphere, Vol. 77, No. 5, 2009, pp. 605-611.
 Y. H. Jin, G. H. Dong, W. Q. Shu, M. Ding, C. Zhai, L. Wang, X. Liu, N. Saito and K. Sasaki, “Comparison of Perfluorooctane Sulfonate and Perfluorooctane Acid in Serum of Non-Occupational Human from Shenyang and Chongqing Areas,” Journal of Hygiene Research, Vol. 35, No. 5, 2006, pp. 560-563.
 L. W. Y. Yeung, M. K. So, G. B. Jiang, S. Taniyasu, N. Yamashita, M. Y. Song, Y. N. Wu, J. G. Li, J. P. Giesy, K. S. Guruge and P. K. S. Lam, “Perfluorooctanesul- fonate and Related Fluorochemicals in Human Blood Samples from China,” Environmental Science & Tech- nology, Vol. 40, No. 3, 2006, pp. 715-720.
 K. J. Hansen, L. A. Clemen, M. E. Ellefson and H. O. Johnson, “Compound-Specific, Quantitative Characteriza- tion of Organic Fluorochemicals in Biological Matrices,” Environmental Science & Technology, Vol. 35, No. 4, 2001, pp. 766-770. doi:10.1021/es001489z
 W. Liu, X. Li, L. Xu, L. Liu, Y.H. Jin, I. Sata and S. Tsuda, “Influence of Gestation and Regular Bleeding on Blood Perfluorooctane Sulfonate Levels in Mice: Evalua- tion of Potential Factors Inducing Sex Difference in Blood Levels,” Journal of Toxicological Sciences, Vol. 35, No. 3, 2010, pp. 309-306. doi:10.2131/jts.35.309
 H. Fromme, C. Mosch, M. Morovitz, I. Alba-Alejandre, S. Boehmer, M. Kiranoglu, F. Faber, I. Hannibal, O. Genzel- Boroviczeny, B. Koletzko and W. Volkel, “Preand Post- natal Exposure to Perfluorinated Compounds (PFCs),” Environmental Science & Technology, Vol. 44, No. 18, 2010, pp. 7123-7129. doi:10.1021/es101184f
 K. Inoue, F. Okada, R. Ito, S. Kato, S. Sasaki, S. Nakajima, A. Uno, Y. Saijo, F. Sata, Y. Yoshimura, R. Kishi and H. Nakazawa, “Perfluorooctane Sulfonate (PFOS) and Related Perfluorinated Compounds in Human Ma- ternal and Cord Blood Samples: Assessment of PFOS Exposure in a Susceptible Population during Pregnancy.” Environmental Health Perspectives, Vol. 112, No. 11, 2004, pp. 1204-1207. doi:10.1289/ehp.6864
 L. Roosens, W. D’Hollander, L. Bervoets, H. Reynders, K. Van Campenhout, C. Cornelis, R. Van Den Heuvel, G. Koppen and A. Covaci, “Brominated Flame Retardants and Perfluorinated Chemicals, Two Groups of Persistent Contaminants in Belgian Human Blood and Milk,” Envi- ronmental Pollution, Vol. 158, No. 8, 2010, pp. 2546- 2552. doi:10.1016/j.envpol.2010.05.022
 A. K?rrman, I. Ericson, B. Van Bavel, P. O. Darnerud, M. Aune, A. Glynn, S. Lignell and G. Lindstr?m, “Exposure of Perfluorinated Chemicals through Lactation: Levels of Matched Human Milk and Serum and a Temporal Trend, 1996-2004, in Sweden,” Environmental Health Perspec- tives, Vol. 115, No. 2, 2007, pp. 226-230.